ITGAV

 

Full name: integrin subunit alpha V Alias Symbol: CD51
Type: protein-coding gene Cytoband: 2q32.1
Entrez ID: 3685 HGNC ID: HGNC:6150 Ensembl Gene: ENSG00000138448 OMIM ID: 193210
Drug and gene relationship at DGIdb
Screen Evidence:

 

ITGAV involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04810Regulation of actin cytoskeleton
hsa04919Thyroid hormone signaling pathway
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05222Small cell lung cancer

 

Expression of ITGAV:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ITGAV 3685 202351_at 0.7444 0.1779
GSE20347 ITGAV 3685 202351_at 1.0568 0.0001
GSE23400 ITGAV 3685 202351_at 1.0582 0.0000
GSE26886 ITGAV 3685 202351_at 1.3835 0.0000
GSE29001 ITGAV 3685 202351_at 1.1085 0.0048
GSE38129 ITGAV 3685 202351_at 1.0151 0.0000
GSE45670 ITGAV 3685 202351_at 0.5132 0.0764
GSE53622 ITGAV 3685 12561 1.1745 0.0000
GSE53624 ITGAV 3685 12561 1.1844 0.0000
GSE63941 ITGAV 3685 202351_at -2.8106 0.1652
GSE77861 ITGAV 3685 202351_at 1.4187 0.0038
GSE97050 ITGAV 3685 A_23_P50907 0.6548 0.0970
SRP007169 ITGAV 3685 RNAseq 2.3349 0.0000
SRP008496 ITGAV 3685 RNAseq 2.3671 0.0000
SRP064894 ITGAV 3685 RNAseq 1.5207 0.0000
SRP133303 ITGAV 3685 RNAseq 1.8427 0.0000
SRP159526 ITGAV 3685 RNAseq 0.8091 0.0000
SRP193095 ITGAV 3685 RNAseq 1.1108 0.0000
SRP219564 ITGAV 3685 RNAseq 0.3106 0.5268
TCGA ITGAV 3685 RNAseq 0.0754 0.2703

Upregulated datasets: 13; Downregulated datasets: 0.  

 

Survival by ITGAV expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ITGAV:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ITGAV 3685 6 1 23
GSE20123 ITGAV 3685 7 1 22
GSE43470 ITGAV 3685 3 1 39
GSE46452 ITGAV 3685 1 4 54
GSE47630 ITGAV 3685 4 5 31
GSE54993 ITGAV 3685 0 5 65
GSE54994 ITGAV 3685 12 6 35
GSE60625 ITGAV 3685 0 3 8
GSE74703 ITGAV 3685 2 1 33
GSE74704 ITGAV 3685 3 1 16
TCGA ITGAV 3685 24 9 63

Total number of gains: 62; Total number of losses: 37; Total Number of normals: 389.  

 

Somatic mutations of ITGAV:

 

Generating mutation plots.

 

Highly correlated genes for ITGAV:

 

Showing top 20/1908 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ITGAVHAS30.800788303
ITGAVTMTC10.792776303
ITGAVINHBA0.78699710010
ITGAVLRP120.77686511011
ITGAVCEP1200.776239303
ITGAVACVR10.77551813012
ITGAVSLC39A140.77032912012
ITGAVENAH0.7661212011
ITGAVCOL5A20.76166112011
ITGAVSLC39A30.75609303
ITGAVTGFBI0.75554413012
ITGAVMFAP20.75161411011
ITGAVWDR540.750181707
ITGAVXPR10.749557707
ITGAVPRNP0.74842412011
ITGAVSDHAF20.74768303
ITGAVSTAT20.747508403
ITGAVCHIC10.746166303
ITGAVCD2760.745856404
ITGAVA4GALT0.740652303

For details and further investigation, click here