| Full name: sestrin 3 | Alias Symbol: SEST3|MGC29667 | ||
| Type: protein-coding gene | Cytoband: 11q21 | ||
| Entrez ID: 143686 | HGNC ID: HGNC:23060 | Ensembl Gene: ENSG00000149212 | OMIM ID: 607768 |
| Drug and gene relationship at DGIdb | |||
SESN3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway | |
| hsa04211 | Longevity regulating pathway - mammal |
Expression of SESN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SESN3 | 143686 | 225123_at | 0.2338 | 0.6293 | |
| GSE26886 | SESN3 | 143686 | 225123_at | 0.8651 | 0.0066 | |
| GSE45670 | SESN3 | 143686 | 225123_at | 0.5695 | 0.0750 | |
| GSE53622 | SESN3 | 143686 | 59102 | 0.3896 | 0.0007 | |
| GSE53624 | SESN3 | 143686 | 59102 | 0.4321 | 0.0000 | |
| GSE63941 | SESN3 | 143686 | 225123_at | -2.4969 | 0.0753 | |
| GSE77861 | SESN3 | 143686 | 225123_at | 0.9650 | 0.0316 | |
| GSE97050 | SESN3 | 143686 | A_23_P361448 | 0.1502 | 0.5725 | |
| SRP007169 | SESN3 | 143686 | RNAseq | 2.1032 | 0.0002 | |
| SRP008496 | SESN3 | 143686 | RNAseq | 2.0832 | 0.0000 | |
| SRP064894 | SESN3 | 143686 | RNAseq | 0.6583 | 0.0575 | |
| SRP133303 | SESN3 | 143686 | RNAseq | 0.4189 | 0.0905 | |
| SRP159526 | SESN3 | 143686 | RNAseq | 0.9186 | 0.1711 | |
| SRP193095 | SESN3 | 143686 | RNAseq | 0.3891 | 0.0712 | |
| SRP219564 | SESN3 | 143686 | RNAseq | 0.1704 | 0.7808 | |
| TCGA | SESN3 | 143686 | RNAseq | 0.4366 | 0.0046 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SESN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SESN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SESN3 | 143686 | 3 | 8 | 19 | |
| GSE20123 | SESN3 | 143686 | 3 | 8 | 19 | |
| GSE43470 | SESN3 | 143686 | 2 | 5 | 36 | |
| GSE46452 | SESN3 | 143686 | 5 | 24 | 30 | |
| GSE47630 | SESN3 | 143686 | 2 | 19 | 19 | |
| GSE54993 | SESN3 | 143686 | 8 | 2 | 60 | |
| GSE54994 | SESN3 | 143686 | 6 | 18 | 29 | |
| GSE60625 | SESN3 | 143686 | 0 | 3 | 8 | |
| GSE74703 | SESN3 | 143686 | 1 | 4 | 31 | |
| GSE74704 | SESN3 | 143686 | 3 | 4 | 13 | |
| TCGA | SESN3 | 143686 | 11 | 43 | 42 |
Total number of gains: 44; Total number of losses: 138; Total Number of normals: 306.
Somatic mutations of SESN3:
Generating mutation plots.
Highly correlated genes for SESN3:
Showing top 20/392 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SESN3 | B4GALNT3 | 0.76711 | 3 | 0 | 3 |
| SESN3 | JTB | 0.752461 | 3 | 0 | 3 |
| SESN3 | MAPKAPK5 | 0.752264 | 3 | 0 | 3 |
| SESN3 | FAM169A | 0.750195 | 3 | 0 | 3 |
| SESN3 | MEX3C | 0.747428 | 3 | 0 | 3 |
| SESN3 | UXS1 | 0.744291 | 3 | 0 | 3 |
| SESN3 | MAGOHB | 0.736696 | 3 | 0 | 3 |
| SESN3 | EXT2 | 0.726662 | 4 | 0 | 4 |
| SESN3 | BLMH | 0.723314 | 3 | 0 | 3 |
| SESN3 | GLO1 | 0.721936 | 3 | 0 | 3 |
| SESN3 | ORC5 | 0.721327 | 3 | 0 | 3 |
| SESN3 | KPNA2 | 0.718747 | 3 | 0 | 3 |
| SESN3 | ZWILCH | 0.716084 | 3 | 0 | 3 |
| SESN3 | KCNK1 | 0.712643 | 3 | 0 | 3 |
| SESN3 | TRADD | 0.710733 | 3 | 0 | 3 |
| SESN3 | SSRP1 | 0.710085 | 3 | 0 | 3 |
| SESN3 | LRRC59 | 0.705683 | 3 | 0 | 3 |
| SESN3 | NAB1 | 0.703229 | 3 | 0 | 3 |
| SESN3 | NUP160 | 0.702566 | 3 | 0 | 3 |
| SESN3 | EPRS | 0.701616 | 3 | 0 | 3 |
For details and further investigation, click here
