| Full name: F-box and leucine rich repeat protein 4 | Alias Symbol: FBL4|FBL5 | ||
| Type: protein-coding gene | Cytoband: 6q16.1-q16.2 | ||
| Entrez ID: 26235 | HGNC ID: HGNC:13601 | Ensembl Gene: ENSG00000112234 | OMIM ID: 605654 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXL4 | 26235 | 209943_at | -0.0477 | 0.9267 | |
| GSE20347 | FBXL4 | 26235 | 209943_at | 0.3528 | 0.0442 | |
| GSE23400 | FBXL4 | 26235 | 209943_at | 0.2916 | 0.0000 | |
| GSE26886 | FBXL4 | 26235 | 209943_at | 0.4959 | 0.0656 | |
| GSE29001 | FBXL4 | 26235 | 209943_at | 0.6615 | 0.0070 | |
| GSE38129 | FBXL4 | 26235 | 209943_at | 0.4889 | 0.0002 | |
| GSE45670 | FBXL4 | 26235 | 209943_at | 0.4580 | 0.0060 | |
| GSE53622 | FBXL4 | 26235 | 55489 | 0.1683 | 0.0391 | |
| GSE53624 | FBXL4 | 26235 | 55489 | 0.5189 | 0.0000 | |
| GSE63941 | FBXL4 | 26235 | 209943_at | -0.7140 | 0.0686 | |
| GSE77861 | FBXL4 | 26235 | 209943_at | 0.5259 | 0.0154 | |
| GSE97050 | FBXL4 | 26235 | A_23_P214739 | 0.0870 | 0.6846 | |
| SRP007169 | FBXL4 | 26235 | RNAseq | 0.2503 | 0.5227 | |
| SRP008496 | FBXL4 | 26235 | RNAseq | 0.1387 | 0.5341 | |
| SRP064894 | FBXL4 | 26235 | RNAseq | 0.2684 | 0.1534 | |
| SRP133303 | FBXL4 | 26235 | RNAseq | 0.0400 | 0.8090 | |
| SRP159526 | FBXL4 | 26235 | RNAseq | 0.1832 | 0.6060 | |
| SRP193095 | FBXL4 | 26235 | RNAseq | -0.0354 | 0.6926 | |
| SRP219564 | FBXL4 | 26235 | RNAseq | 0.1638 | 0.5702 | |
| TCGA | FBXL4 | 26235 | RNAseq | -0.1033 | 0.0639 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FBXL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXL4 | 26235 | 1 | 3 | 26 | |
| GSE20123 | FBXL4 | 26235 | 1 | 2 | 27 | |
| GSE43470 | FBXL4 | 26235 | 3 | 0 | 40 | |
| GSE46452 | FBXL4 | 26235 | 2 | 11 | 46 | |
| GSE47630 | FBXL4 | 26235 | 8 | 6 | 26 | |
| GSE54993 | FBXL4 | 26235 | 3 | 2 | 65 | |
| GSE54994 | FBXL4 | 26235 | 8 | 8 | 37 | |
| GSE60625 | FBXL4 | 26235 | 0 | 1 | 10 | |
| GSE74703 | FBXL4 | 26235 | 2 | 0 | 34 | |
| GSE74704 | FBXL4 | 26235 | 0 | 0 | 20 | |
| TCGA | FBXL4 | 26235 | 6 | 24 | 66 |
Total number of gains: 34; Total number of losses: 57; Total Number of normals: 397.
Somatic mutations of FBXL4:
Generating mutation plots.
Highly correlated genes for FBXL4:
Showing top 20/1020 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXL4 | EIF5 | 0.783923 | 3 | 0 | 3 |
| FBXL4 | KLHL20 | 0.762498 | 3 | 0 | 3 |
| FBXL4 | TAF2 | 0.756655 | 6 | 0 | 6 |
| FBXL4 | KCNE3 | 0.751818 | 3 | 0 | 3 |
| FBXL4 | DHRSX | 0.734903 | 3 | 0 | 3 |
| FBXL4 | ARID1B | 0.732812 | 3 | 0 | 3 |
| FBXL4 | JMY | 0.723926 | 3 | 0 | 3 |
| FBXL4 | ZBED6 | 0.721883 | 3 | 0 | 3 |
| FBXL4 | DMTF1 | 0.719764 | 3 | 0 | 3 |
| FBXL4 | DNAJC27 | 0.716777 | 3 | 0 | 3 |
| FBXL4 | PAN3 | 0.714799 | 3 | 0 | 3 |
| FBXL4 | FZD6 | 0.712755 | 8 | 0 | 7 |
| FBXL4 | CWC22 | 0.710299 | 3 | 0 | 3 |
| FBXL4 | VMA21 | 0.706282 | 4 | 0 | 3 |
| FBXL4 | EXOC6 | 0.704546 | 4 | 0 | 3 |
| FBXL4 | TCEAL4 | 0.70443 | 3 | 0 | 3 |
| FBXL4 | C20orf194 | 0.702779 | 3 | 0 | 3 |
| FBXL4 | DPY19L2 | 0.702221 | 3 | 0 | 3 |
| FBXL4 | KLHL15 | 0.701905 | 3 | 0 | 3 |
| FBXL4 | RRP15 | 0.701456 | 8 | 0 | 8 |
For details and further investigation, click here
