| Full name: exostosin glycosyltransferase 2 | Alias Symbol: SOTV | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 2132 | HGNC ID: HGNC:3513 | Ensembl Gene: ENSG00000151348 | OMIM ID: 608210 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXT2 | 2132 | 202012_s_at | 0.5054 | 0.2590 | |
| GSE20347 | EXT2 | 2132 | 202012_s_at | 0.2889 | 0.1232 | |
| GSE23400 | EXT2 | 2132 | 202012_s_at | 0.6133 | 0.0000 | |
| GSE26886 | EXT2 | 2132 | 202012_s_at | 0.8195 | 0.0018 | |
| GSE29001 | EXT2 | 2132 | 202012_s_at | 0.2899 | 0.2079 | |
| GSE38129 | EXT2 | 2132 | 202012_s_at | 0.3247 | 0.0358 | |
| GSE45670 | EXT2 | 2132 | 202012_s_at | 0.4169 | 0.1286 | |
| GSE53622 | EXT2 | 2132 | 31775 | 0.4831 | 0.0000 | |
| GSE53624 | EXT2 | 2132 | 31775 | 0.6237 | 0.0000 | |
| GSE63941 | EXT2 | 2132 | 202012_s_at | -1.3317 | 0.0238 | |
| GSE77861 | EXT2 | 2132 | 202012_s_at | 0.5223 | 0.1918 | |
| GSE97050 | EXT2 | 2132 | A_23_P13183 | 0.2080 | 0.3948 | |
| SRP007169 | EXT2 | 2132 | RNAseq | 0.1831 | 0.6179 | |
| SRP008496 | EXT2 | 2132 | RNAseq | 0.8713 | 0.0018 | |
| SRP064894 | EXT2 | 2132 | RNAseq | 0.8240 | 0.0000 | |
| SRP133303 | EXT2 | 2132 | RNAseq | 1.0065 | 0.0000 | |
| SRP159526 | EXT2 | 2132 | RNAseq | 0.6543 | 0.0236 | |
| SRP193095 | EXT2 | 2132 | RNAseq | 0.6524 | 0.0001 | |
| SRP219564 | EXT2 | 2132 | RNAseq | 0.6812 | 0.0730 | |
| TCGA | EXT2 | 2132 | RNAseq | 0.0776 | 0.1232 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by EXT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXT2 | 2132 | 2 | 8 | 20 | |
| GSE20123 | EXT2 | 2132 | 2 | 7 | 21 | |
| GSE43470 | EXT2 | 2132 | 3 | 4 | 36 | |
| GSE46452 | EXT2 | 2132 | 8 | 5 | 46 | |
| GSE47630 | EXT2 | 2132 | 3 | 9 | 28 | |
| GSE54993 | EXT2 | 2132 | 3 | 0 | 67 | |
| GSE54994 | EXT2 | 2132 | 3 | 9 | 41 | |
| GSE60625 | EXT2 | 2132 | 0 | 0 | 11 | |
| GSE74703 | EXT2 | 2132 | 2 | 2 | 32 | |
| GSE74704 | EXT2 | 2132 | 2 | 5 | 13 | |
| TCGA | EXT2 | 2132 | 15 | 20 | 61 |
Total number of gains: 43; Total number of losses: 69; Total Number of normals: 376.
Somatic mutations of EXT2:
Generating mutation plots.
Highly correlated genes for EXT2:
Showing top 20/1159 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXT2 | CHML | 0.77306 | 3 | 0 | 3 |
| EXT2 | LRRC58 | 0.749874 | 3 | 0 | 3 |
| EXT2 | RAB34 | 0.727888 | 3 | 0 | 3 |
| EXT2 | HAUS1 | 0.727258 | 4 | 0 | 4 |
| EXT2 | SESN3 | 0.726662 | 4 | 0 | 4 |
| EXT2 | ADCY3 | 0.723288 | 4 | 0 | 4 |
| EXT2 | CD164 | 0.718631 | 3 | 0 | 3 |
| EXT2 | DDX20 | 0.713393 | 3 | 0 | 3 |
| EXT2 | HPS3 | 0.710664 | 3 | 0 | 3 |
| EXT2 | CCDC127 | 0.708668 | 3 | 0 | 3 |
| EXT2 | SLC46A1 | 0.701376 | 3 | 0 | 3 |
| EXT2 | MRPL55 | 0.70117 | 3 | 0 | 3 |
| EXT2 | STOML1 | 0.700753 | 4 | 0 | 4 |
| EXT2 | SPSB2 | 0.700614 | 4 | 0 | 4 |
| EXT2 | NEDD8 | 0.694437 | 5 | 0 | 4 |
| EXT2 | ZNF764 | 0.691305 | 3 | 0 | 3 |
| EXT2 | NF1 | 0.69099 | 3 | 0 | 3 |
| EXT2 | SDAD1 | 0.690448 | 4 | 0 | 4 |
| EXT2 | NUTF2 | 0.690047 | 8 | 0 | 8 |
| EXT2 | ELP2 | 0.686916 | 3 | 0 | 3 |
For details and further investigation, click here
