| Full name: splA/ryanodine receptor domain and SOCS box containing 2 | Alias Symbol: GRCC9|SSB-2 | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 84727 | HGNC ID: HGNC:29522 | Ensembl Gene: ENSG00000111671 | OMIM ID: 611658 |
| Drug and gene relationship at DGIdb | |||
Expression of SPSB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPSB2 | 84727 | 223580_at | 0.3045 | 0.2970 | |
| GSE26886 | SPSB2 | 84727 | 223580_at | 1.2785 | 0.0001 | |
| GSE45670 | SPSB2 | 84727 | 223580_at | 0.4554 | 0.0959 | |
| GSE53622 | SPSB2 | 84727 | 104841 | 0.2852 | 0.0238 | |
| GSE53624 | SPSB2 | 84727 | 104841 | 0.5822 | 0.0000 | |
| GSE63941 | SPSB2 | 84727 | 223580_at | -0.2770 | 0.5856 | |
| GSE77861 | SPSB2 | 84727 | 223580_at | 0.4245 | 0.0715 | |
| GSE97050 | SPSB2 | 84727 | A_33_P3218188 | 0.2561 | 0.2261 | |
| SRP007169 | SPSB2 | 84727 | RNAseq | 0.1119 | 0.8193 | |
| SRP008496 | SPSB2 | 84727 | RNAseq | 1.2773 | 0.0038 | |
| SRP064894 | SPSB2 | 84727 | RNAseq | 0.5858 | 0.0303 | |
| SRP133303 | SPSB2 | 84727 | RNAseq | 0.5523 | 0.0088 | |
| SRP159526 | SPSB2 | 84727 | RNAseq | 0.4304 | 0.2871 | |
| SRP193095 | SPSB2 | 84727 | RNAseq | 0.2313 | 0.0585 | |
| SRP219564 | SPSB2 | 84727 | RNAseq | 0.7558 | 0.1796 | |
| TCGA | SPSB2 | 84727 | RNAseq | 0.2650 | 0.0029 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SPSB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPSB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPSB2 | 84727 | 9 | 3 | 18 | |
| GSE20123 | SPSB2 | 84727 | 9 | 3 | 18 | |
| GSE43470 | SPSB2 | 84727 | 8 | 3 | 32 | |
| GSE46452 | SPSB2 | 84727 | 10 | 1 | 48 | |
| GSE47630 | SPSB2 | 84727 | 12 | 2 | 26 | |
| GSE54993 | SPSB2 | 84727 | 1 | 10 | 59 | |
| GSE54994 | SPSB2 | 84727 | 10 | 2 | 41 | |
| GSE60625 | SPSB2 | 84727 | 0 | 1 | 10 | |
| GSE74703 | SPSB2 | 84727 | 7 | 2 | 27 | |
| GSE74704 | SPSB2 | 84727 | 5 | 3 | 12 | |
| TCGA | SPSB2 | 84727 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 36; Total Number of normals: 341.
Somatic mutations of SPSB2:
Generating mutation plots.
Highly correlated genes for SPSB2:
Showing top 20/1198 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPSB2 | EHMT2 | 0.825065 | 3 | 0 | 3 |
| SPSB2 | SULT1A1 | 0.815927 | 3 | 0 | 3 |
| SPSB2 | UTP20 | 0.815468 | 3 | 0 | 3 |
| SPSB2 | ABCF1 | 0.794553 | 3 | 0 | 3 |
| SPSB2 | ATAD5 | 0.791257 | 3 | 0 | 3 |
| SPSB2 | FLYWCH2 | 0.787318 | 3 | 0 | 3 |
| SPSB2 | KCTD15 | 0.762692 | 3 | 0 | 3 |
| SPSB2 | KDM1B | 0.762035 | 3 | 0 | 3 |
| SPSB2 | ZNF121 | 0.759693 | 3 | 0 | 3 |
| SPSB2 | NAP1L4 | 0.75461 | 3 | 0 | 3 |
| SPSB2 | CHAF1B | 0.75324 | 3 | 0 | 3 |
| SPSB2 | LRP5L | 0.75271 | 3 | 0 | 3 |
| SPSB2 | ARHGEF19 | 0.749158 | 3 | 0 | 3 |
| SPSB2 | FADD | 0.748287 | 3 | 0 | 3 |
| SPSB2 | THEM4 | 0.746897 | 3 | 0 | 3 |
| SPSB2 | ARHGAP19 | 0.746706 | 3 | 0 | 3 |
| SPSB2 | CHML | 0.745857 | 4 | 0 | 4 |
| SPSB2 | ZBTB44 | 0.745467 | 3 | 0 | 3 |
| SPSB2 | PATZ1 | 0.745301 | 3 | 0 | 3 |
| SPSB2 | ACBD6 | 0.744446 | 4 | 0 | 4 |
For details and further investigation, click here
