| Full name: integrin subunit alpha 11 | Alias Symbol: HsT18964 | ||
| Type: protein-coding gene | Cytoband: 15q23 | ||
| Entrez ID: 22801 | HGNC ID: HGNC:6136 | Ensembl Gene: ENSG00000137809 | OMIM ID: 604789 |
| Drug and gene relationship at DGIdb | |||
ITGA11 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ITGA11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITGA11 | 22801 | 222899_at | 0.5822 | 0.4395 | |
| GSE26886 | ITGA11 | 22801 | 1554819_a_at | -0.0812 | 0.4640 | |
| GSE45670 | ITGA11 | 22801 | 1554819_a_at | 0.1104 | 0.1036 | |
| GSE53622 | ITGA11 | 22801 | 30730 | 1.1893 | 0.0000 | |
| GSE53624 | ITGA11 | 22801 | 30730 | 1.6681 | 0.0000 | |
| GSE63941 | ITGA11 | 22801 | 1554819_a_at | -0.2297 | 0.3551 | |
| GSE77861 | ITGA11 | 22801 | 1554819_a_at | -0.0527 | 0.5866 | |
| SRP007169 | ITGA11 | 22801 | RNAseq | 4.5283 | 0.0000 | |
| SRP008496 | ITGA11 | 22801 | RNAseq | 4.6204 | 0.0000 | |
| SRP064894 | ITGA11 | 22801 | RNAseq | 1.1103 | 0.0001 | |
| SRP133303 | ITGA11 | 22801 | RNAseq | 1.6176 | 0.0000 | |
| SRP159526 | ITGA11 | 22801 | RNAseq | 1.3808 | 0.0000 | |
| SRP193095 | ITGA11 | 22801 | RNAseq | 1.0444 | 0.0000 | |
| SRP219564 | ITGA11 | 22801 | RNAseq | 1.3584 | 0.0021 | |
| TCGA | ITGA11 | 22801 | RNAseq | 0.3582 | 0.0634 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by ITGA11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITGA11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITGA11 | 22801 | 7 | 1 | 22 | |
| GSE20123 | ITGA11 | 22801 | 7 | 1 | 22 | |
| GSE43470 | ITGA11 | 22801 | 4 | 6 | 33 | |
| GSE46452 | ITGA11 | 22801 | 3 | 7 | 49 | |
| GSE47630 | ITGA11 | 22801 | 8 | 10 | 22 | |
| GSE54993 | ITGA11 | 22801 | 5 | 6 | 59 | |
| GSE54994 | ITGA11 | 22801 | 5 | 7 | 41 | |
| GSE60625 | ITGA11 | 22801 | 4 | 0 | 7 | |
| GSE74703 | ITGA11 | 22801 | 4 | 3 | 29 | |
| GSE74704 | ITGA11 | 22801 | 3 | 1 | 16 | |
| TCGA | ITGA11 | 22801 | 10 | 15 | 71 |
Total number of gains: 60; Total number of losses: 57; Total Number of normals: 371.
Somatic mutations of ITGA11:
Generating mutation plots.
Highly correlated genes for ITGA11:
Showing top 20/182 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITGA11 | SFRP4 | 0.756628 | 4 | 0 | 4 |
| ITGA11 | AEBP1 | 0.751053 | 4 | 0 | 4 |
| ITGA11 | NOX4 | 0.743464 | 4 | 0 | 4 |
| ITGA11 | ADAMTS12 | 0.731086 | 3 | 0 | 3 |
| ITGA11 | GLT8D2 | 0.726112 | 4 | 0 | 4 |
| ITGA11 | PTGER3 | 0.722856 | 3 | 0 | 3 |
| ITGA11 | THY1 | 0.720192 | 4 | 0 | 4 |
| ITGA11 | ADAMTS2 | 0.716446 | 5 | 0 | 5 |
| ITGA11 | MSX2 | 0.710352 | 3 | 0 | 3 |
| ITGA11 | LOXL1 | 0.690695 | 5 | 0 | 4 |
| ITGA11 | CMTM3 | 0.679199 | 5 | 0 | 4 |
| ITGA11 | OLFML2B | 0.677357 | 5 | 0 | 4 |
| ITGA11 | LPL | 0.675903 | 3 | 0 | 3 |
| ITGA11 | TENM3 | 0.670327 | 3 | 0 | 3 |
| ITGA11 | SPON2 | 0.669379 | 3 | 0 | 3 |
| ITGA11 | P4HA1 | 0.666 | 3 | 0 | 3 |
| ITGA11 | PDGFRL | 0.665717 | 5 | 0 | 4 |
| ITGA11 | RCN3 | 0.661829 | 5 | 0 | 4 |
| ITGA11 | AIP | 0.660006 | 3 | 0 | 3 |
| ITGA11 | C1orf216 | 0.659192 | 3 | 0 | 3 |
For details and further investigation, click here
