ADCY3

 

Full name: adenylate cyclase 3 Alias Symbol: AC3
Type: protein-coding gene Cytoband: 2p23.3
Entrez ID: 109 HGNC ID: HGNC:234 Ensembl Gene: ENSG00000138031 OMIM ID: 600291
Drug and gene relationship at DGIdb

 

ADCY3 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04114Oocyte meiosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa04740Olfactory transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04925Aldosterone synthesis and secretion
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05032Morphine addiction
hsa05110Vibrio cholerae infection
hsa05166HTLV-I infection

 

Expression of ADCY3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADCY3 109 209320_at 0.5905 0.1010
GSE20347 ADCY3 109 209320_at 0.6609 0.0000
GSE23400 ADCY3 109 209321_s_at 0.6521 0.0000
GSE26886 ADCY3 109 209320_at 0.9037 0.0000
GSE29001 ADCY3 109 209320_at 0.4160 0.0105
GSE38129 ADCY3 109 209320_at 0.5105 0.0000
GSE45670 ADCY3 109 209320_at 0.1120 0.4211
GSE63941 ADCY3 109 209321_s_at 0.2902 0.5421
GSE77861 ADCY3 109 209320_at 0.4915 0.0017
GSE97050 ADCY3 109 A_23_P67864 0.6787 0.1143
SRP007169 ADCY3 109 RNAseq 1.5104 0.0000
SRP008496 ADCY3 109 RNAseq 1.6864 0.0000
SRP064894 ADCY3 109 RNAseq 0.6160 0.0005
SRP133303 ADCY3 109 RNAseq 0.5072 0.0062
SRP159526 ADCY3 109 RNAseq 0.9500 0.0027
SRP193095 ADCY3 109 RNAseq 1.3961 0.0000
SRP219564 ADCY3 109 RNAseq 0.7622 0.0188
TCGA ADCY3 109 RNAseq 0.2984 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by ADCY3 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of ADCY3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADCY3 109 11 2 17
GSE20123 ADCY3 109 11 2 17
GSE43470 ADCY3 109 3 1 39
GSE46452 ADCY3 109 3 4 52
GSE47630 ADCY3 109 8 0 32
GSE54993 ADCY3 109 0 6 64
GSE54994 ADCY3 109 10 0 43
GSE60625 ADCY3 109 0 3 8
GSE74703 ADCY3 109 3 0 33
GSE74704 ADCY3 109 9 1 10
TCGA ADCY3 109 36 3 57

Total number of gains: 94; Total number of losses: 22; Total Number of normals: 372.  

 

Somatic mutations of ADCY3:

 

Generating mutation plots.

 

Highly correlated genes for ADCY3:

 

Showing top 20/1828 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADCY3MRPL360.925491303
ADCY3TP53I130.829617404
ADCY3DNPEP0.811052303
ADCY3FAM89B0.809005303
ADCY3SLC39A130.799937303
ADCY3SPIRE10.797875303
ADCY3LINGO10.792683303
ADCY3THEM40.792035303
ADCY3SMCR80.783201303
ADCY3SLC37A30.782896404
ADCY3OAF0.781918303
ADCY3CCM20.781275404
ADCY3IL1B0.777362303
ADCY3OCIAD20.774414404
ADCY3CASC40.772099303
ADCY3SSBP40.771186404
ADCY3IDS0.769227303
ADCY3HERPUD20.763754303
ADCY3SAAL10.76022303
ADCY3NACC10.75552303

For details and further investigation, click here