| Full name: coagulation factor II thrombin receptor like 2 | Alias Symbol: PAR3 | ||
| Type: protein-coding gene | Cytoband: 5q13.3 | ||
| Entrez ID: 2151 | HGNC ID: HGNC:3539 | Ensembl Gene: ENSG00000164220 | OMIM ID: 601919 |
| Drug and gene relationship at DGIdb | |||
F2RL2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance | |
| hsa04610 | Complement and coagulation cascades |
Expression of F2RL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | F2RL2 | 2151 | 230147_at | 0.8984 | 0.2653 | |
| GSE20347 | F2RL2 | 2151 | 206795_at | 0.0728 | 0.2429 | |
| GSE23400 | F2RL2 | 2151 | 206795_at | -0.0113 | 0.6143 | |
| GSE26886 | F2RL2 | 2151 | 230147_at | 1.7607 | 0.0032 | |
| GSE29001 | F2RL2 | 2151 | 206795_at | 0.0805 | 0.5409 | |
| GSE38129 | F2RL2 | 2151 | 206795_at | 0.0258 | 0.6828 | |
| GSE45670 | F2RL2 | 2151 | 230147_at | 0.5447 | 0.2006 | |
| GSE53622 | F2RL2 | 2151 | 59680 | 1.4821 | 0.0000 | |
| GSE53624 | F2RL2 | 2151 | 59680 | 1.9726 | 0.0000 | |
| GSE63941 | F2RL2 | 2151 | 230147_at | -3.6574 | 0.0041 | |
| GSE77861 | F2RL2 | 2151 | 206795_at | -0.0833 | 0.4788 | |
| GSE97050 | F2RL2 | 2151 | A_32_P60065 | 0.2315 | 0.7442 | |
| SRP007169 | F2RL2 | 2151 | RNAseq | 2.6528 | 0.0009 | |
| SRP064894 | F2RL2 | 2151 | RNAseq | 1.9935 | 0.0000 | |
| SRP133303 | F2RL2 | 2151 | RNAseq | 0.7780 | 0.0153 | |
| SRP159526 | F2RL2 | 2151 | RNAseq | 2.5334 | 0.0001 | |
| SRP193095 | F2RL2 | 2151 | RNAseq | 1.4223 | 0.0000 | |
| SRP219564 | F2RL2 | 2151 | RNAseq | 1.3757 | 0.1000 | |
| TCGA | F2RL2 | 2151 | RNAseq | 0.3919 | 0.0796 |
Upregulated datasets: 7; Downregulated datasets: 1.
Survival by F2RL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of F2RL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | F2RL2 | 2151 | 1 | 13 | 16 | |
| GSE20123 | F2RL2 | 2151 | 1 | 13 | 16 | |
| GSE43470 | F2RL2 | 2151 | 1 | 13 | 29 | |
| GSE46452 | F2RL2 | 2151 | 0 | 28 | 31 | |
| GSE47630 | F2RL2 | 2151 | 1 | 19 | 20 | |
| GSE54993 | F2RL2 | 2151 | 8 | 1 | 61 | |
| GSE54994 | F2RL2 | 2151 | 1 | 19 | 33 | |
| GSE60625 | F2RL2 | 2151 | 0 | 0 | 11 | |
| GSE74703 | F2RL2 | 2151 | 1 | 9 | 26 | |
| GSE74704 | F2RL2 | 2151 | 1 | 6 | 13 | |
| TCGA | F2RL2 | 2151 | 5 | 49 | 42 |
Total number of gains: 20; Total number of losses: 170; Total Number of normals: 298.
Somatic mutations of F2RL2:
Generating mutation plots.
Highly correlated genes for F2RL2:
Showing top 20/282 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| F2RL2 | SH3RF3 | 0.694053 | 3 | 0 | 3 |
| F2RL2 | ASPN | 0.677468 | 6 | 0 | 5 |
| F2RL2 | SIPA1L1 | 0.661416 | 3 | 0 | 3 |
| F2RL2 | FNDC1 | 0.641956 | 6 | 0 | 5 |
| F2RL2 | OR3A1 | 0.636668 | 4 | 0 | 4 |
| F2RL2 | ITGA11 | 0.631818 | 3 | 0 | 3 |
| F2RL2 | MYL1 | 0.631332 | 4 | 0 | 4 |
| F2RL2 | ANTXR1 | 0.630708 | 6 | 0 | 6 |
| F2RL2 | FOXN3-AS2 | 0.623662 | 4 | 0 | 4 |
| F2RL2 | INSL5 | 0.621034 | 4 | 0 | 3 |
| F2RL2 | NME8 | 0.619959 | 5 | 0 | 4 |
| F2RL2 | IFNA7 | 0.619479 | 5 | 0 | 5 |
| F2RL2 | OR1F1 | 0.619146 | 6 | 0 | 5 |
| F2RL2 | FCGR2C | 0.617269 | 3 | 0 | 3 |
| F2RL2 | COL5A1 | 0.615588 | 6 | 0 | 5 |
| F2RL2 | CHRM2 | 0.615068 | 7 | 0 | 6 |
| F2RL2 | NOX4 | 0.614669 | 7 | 0 | 6 |
| F2RL2 | ITGAV | 0.61373 | 5 | 0 | 5 |
| F2RL2 | KRT38 | 0.611722 | 4 | 0 | 4 |
| F2RL2 | SPATA9 | 0.610043 | 3 | 0 | 3 |
For details and further investigation, click here
