FZD6

 

Full name: frizzled class receptor 6 Alias Symbol: Hfz6
Type: protein-coding gene Cytoband: 8q22.3
Entrez ID: 8323 HGNC ID: HGNC:4044 Ensembl Gene: ENSG00000164930 OMIM ID: 603409
Drug and gene relationship at DGIdb

 

FZD6 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05217Basal cell carcinoma

 

Expression of FZD6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FZD6 8323 203987_at 1.6088 0.0132
GSE20347 FZD6 8323 203987_at 1.4061 0.0000
GSE23400 FZD6 8323 203987_at 1.7512 0.0000
GSE26886 FZD6 8323 203987_at 0.7021 0.0177
GSE29001 FZD6 8323 203987_at 1.7013 0.0023
GSE38129 FZD6 8323 203987_at 1.5357 0.0000
GSE45670 FZD6 8323 203987_at 1.0666 0.0001
GSE63941 FZD6 8323 203987_at 0.1164 0.8338
GSE77861 FZD6 8323 203987_at 1.5669 0.0120
GSE97050 FZD6 8323 A_33_P3409392 0.9187 0.0555
SRP007169 FZD6 8323 RNAseq 0.9347 0.0227
SRP008496 FZD6 8323 RNAseq 1.1822 0.0000
SRP064894 FZD6 8323 RNAseq 1.3187 0.0000
SRP133303 FZD6 8323 RNAseq 1.2589 0.0000
SRP159526 FZD6 8323 RNAseq 1.2623 0.0004
SRP193095 FZD6 8323 RNAseq 1.2332 0.0000
SRP219564 FZD6 8323 RNAseq 1.0656 0.0006
TCGA FZD6 8323 RNAseq 0.4960 0.0000

Upregulated datasets: 13; Downregulated datasets: 0.  

 

Survival by FZD6 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of FZD6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FZD6 8323 16 0 14
GSE20123 FZD6 8323 18 0 12
GSE43470 FZD6 8323 22 0 21
GSE46452 FZD6 8323 24 0 35
GSE47630 FZD6 8323 24 0 16
GSE54993 FZD6 8323 0 20 50
GSE54994 FZD6 8323 37 1 15
GSE60625 FZD6 8323 0 4 7
GSE74703 FZD6 8323 19 0 17
GSE74704 FZD6 8323 11 0 9
TCGA FZD6 8323 60 1 35

Total number of gains: 231; Total number of losses: 26; Total Number of normals: 231.  

 

Somatic mutations of FZD6:

 

Generating mutation plots.

 

Highly correlated genes for FZD6:

 

Showing top 20/2053 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FZD6CCDC180.824543404
FZD6ECT20.810919808
FZD6WDR50.803801403
FZD6FAM161A0.798529303
FZD6TSEN150.795243404
FZD6UHMK10.793285505
FZD6CENPV0.789353303
FZD6ZNF4510.786482303
FZD6TMTC40.784218404
FZD6HJURP0.784083808
FZD6DDX550.780938404
FZD6C12orf570.777195303
FZD6GATAD2A0.776531303
FZD6QSOX20.776351404
FZD6NFKB20.775715303
FZD6COL7A10.775498606
FZD6CDKN30.772962908
FZD6TMEM1380.77283504
FZD6KNTC10.772273808
FZD6PPP1R16A0.770755303

For details and further investigation, click here