| Full name: notch receptor 3 | Alias Symbol: CASIL | ||
| Type: protein-coding gene | Cytoband: 19p13.12 | ||
| Entrez ID: 4854 | HGNC ID: HGNC:7883 | Ensembl Gene: ENSG00000074181 | OMIM ID: 600276 |
| Drug and gene relationship at DGIdb | |||
NOTCH3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway | |
| hsa04919 | Thyroid hormone signaling pathway |
Expression of NOTCH3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NOTCH3 | 4854 | 203238_s_at | 0.6026 | 0.2310 | |
| GSE20347 | NOTCH3 | 4854 | 203238_s_at | -0.2415 | 0.3192 | |
| GSE23400 | NOTCH3 | 4854 | 203238_s_at | 0.2930 | 0.0123 | |
| GSE26886 | NOTCH3 | 4854 | 203238_s_at | -0.0033 | 0.9891 | |
| GSE29001 | NOTCH3 | 4854 | 203238_s_at | 0.2127 | 0.5757 | |
| GSE38129 | NOTCH3 | 4854 | 203238_s_at | 0.0182 | 0.9482 | |
| GSE45670 | NOTCH3 | 4854 | 203238_s_at | 0.0704 | 0.7834 | |
| GSE53622 | NOTCH3 | 4854 | 78359 | 0.0864 | 0.4763 | |
| GSE53624 | NOTCH3 | 4854 | 78359 | 0.2603 | 0.0003 | |
| GSE63941 | NOTCH3 | 4854 | 203238_s_at | 2.1652 | 0.0016 | |
| GSE77861 | NOTCH3 | 4854 | 203238_s_at | 0.5912 | 0.1839 | |
| GSE97050 | NOTCH3 | 4854 | A_33_P3313055 | 0.3877 | 0.2172 | |
| SRP007169 | NOTCH3 | 4854 | RNAseq | 0.1326 | 0.7109 | |
| SRP008496 | NOTCH3 | 4854 | RNAseq | 0.1751 | 0.5145 | |
| SRP064894 | NOTCH3 | 4854 | RNAseq | 0.2814 | 0.2152 | |
| SRP133303 | NOTCH3 | 4854 | RNAseq | -0.0523 | 0.7566 | |
| SRP159526 | NOTCH3 | 4854 | RNAseq | 0.2349 | 0.5925 | |
| SRP193095 | NOTCH3 | 4854 | RNAseq | 0.3294 | 0.2327 | |
| SRP219564 | NOTCH3 | 4854 | RNAseq | -0.0625 | 0.8879 | |
| TCGA | NOTCH3 | 4854 | RNAseq | 0.4468 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NOTCH3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NOTCH3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NOTCH3 | 4854 | 4 | 2 | 24 | |
| GSE20123 | NOTCH3 | 4854 | 3 | 1 | 26 | |
| GSE43470 | NOTCH3 | 4854 | 2 | 6 | 35 | |
| GSE46452 | NOTCH3 | 4854 | 47 | 1 | 11 | |
| GSE47630 | NOTCH3 | 4854 | 4 | 7 | 29 | |
| GSE54993 | NOTCH3 | 4854 | 15 | 4 | 51 | |
| GSE54994 | NOTCH3 | 4854 | 6 | 13 | 34 | |
| GSE60625 | NOTCH3 | 4854 | 9 | 0 | 2 | |
| GSE74703 | NOTCH3 | 4854 | 2 | 4 | 30 | |
| GSE74704 | NOTCH3 | 4854 | 0 | 1 | 19 | |
| TCGA | NOTCH3 | 4854 | 21 | 10 | 65 |
Total number of gains: 113; Total number of losses: 49; Total Number of normals: 326.
Somatic mutations of NOTCH3:
Generating mutation plots.
Highly correlated genes for NOTCH3:
Showing top 20/655 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NOTCH3 | BCL7C | 0.821882 | 3 | 0 | 3 |
| NOTCH3 | NACC1 | 0.790225 | 3 | 0 | 3 |
| NOTCH3 | EEFSEC | 0.78369 | 3 | 0 | 3 |
| NOTCH3 | BLM | 0.766132 | 3 | 0 | 3 |
| NOTCH3 | CDK18 | 0.761077 | 3 | 0 | 3 |
| NOTCH3 | RGS19 | 0.757827 | 3 | 0 | 3 |
| NOTCH3 | DCXR | 0.755876 | 3 | 0 | 3 |
| NOTCH3 | PPP1R9B | 0.753586 | 4 | 0 | 3 |
| NOTCH3 | MCM6 | 0.749361 | 3 | 0 | 3 |
| NOTCH3 | GANAB | 0.746735 | 4 | 0 | 4 |
| NOTCH3 | RTKN | 0.746249 | 4 | 0 | 4 |
| NOTCH3 | SUGP1 | 0.746025 | 3 | 0 | 3 |
| NOTCH3 | GORAB | 0.74579 | 3 | 0 | 3 |
| NOTCH3 | ZNF830 | 0.745469 | 3 | 0 | 3 |
| NOTCH3 | CDCA7 | 0.745186 | 3 | 0 | 3 |
| NOTCH3 | NIT1 | 0.743691 | 3 | 0 | 3 |
| NOTCH3 | ANP32B | 0.739853 | 3 | 0 | 3 |
| NOTCH3 | MRPL38 | 0.736261 | 3 | 0 | 3 |
| NOTCH3 | HELLS | 0.732748 | 3 | 0 | 3 |
| NOTCH3 | OCIAD2 | 0.732178 | 3 | 0 | 3 |
For details and further investigation, click here
