| Full name: exosome component 8 | Alias Symbol: OIP2|RRP43|bA421P11.3|Rrp43p|EAP2|p9|CIP3 | ||
| Type: protein-coding gene | Cytoband: 13q13.3 | ||
| Entrez ID: 11340 | HGNC ID: HGNC:17035 | Ensembl Gene: ENSG00000120699 | OMIM ID: 606019 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXOSC8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOSC8 | 11340 | 215136_s_at | 0.1896 | 0.6532 | |
| GSE20347 | EXOSC8 | 11340 | 215136_s_at | 0.2377 | 0.1309 | |
| GSE23400 | EXOSC8 | 11340 | 215136_s_at | 0.4542 | 0.0000 | |
| GSE26886 | EXOSC8 | 11340 | 215136_s_at | 0.7255 | 0.0003 | |
| GSE29001 | EXOSC8 | 11340 | 215136_s_at | 0.2023 | 0.7062 | |
| GSE38129 | EXOSC8 | 11340 | 215136_s_at | 0.2851 | 0.0165 | |
| GSE45670 | EXOSC8 | 11340 | 215136_s_at | 0.0643 | 0.6880 | |
| GSE53622 | EXOSC8 | 11340 | 81685 | 0.3730 | 0.0000 | |
| GSE53624 | EXOSC8 | 11340 | 81685 | 0.4906 | 0.0000 | |
| GSE63941 | EXOSC8 | 11340 | 215136_s_at | 1.2626 | 0.0032 | |
| GSE77861 | EXOSC8 | 11340 | 215136_s_at | 0.1756 | 0.6925 | |
| GSE97050 | EXOSC8 | 11340 | A_24_P241276 | 0.1311 | 0.5827 | |
| SRP007169 | EXOSC8 | 11340 | RNAseq | 0.0605 | 0.8833 | |
| SRP008496 | EXOSC8 | 11340 | RNAseq | 0.2919 | 0.4497 | |
| SRP064894 | EXOSC8 | 11340 | RNAseq | 0.3674 | 0.0179 | |
| SRP133303 | EXOSC8 | 11340 | RNAseq | 0.0188 | 0.9317 | |
| SRP159526 | EXOSC8 | 11340 | RNAseq | -0.4254 | 0.0343 | |
| SRP193095 | EXOSC8 | 11340 | RNAseq | -0.1908 | 0.1035 | |
| SRP219564 | EXOSC8 | 11340 | RNAseq | -0.2419 | 0.4642 | |
| TCGA | EXOSC8 | 11340 | RNAseq | 0.1789 | 0.0073 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by EXOSC8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOSC8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOSC8 | 11340 | 0 | 16 | 14 | |
| GSE20123 | EXOSC8 | 11340 | 0 | 15 | 15 | |
| GSE43470 | EXOSC8 | 11340 | 2 | 14 | 27 | |
| GSE46452 | EXOSC8 | 11340 | 0 | 33 | 26 | |
| GSE47630 | EXOSC8 | 11340 | 2 | 27 | 11 | |
| GSE54993 | EXOSC8 | 11340 | 12 | 2 | 56 | |
| GSE54994 | EXOSC8 | 11340 | 1 | 17 | 35 | |
| GSE60625 | EXOSC8 | 11340 | 0 | 3 | 8 | |
| GSE74703 | EXOSC8 | 11340 | 2 | 11 | 23 | |
| GSE74704 | EXOSC8 | 11340 | 0 | 12 | 8 | |
| TCGA | EXOSC8 | 11340 | 7 | 40 | 49 |
Total number of gains: 26; Total number of losses: 190; Total Number of normals: 272.
Somatic mutations of EXOSC8:
Generating mutation plots.
Highly correlated genes for EXOSC8:
Showing top 20/880 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOSC8 | DHX40 | 0.782651 | 3 | 0 | 3 |
| EXOSC8 | ALKBH6 | 0.777588 | 3 | 0 | 3 |
| EXOSC8 | CWF19L2 | 0.772328 | 3 | 0 | 3 |
| EXOSC8 | C2orf69 | 0.757344 | 3 | 0 | 3 |
| EXOSC8 | CEP120 | 0.752641 | 3 | 0 | 3 |
| EXOSC8 | RIMKLB | 0.751248 | 3 | 0 | 3 |
| EXOSC8 | ANAPC4 | 0.738115 | 4 | 0 | 4 |
| EXOSC8 | TMEM65 | 0.729972 | 3 | 0 | 3 |
| EXOSC8 | FCF1 | 0.728411 | 4 | 0 | 3 |
| EXOSC8 | PET117 | 0.727912 | 4 | 0 | 3 |
| EXOSC8 | GOSR1 | 0.727814 | 3 | 0 | 3 |
| EXOSC8 | RAD23A | 0.726691 | 4 | 0 | 3 |
| EXOSC8 | EIF1AX | 0.717948 | 3 | 0 | 3 |
| EXOSC8 | CISD2 | 0.713997 | 3 | 0 | 3 |
| EXOSC8 | TTYH2 | 0.710177 | 3 | 0 | 3 |
| EXOSC8 | DUSP23 | 0.708826 | 3 | 0 | 3 |
| EXOSC8 | HNRNPUL1 | 0.706163 | 3 | 0 | 3 |
| EXOSC8 | REPS1 | 0.705052 | 3 | 0 | 3 |
| EXOSC8 | RAVER1 | 0.704134 | 3 | 0 | 3 |
| EXOSC8 | GNL3L | 0.703307 | 3 | 0 | 3 |
For details and further investigation, click here
