NOX4

 

Full name: NADPH oxidase 4 Alias Symbol: KOX-1|KOX
Type: protein-coding gene Cytoband: 11q14.3
Entrez ID: 50507 HGNC ID: HGNC:7891 Ensembl Gene: ENSG00000086991 OMIM ID: 605261
Drug and gene relationship at DGIdb

 

Expression of NOX4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NOX4 50507 219773_at 1.2230 0.0540
GSE20347 NOX4 50507 219773_at 0.9763 0.0000
GSE23400 NOX4 50507 219773_at 0.4578 0.0000
GSE26886 NOX4 50507 219773_at 1.5341 0.0006
GSE29001 NOX4 50507 219773_at 0.6444 0.0127
GSE38129 NOX4 50507 219773_at 1.1898 0.0000
GSE45670 NOX4 50507 219773_at 0.6711 0.1118
GSE53622 NOX4 50507 15617 2.6239 0.0000
GSE53624 NOX4 50507 15617 3.1732 0.0000
GSE63941 NOX4 50507 219773_at -3.2033 0.0000
GSE77861 NOX4 50507 219773_at 0.1109 0.5801
GSE97050 NOX4 50507 A_33_P3224324 0.6571 0.2765
SRP007169 NOX4 50507 RNAseq 6.0596 0.0000
SRP008496 NOX4 50507 RNAseq 4.1824 0.0002
SRP064894 NOX4 50507 RNAseq 3.0291 0.0000
SRP133303 NOX4 50507 RNAseq 1.8536 0.0000
SRP159526 NOX4 50507 RNAseq 2.0046 0.0099
SRP193095 NOX4 50507 RNAseq 1.6340 0.0000
SRP219564 NOX4 50507 RNAseq 2.4207 0.0000
TCGA NOX4 50507 RNAseq 2.0154 0.0000

Upregulated datasets: 12; Downregulated datasets: 1.  

 

Survival by NOX4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NOX4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NOX4 50507 3 10 17
GSE20123 NOX4 50507 3 10 17
GSE43470 NOX4 50507 3 4 36
GSE46452 NOX4 50507 6 23 30
GSE47630 NOX4 50507 2 19 19
GSE54993 NOX4 50507 8 2 60
GSE54994 NOX4 50507 5 19 29
GSE60625 NOX4 50507 0 3 8
GSE74703 NOX4 50507 2 3 31
GSE74704 NOX4 50507 3 6 11
TCGA NOX4 50507 16 38 42

Total number of gains: 51; Total number of losses: 137; Total Number of normals: 300.  

 

Somatic mutations of NOX4:

 

Generating mutation plots.

 

Highly correlated genes for NOX4:

 

Showing top 20/1026 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NOX4FAP0.79931811011
NOX4SULF10.78803712012
NOX4OLFML2B0.77762913012
NOX4PDIA50.777347303
NOX4COL5A10.75938613013
NOX4CEP1700.755938303
NOX4NID20.7552110010
NOX4DACT10.75306213012
NOX4COL10A10.74968712011
NOX4CDH110.74673512011
NOX4BGN0.74512813012
NOX4THY10.74493213013
NOX4ITGA110.743464404
NOX4POSTN0.74192513013
NOX4S1PR30.735267303
NOX4COL5A20.73458813013
NOX4VCAN0.73035613012
NOX4LINC012790.728009303
NOX4LRRC8C0.727888303
NOX4MFAP20.72713812010

For details and further investigation, click here