| Full name: HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 | Alias Symbol: SUTAL|BLOC2S1 | ||
| Type: protein-coding gene | Cytoband: 3q24 | ||
| Entrez ID: 84343 | HGNC ID: HGNC:15597 | Ensembl Gene: ENSG00000163755 | OMIM ID: 606118 |
| Drug and gene relationship at DGIdb | |||
Expression of HPS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HPS3 | 84343 | 227139_s_at | 0.8200 | 0.1234 | |
| GSE26886 | HPS3 | 84343 | 227139_s_at | 0.9045 | 0.0182 | |
| GSE45670 | HPS3 | 84343 | 227139_s_at | 0.7871 | 0.0023 | |
| GSE63941 | HPS3 | 84343 | 227139_s_at | 0.1897 | 0.7541 | |
| GSE77861 | HPS3 | 84343 | 227139_s_at | 1.1794 | 0.0058 | |
| GSE97050 | HPS3 | 84343 | A_23_P40821 | 0.0469 | 0.8658 | |
| SRP007169 | HPS3 | 84343 | RNAseq | 1.4172 | 0.0033 | |
| SRP008496 | HPS3 | 84343 | RNAseq | 1.7926 | 0.0000 | |
| SRP064894 | HPS3 | 84343 | RNAseq | 1.0058 | 0.0000 | |
| SRP133303 | HPS3 | 84343 | RNAseq | 0.8523 | 0.0000 | |
| SRP159526 | HPS3 | 84343 | RNAseq | 1.0255 | 0.0065 | |
| SRP193095 | HPS3 | 84343 | RNAseq | 0.7759 | 0.0000 | |
| SRP219564 | HPS3 | 84343 | RNAseq | 1.0683 | 0.0198 | |
| TCGA | HPS3 | 84343 | RNAseq | 0.2183 | 0.0025 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by HPS3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of HPS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HPS3 | 84343 | 22 | 0 | 8 | |
| GSE20123 | HPS3 | 84343 | 22 | 0 | 8 | |
| GSE43470 | HPS3 | 84343 | 23 | 0 | 20 | |
| GSE46452 | HPS3 | 84343 | 18 | 2 | 39 | |
| GSE47630 | HPS3 | 84343 | 19 | 3 | 18 | |
| GSE54993 | HPS3 | 84343 | 1 | 10 | 59 | |
| GSE54994 | HPS3 | 84343 | 37 | 1 | 15 | |
| GSE60625 | HPS3 | 84343 | 0 | 6 | 5 | |
| GSE74703 | HPS3 | 84343 | 20 | 0 | 16 | |
| GSE74704 | HPS3 | 84343 | 15 | 0 | 5 | |
| TCGA | HPS3 | 84343 | 70 | 2 | 24 |
Total number of gains: 247; Total number of losses: 24; Total Number of normals: 217.
Somatic mutations of HPS3:
Generating mutation plots.
Highly correlated genes for HPS3:
Showing top 20/1297 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HPS3 | ELAVL1 | 0.786973 | 4 | 0 | 4 |
| HPS3 | TOPBP1 | 0.786361 | 5 | 0 | 5 |
| HPS3 | UBXN4 | 0.783861 | 3 | 0 | 3 |
| HPS3 | ATR | 0.771657 | 5 | 0 | 5 |
| HPS3 | HLTF | 0.763799 | 6 | 0 | 6 |
| HPS3 | MIS18A | 0.763253 | 3 | 0 | 3 |
| HPS3 | SUMO3 | 0.757546 | 3 | 0 | 3 |
| HPS3 | TM2D1 | 0.756744 | 3 | 0 | 3 |
| HPS3 | VPS13C | 0.754945 | 3 | 0 | 3 |
| HPS3 | STK3 | 0.754414 | 4 | 0 | 4 |
| HPS3 | EZH2 | 0.751384 | 4 | 0 | 4 |
| HPS3 | PXYLP1 | 0.748167 | 4 | 0 | 4 |
| HPS3 | RBM12 | 0.745937 | 5 | 0 | 5 |
| HPS3 | SMARCE1 | 0.745047 | 3 | 0 | 3 |
| HPS3 | CDC45 | 0.736248 | 3 | 0 | 3 |
| HPS3 | LRRC58 | 0.734633 | 5 | 0 | 5 |
| HPS3 | ZBED4 | 0.734308 | 3 | 0 | 3 |
| HPS3 | ACTR6 | 0.733965 | 4 | 0 | 4 |
| HPS3 | ZNF518B | 0.733166 | 4 | 0 | 4 |
| HPS3 | TRRAP | 0.732807 | 5 | 0 | 4 |
For details and further investigation, click here
