| Full name: RNA polymerase II subunit A | Alias Symbol: POLRA|RPB1 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 5430 | HGNC ID: HGNC:9187 | Ensembl Gene: ENSG00000181222 | OMIM ID: 180660 |
| Drug and gene relationship at DGIdb | |||
Expression of POLR2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLR2A | 5430 | 202725_at | 0.1531 | 0.7140 | |
| GSE20347 | POLR2A | 5430 | 202725_at | 0.0710 | 0.5297 | |
| GSE23400 | POLR2A | 5430 | 202725_at | 0.2122 | 0.0035 | |
| GSE26886 | POLR2A | 5430 | 202725_at | 0.5046 | 0.0002 | |
| GSE29001 | POLR2A | 5430 | 202725_at | -0.0035 | 0.9907 | |
| GSE38129 | POLR2A | 5430 | 202725_at | 0.1870 | 0.0534 | |
| GSE45670 | POLR2A | 5430 | 202725_at | 0.1173 | 0.4178 | |
| GSE53622 | POLR2A | 5430 | 134916 | -0.0192 | 0.8720 | |
| GSE53624 | POLR2A | 5430 | 134916 | -0.0606 | 0.3371 | |
| GSE63941 | POLR2A | 5430 | 202725_at | 0.1456 | 0.6877 | |
| GSE77861 | POLR2A | 5430 | 202725_at | 0.3972 | 0.0724 | |
| GSE97050 | POLR2A | 5430 | A_33_P3218138 | -0.0904 | 0.8057 | |
| SRP007169 | POLR2A | 5430 | RNAseq | 0.9420 | 0.0105 | |
| SRP008496 | POLR2A | 5430 | RNAseq | 0.7202 | 0.0082 | |
| SRP064894 | POLR2A | 5430 | RNAseq | -0.2247 | 0.3593 | |
| SRP133303 | POLR2A | 5430 | RNAseq | -0.1784 | 0.2979 | |
| SRP159526 | POLR2A | 5430 | RNAseq | -0.1286 | 0.5305 | |
| SRP193095 | POLR2A | 5430 | RNAseq | -0.1538 | 0.1735 | |
| SRP219564 | POLR2A | 5430 | RNAseq | -0.0195 | 0.9577 | |
| TCGA | POLR2A | 5430 | RNAseq | 0.0725 | 0.0922 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POLR2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLR2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLR2A | 5430 | 4 | 2 | 24 | |
| GSE20123 | POLR2A | 5430 | 4 | 3 | 23 | |
| GSE43470 | POLR2A | 5430 | 1 | 4 | 38 | |
| GSE46452 | POLR2A | 5430 | 34 | 1 | 24 | |
| GSE47630 | POLR2A | 5430 | 7 | 1 | 32 | |
| GSE54993 | POLR2A | 5430 | 4 | 3 | 63 | |
| GSE54994 | POLR2A | 5430 | 5 | 8 | 40 | |
| GSE60625 | POLR2A | 5430 | 4 | 0 | 7 | |
| GSE74703 | POLR2A | 5430 | 1 | 2 | 33 | |
| GSE74704 | POLR2A | 5430 | 2 | 1 | 17 | |
| TCGA | POLR2A | 5430 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of POLR2A:
Generating mutation plots.
Highly correlated genes for POLR2A:
Showing top 20/595 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLR2A | NLK | 0.854659 | 3 | 0 | 3 |
| POLR2A | TP53I13 | 0.807529 | 3 | 0 | 3 |
| POLR2A | AKT2 | 0.803895 | 3 | 0 | 3 |
| POLR2A | ZNF76 | 0.788224 | 3 | 0 | 3 |
| POLR2A | ALKBH6 | 0.778671 | 3 | 0 | 3 |
| POLR2A | RPL7L1 | 0.772749 | 3 | 0 | 3 |
| POLR2A | NCDN | 0.765032 | 3 | 0 | 3 |
| POLR2A | GPR160 | 0.760607 | 3 | 0 | 3 |
| POLR2A | FARS2 | 0.756442 | 3 | 0 | 3 |
| POLR2A | CLEC11A | 0.756356 | 3 | 0 | 3 |
| POLR2A | SMARCD2 | 0.753334 | 4 | 0 | 4 |
| POLR2A | MXD3 | 0.751295 | 4 | 0 | 4 |
| POLR2A | LIMD2 | 0.749914 | 3 | 0 | 3 |
| POLR2A | PEX14 | 0.748002 | 3 | 0 | 3 |
| POLR2A | FAM167B | 0.746524 | 3 | 0 | 3 |
| POLR2A | HEATR6 | 0.743343 | 3 | 0 | 3 |
| POLR2A | C20orf27 | 0.741818 | 3 | 0 | 3 |
| POLR2A | MATN4 | 0.736734 | 3 | 0 | 3 |
| POLR2A | MYH10 | 0.73664 | 3 | 0 | 3 |
| POLR2A | CKAP5 | 0.7316 | 3 | 0 | 3 |
For details and further investigation, click here
