CEP120

 

Full name: centrosomal protein 120 Alias Symbol: FLJ36090
Type: protein-coding gene Cytoband: 5q23.2
Entrez ID: 153241 HGNC ID: HGNC:26690 Ensembl Gene: ENSG00000168944 OMIM ID: 613446
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CEP120:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CEP120 153241 226449_at 0.0463 0.9245
GSE26886 CEP120 153241 226449_at 0.9137 0.0001
GSE45670 CEP120 153241 226449_at -0.1621 0.3437
GSE53622 CEP120 153241 137398 0.0214 0.8446
GSE53624 CEP120 153241 137398 -0.0707 0.5692
GSE63941 CEP120 153241 226449_at -0.2586 0.6217
GSE77861 CEP120 153241 226449_at 0.0983 0.5127
GSE97050 CEP120 153241 A_24_P226210 0.2588 0.3602
SRP007169 CEP120 153241 RNAseq 1.1611 0.0302
SRP008496 CEP120 153241 RNAseq 1.9153 0.0000
SRP064894 CEP120 153241 RNAseq 0.1942 0.3544
SRP133303 CEP120 153241 RNAseq 0.3597 0.0045
SRP159526 CEP120 153241 RNAseq 0.0949 0.8010
SRP193095 CEP120 153241 RNAseq -0.1093 0.2511
SRP219564 CEP120 153241 RNAseq 0.2366 0.4796
TCGA CEP120 153241 RNAseq -0.1256 0.0302

Upregulated datasets: 2; Downregulated datasets: 0.  


 

Survival by CEP120 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of CEP120:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CEP120 153241 1 13 16
GSE20123 CEP120 153241 1 13 16
GSE43470 CEP120 153241 3 8 32
GSE46452 CEP120 153241 0 27 32
GSE47630 CEP120 153241 0 21 19
GSE54993 CEP120 153241 9 1 60
GSE54994 CEP120 153241 2 14 37
GSE60625 CEP120 153241 0 0 11
GSE74703 CEP120 153241 2 6 28
GSE74704 CEP120 153241 1 7 12
TCGA CEP120 153241 2 40 54

Total number of gains: 21; Total number of losses: 150; Total Number of normals: 317.  


 

Somatic mutations of CEP120:

 

Generating mutation plots.

 

Highly correlated genes for CEP120:

 

Showing top 20/606 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CEP120COL4A10.782907303
CEP120ITGAV0.776239303
CEP120IMMP1L0.760639303
CEP120SLC6A60.759397303
CEP120GSTO10.757292303
CEP120EXOSC80.752641303
CEP120ARFGAP30.75155303
CEP120ARHGAP240.750356505
CEP120PXDN0.748145303
CEP120DUT0.741275303
CEP120METTL230.74089303
CEP120APH1B0.738829404
CEP120COPB10.737751303
CEP120GMCL10.737596303
CEP120CKAP50.737534303
CEP120PPT10.737447303
CEP120SFT2D30.735318303
CEP120ELF40.735264303
CEP120BIRC60.734138303
CEP120SH3RF30.73252303

For details and further investigation, click here