| Full name: cholinergic receptor muscarinic 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q33 | ||
| Entrez ID: 1129 | HGNC ID: HGNC:1951 | Ensembl Gene: ENSG00000181072 | OMIM ID: 118493 |
| Drug and gene relationship at DGIdb | |||
CHRM2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04024 | cAMP signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04725 | Cholinergic synapse | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of CHRM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRM2 | 1129 | 221330_at | -0.0384 | 0.9295 | |
| GSE20347 | CHRM2 | 1129 | 221330_at | 0.0731 | 0.5249 | |
| GSE23400 | CHRM2 | 1129 | 221330_at | -0.1733 | 0.0048 | |
| GSE26886 | CHRM2 | 1129 | 221330_at | 0.0853 | 0.5206 | |
| GSE29001 | CHRM2 | 1129 | 221330_at | -0.0992 | 0.5307 | |
| GSE38129 | CHRM2 | 1129 | 221330_at | -0.1155 | 0.2348 | |
| GSE45670 | CHRM2 | 1129 | 221330_at | 0.1336 | 0.1076 | |
| GSE53622 | CHRM2 | 1129 | 91931 | -0.8013 | 0.0021 | |
| GSE53624 | CHRM2 | 1129 | 91931 | -0.0807 | 0.6597 | |
| GSE63941 | CHRM2 | 1129 | 221330_at | -2.8657 | 0.0000 | |
| GSE77861 | CHRM2 | 1129 | 221330_at | -0.0280 | 0.8610 | |
| GSE97050 | CHRM2 | 1129 | A_23_P145606 | -0.2661 | 0.6740 | |
| SRP133303 | CHRM2 | 1129 | RNAseq | 1.1739 | 0.0194 | |
| TCGA | CHRM2 | 1129 | RNAseq | -2.3683 | 0.0006 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by CHRM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRM2 | 1129 | 5 | 1 | 24 | |
| GSE20123 | CHRM2 | 1129 | 5 | 1 | 24 | |
| GSE43470 | CHRM2 | 1129 | 2 | 3 | 38 | |
| GSE46452 | CHRM2 | 1129 | 7 | 2 | 50 | |
| GSE47630 | CHRM2 | 1129 | 7 | 4 | 29 | |
| GSE54993 | CHRM2 | 1129 | 3 | 5 | 62 | |
| GSE54994 | CHRM2 | 1129 | 6 | 8 | 39 | |
| GSE60625 | CHRM2 | 1129 | 0 | 0 | 11 | |
| GSE74703 | CHRM2 | 1129 | 2 | 3 | 31 | |
| GSE74704 | CHRM2 | 1129 | 2 | 1 | 17 | |
| TCGA | CHRM2 | 1129 | 28 | 24 | 44 |
Total number of gains: 67; Total number of losses: 52; Total Number of normals: 369.
Somatic mutations of CHRM2:
Generating mutation plots.
Highly correlated genes for CHRM2:
Showing top 20/798 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRM2 | ADAMTS12 | 0.757779 | 5 | 0 | 5 |
| CHRM2 | KRT76 | 0.747983 | 4 | 0 | 4 |
| CHRM2 | NTNG1 | 0.74134 | 4 | 0 | 4 |
| CHRM2 | LINC00563 | 0.737812 | 4 | 0 | 4 |
| CHRM2 | NR4A3 | 0.732824 | 4 | 0 | 3 |
| CHRM2 | PLEKHO2 | 0.732528 | 3 | 0 | 3 |
| CHRM2 | MASP1 | 0.732094 | 5 | 0 | 5 |
| CHRM2 | USP29 | 0.724595 | 5 | 0 | 5 |
| CHRM2 | KIR2DS2 | 0.721786 | 5 | 0 | 5 |
| CHRM2 | TACR3 | 0.719685 | 5 | 0 | 5 |
| CHRM2 | ASCL3 | 0.71835 | 4 | 0 | 4 |
| CHRM2 | IL6 | 0.71728 | 3 | 0 | 3 |
| CHRM2 | TSHB | 0.717273 | 5 | 0 | 5 |
| CHRM2 | RPGRIP1 | 0.713988 | 4 | 0 | 4 |
| CHRM2 | CCZ1 | 0.712628 | 6 | 0 | 6 |
| CHRM2 | CHRNA2 | 0.711866 | 5 | 0 | 5 |
| CHRM2 | LUZP4 | 0.709063 | 6 | 0 | 6 |
| CHRM2 | MS4A5 | 0.70669 | 5 | 0 | 5 |
| CHRM2 | FOXN3-AS2 | 0.70518 | 6 | 0 | 6 |
| CHRM2 | CGA | 0.704835 | 6 | 0 | 5 |
For details and further investigation, click here
