| Full name: fibroblast growth factor 23 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p13.32 | ||
| Entrez ID: 8074 | HGNC ID: HGNC:3680 | Ensembl Gene: ENSG00000118972 | OMIM ID: 605380 |
| Drug and gene relationship at DGIdb | |||
FGF23 involved pathways:
Expression of FGF23:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGF23 | 8074 | 221166_at | -0.0703 | 0.7870 | |
| GSE20347 | FGF23 | 8074 | 221166_at | -0.1048 | 0.1772 | |
| GSE23400 | FGF23 | 8074 | 221166_at | -0.1666 | 0.0000 | |
| GSE26886 | FGF23 | 8074 | 221166_at | -0.1755 | 0.1283 | |
| GSE29001 | FGF23 | 8074 | 221166_at | -0.2084 | 0.2099 | |
| GSE38129 | FGF23 | 8074 | 221166_at | -0.1778 | 0.0016 | |
| GSE45670 | FGF23 | 8074 | 221166_at | 0.0060 | 0.9545 | |
| GSE53622 | FGF23 | 8074 | 8859 | 0.2663 | 0.0504 | |
| GSE53624 | FGF23 | 8074 | 8859 | 0.2472 | 0.0074 | |
| GSE63941 | FGF23 | 8074 | 221166_at | -0.0575 | 0.6690 | |
| GSE77861 | FGF23 | 8074 | 221166_at | -0.1938 | 0.0601 | |
| SRP133303 | FGF23 | 8074 | RNAseq | 0.1651 | 0.3438 | |
| SRP193095 | FGF23 | 8074 | RNAseq | -0.0806 | 0.7814 | |
| SRP219564 | FGF23 | 8074 | RNAseq | 0.3742 | 0.5358 | |
| TCGA | FGF23 | 8074 | RNAseq | 3.1964 | 0.0486 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by FGF23 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGF23:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGF23 | 8074 | 6 | 4 | 20 | |
| GSE20123 | FGF23 | 8074 | 6 | 4 | 20 | |
| GSE43470 | FGF23 | 8074 | 10 | 3 | 30 | |
| GSE46452 | FGF23 | 8074 | 10 | 1 | 48 | |
| GSE47630 | FGF23 | 8074 | 12 | 2 | 26 | |
| GSE54993 | FGF23 | 8074 | 1 | 10 | 59 | |
| GSE54994 | FGF23 | 8074 | 10 | 2 | 41 | |
| GSE60625 | FGF23 | 8074 | 0 | 1 | 10 | |
| GSE74703 | FGF23 | 8074 | 9 | 2 | 25 | |
| GSE74704 | FGF23 | 8074 | 4 | 2 | 14 | |
| TCGA | FGF23 | 8074 | 40 | 6 | 50 |
Total number of gains: 108; Total number of losses: 37; Total Number of normals: 343.
Somatic mutations of FGF23:
Generating mutation plots.
Highly correlated genes for FGF23:
Showing top 20/1298 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGF23 | MAPK4 | 0.747608 | 4 | 0 | 4 |
| FGF23 | CABP1 | 0.709796 | 3 | 0 | 3 |
| FGF23 | CDH20 | 0.709673 | 3 | 0 | 3 |
| FGF23 | CYP19A1 | 0.708211 | 4 | 0 | 4 |
| FGF23 | CDHR5 | 0.705866 | 4 | 0 | 4 |
| FGF23 | RABEP2 | 0.704463 | 3 | 0 | 3 |
| FGF23 | GRIP2 | 0.704143 | 5 | 0 | 5 |
| FGF23 | CHST4 | 0.703363 | 4 | 0 | 4 |
| FGF23 | ASCL3 | 0.702953 | 7 | 0 | 7 |
| FGF23 | GPR4 | 0.701965 | 3 | 0 | 3 |
| FGF23 | PAPOLB | 0.701764 | 3 | 0 | 3 |
| FGF23 | CCDC7 | 0.700846 | 5 | 0 | 4 |
| FGF23 | TAPT1 | 0.696854 | 5 | 0 | 5 |
| FGF23 | CLEC10A | 0.691794 | 3 | 0 | 3 |
| FGF23 | CIITA | 0.691057 | 6 | 0 | 6 |
| FGF23 | GNRHR | 0.690729 | 4 | 0 | 4 |
| FGF23 | CDH7 | 0.689514 | 5 | 0 | 5 |
| FGF23 | ASIC4 | 0.687397 | 4 | 0 | 4 |
| FGF23 | ENHO | 0.68728 | 4 | 0 | 4 |
| FGF23 | CYLC1 | 0.68683 | 4 | 0 | 4 |
For details and further investigation, click here
