| Full name: enhancer of mRNA decapping 4 | Alias Symbol: RCD-8|Ge-1|HEDLS | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 23644 | HGNC ID: HGNC:17157 | Ensembl Gene: ENSG00000038358 | OMIM ID: 606030 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EDC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EDC4 | 23644 | 202496_at | 0.5048 | 0.1185 | |
| GSE20347 | EDC4 | 23644 | 202496_at | 0.4689 | 0.0000 | |
| GSE23400 | EDC4 | 23644 | 202496_at | 0.1301 | 0.0142 | |
| GSE26886 | EDC4 | 23644 | 202496_at | 0.6836 | 0.0000 | |
| GSE29001 | EDC4 | 23644 | 202496_at | 0.1609 | 0.1882 | |
| GSE38129 | EDC4 | 23644 | 202496_at | 0.4133 | 0.0002 | |
| GSE45670 | EDC4 | 23644 | 202496_at | 0.2432 | 0.0172 | |
| GSE53622 | EDC4 | 23644 | 22513 | 0.3479 | 0.0000 | |
| GSE53624 | EDC4 | 23644 | 22513 | 0.3938 | 0.0000 | |
| GSE63941 | EDC4 | 23644 | 202496_at | 0.4464 | 0.1380 | |
| GSE77861 | EDC4 | 23644 | 202496_at | 0.5103 | 0.0030 | |
| GSE97050 | EDC4 | 23644 | A_24_P399009 | 0.1271 | 0.5183 | |
| SRP007169 | EDC4 | 23644 | RNAseq | 0.1838 | 0.6106 | |
| SRP008496 | EDC4 | 23644 | RNAseq | -0.0754 | 0.7472 | |
| SRP064894 | EDC4 | 23644 | RNAseq | 0.1185 | 0.4784 | |
| SRP133303 | EDC4 | 23644 | RNAseq | 0.3039 | 0.0543 | |
| SRP159526 | EDC4 | 23644 | RNAseq | 0.6184 | 0.0718 | |
| SRP193095 | EDC4 | 23644 | RNAseq | 0.5386 | 0.0000 | |
| SRP219564 | EDC4 | 23644 | RNAseq | -0.0087 | 0.9675 | |
| TCGA | EDC4 | 23644 | RNAseq | 0.0146 | 0.7442 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EDC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EDC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EDC4 | 23644 | 9 | 2 | 19 | |
| GSE20123 | EDC4 | 23644 | 9 | 2 | 19 | |
| GSE43470 | EDC4 | 23644 | 1 | 9 | 33 | |
| GSE46452 | EDC4 | 23644 | 38 | 1 | 20 | |
| GSE47630 | EDC4 | 23644 | 11 | 8 | 21 | |
| GSE54993 | EDC4 | 23644 | 2 | 4 | 64 | |
| GSE54994 | EDC4 | 23644 | 8 | 10 | 35 | |
| GSE60625 | EDC4 | 23644 | 4 | 0 | 7 | |
| GSE74703 | EDC4 | 23644 | 1 | 6 | 29 | |
| GSE74704 | EDC4 | 23644 | 5 | 1 | 14 | |
| TCGA | EDC4 | 23644 | 30 | 12 | 54 |
Total number of gains: 118; Total number of losses: 55; Total Number of normals: 315.
Somatic mutations of EDC4:
Generating mutation plots.
Highly correlated genes for EDC4:
Showing top 20/1350 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EDC4 | SFR1 | 0.823039 | 3 | 0 | 3 |
| EDC4 | NIPSNAP1 | 0.768152 | 5 | 0 | 5 |
| EDC4 | ZNF778 | 0.739879 | 3 | 0 | 3 |
| EDC4 | DYNC1LI2 | 0.734898 | 3 | 0 | 3 |
| EDC4 | SLC7A6OS | 0.723479 | 5 | 0 | 4 |
| EDC4 | POLR2A | 0.722732 | 3 | 0 | 3 |
| EDC4 | ARFRP1 | 0.719703 | 3 | 0 | 3 |
| EDC4 | C7orf50 | 0.716361 | 4 | 0 | 4 |
| EDC4 | ZNF670 | 0.715797 | 4 | 0 | 4 |
| EDC4 | A1BG | 0.713076 | 3 | 0 | 3 |
| EDC4 | KLHL13 | 0.712712 | 4 | 0 | 4 |
| EDC4 | C15orf61 | 0.709904 | 3 | 0 | 3 |
| EDC4 | NOTCH3 | 0.699393 | 3 | 0 | 3 |
| EDC4 | SLC7A6 | 0.697361 | 8 | 0 | 8 |
| EDC4 | POLDIP2 | 0.694344 | 3 | 0 | 3 |
| EDC4 | MEX3C | 0.692864 | 3 | 0 | 3 |
| EDC4 | C1orf226 | 0.687629 | 3 | 0 | 3 |
| EDC4 | EFTUD2 | 0.687155 | 8 | 0 | 6 |
| EDC4 | LITAF | 0.686268 | 5 | 0 | 5 |
| EDC4 | PSMD7 | 0.68617 | 4 | 0 | 4 |
For details and further investigation, click here
