| Full name: exocyst complex component 6 | Alias Symbol: SEC15L|FLJ1125|DKFZp761I2124|MGC33397|Sec15p|EXOC6A | ||
| Type: protein-coding gene | Cytoband: 10q23.33 | ||
| Entrez ID: 54536 | HGNC ID: HGNC:23196 | Ensembl Gene: ENSG00000138190 | OMIM ID: 609672 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXOC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOC6 | 54536 | 226259_at | 0.2461 | 0.6120 | |
| GSE26886 | EXOC6 | 54536 | 226259_at | 0.7812 | 0.0094 | |
| GSE45670 | EXOC6 | 54536 | 226259_at | -0.0504 | 0.8925 | |
| GSE53622 | EXOC6 | 54536 | 73412 | 0.0810 | 0.4115 | |
| GSE53624 | EXOC6 | 54536 | 73412 | 0.2315 | 0.0045 | |
| GSE63941 | EXOC6 | 54536 | 226259_at | -0.3645 | 0.3732 | |
| GSE77861 | EXOC6 | 54536 | 226259_at | 0.6210 | 0.0074 | |
| GSE97050 | EXOC6 | 54536 | A_32_P58280 | 0.1770 | 0.6318 | |
| SRP007169 | EXOC6 | 54536 | RNAseq | 1.8439 | 0.0015 | |
| SRP008496 | EXOC6 | 54536 | RNAseq | 2.1528 | 0.0000 | |
| SRP064894 | EXOC6 | 54536 | RNAseq | 0.2801 | 0.0811 | |
| SRP133303 | EXOC6 | 54536 | RNAseq | 0.4350 | 0.0803 | |
| SRP159526 | EXOC6 | 54536 | RNAseq | 0.8115 | 0.1218 | |
| SRP193095 | EXOC6 | 54536 | RNAseq | 0.2337 | 0.2798 | |
| SRP219564 | EXOC6 | 54536 | RNAseq | 0.4940 | 0.2650 | |
| TCGA | EXOC6 | 54536 | RNAseq | -0.1590 | 0.0445 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by EXOC6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOC6 | 54536 | 2 | 7 | 21 | |
| GSE20123 | EXOC6 | 54536 | 2 | 6 | 22 | |
| GSE43470 | EXOC6 | 54536 | 0 | 8 | 35 | |
| GSE46452 | EXOC6 | 54536 | 0 | 11 | 48 | |
| GSE47630 | EXOC6 | 54536 | 2 | 14 | 24 | |
| GSE54993 | EXOC6 | 54536 | 7 | 0 | 63 | |
| GSE54994 | EXOC6 | 54536 | 1 | 10 | 42 | |
| GSE60625 | EXOC6 | 54536 | 0 | 0 | 11 | |
| GSE74703 | EXOC6 | 54536 | 0 | 6 | 30 | |
| GSE74704 | EXOC6 | 54536 | 0 | 4 | 16 | |
| TCGA | EXOC6 | 54536 | 7 | 27 | 62 |
Total number of gains: 21; Total number of losses: 93; Total Number of normals: 374.
Somatic mutations of EXOC6:
Generating mutation plots.
Highly correlated genes for EXOC6:
Showing top 20/718 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOC6 | GPATCH2 | 0.827859 | 3 | 0 | 3 |
| EXOC6 | TSFM | 0.825205 | 3 | 0 | 3 |
| EXOC6 | BABAM1 | 0.816668 | 3 | 0 | 3 |
| EXOC6 | KHSRP | 0.815917 | 3 | 0 | 3 |
| EXOC6 | WTAP | 0.814046 | 3 | 0 | 3 |
| EXOC6 | TAF2 | 0.80836 | 3 | 0 | 3 |
| EXOC6 | ZNF7 | 0.805589 | 3 | 0 | 3 |
| EXOC6 | CDC37 | 0.803765 | 3 | 0 | 3 |
| EXOC6 | PRMT1 | 0.800411 | 3 | 0 | 3 |
| EXOC6 | MED26 | 0.797911 | 3 | 0 | 3 |
| EXOC6 | FAM32A | 0.792623 | 3 | 0 | 3 |
| EXOC6 | OLA1 | 0.791375 | 3 | 0 | 3 |
| EXOC6 | KANSL2 | 0.785553 | 3 | 0 | 3 |
| EXOC6 | FARSA | 0.784581 | 3 | 0 | 3 |
| EXOC6 | NOP58 | 0.772633 | 3 | 0 | 3 |
| EXOC6 | ABCF1 | 0.772023 | 3 | 0 | 3 |
| EXOC6 | SF1 | 0.770406 | 3 | 0 | 3 |
| EXOC6 | SUPT16H | 0.768655 | 3 | 0 | 3 |
| EXOC6 | C5orf51 | 0.76094 | 3 | 0 | 3 |
| EXOC6 | FBXO5 | 0.759908 | 3 | 0 | 3 |
For details and further investigation, click here
