COL5A1

 

Full name: collagen type V alpha 1 chain Alias Symbol: 
Type: protein-coding gene Cytoband: 9q34.3
Entrez ID: 1289 HGNC ID: HGNC:2209 Ensembl Gene: ENSG00000130635 OMIM ID: 120215
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of COL5A1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 COL5A1 1289 212488_at 1.3918 0.1630
GSE20347 COL5A1 1289 203325_s_at 1.8966 0.0000
GSE23400 COL5A1 1289 212488_at 1.6753 0.0000
GSE26886 COL5A1 1289 203325_s_at 3.9440 0.0000
GSE29001 COL5A1 1289 203325_s_at 1.9160 0.0000
GSE38129 COL5A1 1289 212488_at 1.6055 0.0000
GSE45670 COL5A1 1289 212488_at 0.8029 0.1919
GSE53622 COL5A1 1289 36801 2.4616 0.0000
GSE53624 COL5A1 1289 36801 2.7365 0.0000
GSE63941 COL5A1 1289 203325_s_at -3.6200 0.0168
GSE77861 COL5A1 1289 203325_s_at 0.7001 0.1770
GSE97050 COL5A1 1289 A_33_P3629678 1.4086 0.0631
SRP007169 COL5A1 1289 RNAseq 6.1895 0.0000
SRP008496 COL5A1 1289 RNAseq 5.8757 0.0000
SRP064894 COL5A1 1289 RNAseq 2.7128 0.0000
SRP133303 COL5A1 1289 RNAseq 3.2038 0.0000
SRP159526 COL5A1 1289 RNAseq 1.5093 0.0001
SRP193095 COL5A1 1289 RNAseq 3.3072 0.0000
SRP219564 COL5A1 1289 RNAseq 2.0219 0.0026
TCGA COL5A1 1289 RNAseq 0.3989 0.0011

Upregulated datasets: 14; Downregulated datasets: 1.  

 

Survival by COL5A1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of COL5A1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 COL5A1 1289 4 7 19
GSE20123 COL5A1 1289 4 7 19
GSE43470 COL5A1 1289 3 8 32
GSE46452 COL5A1 1289 6 13 40
GSE47630 COL5A1 1289 6 15 19
GSE54993 COL5A1 1289 3 3 64
GSE54994 COL5A1 1289 12 9 32
GSE60625 COL5A1 1289 0 0 11
GSE74703 COL5A1 1289 3 6 27
GSE74704 COL5A1 1289 2 5 13
TCGA COL5A1 1289 28 25 43

Total number of gains: 71; Total number of losses: 98; Total Number of normals: 319.  

 

Somatic mutations of COL5A1:

 

Generating mutation plots.

 

Highly correlated genes for COL5A1:

 

Showing top 20/1478 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
COL5A1COL5A20.90162313013
COL5A1COL1A10.86614512012
COL5A1COL6A30.86517713013
COL5A1SPARC0.86351813013
COL5A1POSTN0.85103313013
COL5A1BGN0.85091413013
COL5A1VCAN0.84918113013
COL5A1COL3A10.8466313013
COL5A1LOXL20.84552312012
COL5A1FAP0.84419911011
COL5A1COL1A20.83884313013
COL5A1THY10.83588613013
COL5A1INHBA0.82945812012
COL5A1PCOLCE0.82707913013
COL5A1HTRA10.81493113013
COL5A1CDH110.80750213012
COL5A1OLFML2B0.80551513013
COL5A1ZNF4690.805255808
COL5A1COL6A10.8014213013
COL5A1LEPR0.801171303

For details and further investigation, click here