| Full name: G protein-coupled receptor 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 2828 | HGNC ID: HGNC:4497 | Ensembl Gene: ENSG00000177464 | OMIM ID: 600551 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR4 | 2828 | 206236_at | 0.4882 | 0.3490 | |
| GSE20347 | GPR4 | 2828 | 211266_s_at | 0.0144 | 0.8827 | |
| GSE23400 | GPR4 | 2828 | 211266_s_at | -0.1244 | 0.0024 | |
| GSE26886 | GPR4 | 2828 | 211266_s_at | 0.0512 | 0.7995 | |
| GSE29001 | GPR4 | 2828 | 211266_s_at | -0.2156 | 0.1665 | |
| GSE38129 | GPR4 | 2828 | 206236_at | 0.1460 | 0.2869 | |
| GSE45670 | GPR4 | 2828 | 206236_at | 0.1858 | 0.2938 | |
| GSE53622 | GPR4 | 2828 | 50231 | 0.3838 | 0.0079 | |
| GSE53624 | GPR4 | 2828 | 50231 | 0.7646 | 0.0000 | |
| GSE63941 | GPR4 | 2828 | 211266_s_at | 0.4241 | 0.0234 | |
| GSE77861 | GPR4 | 2828 | 206236_at | 0.0953 | 0.4718 | |
| GSE97050 | GPR4 | 2828 | A_23_P357284 | 0.3643 | 0.2525 | |
| SRP064894 | GPR4 | 2828 | RNAseq | 1.3407 | 0.0001 | |
| SRP133303 | GPR4 | 2828 | RNAseq | 0.4587 | 0.0010 | |
| SRP159526 | GPR4 | 2828 | RNAseq | 1.0947 | 0.0106 | |
| SRP193095 | GPR4 | 2828 | RNAseq | 0.6332 | 0.0000 | |
| SRP219564 | GPR4 | 2828 | RNAseq | 0.6193 | 0.2629 | |
| TCGA | GPR4 | 2828 | RNAseq | -0.1120 | 0.3354 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by GPR4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR4 | 2828 | 4 | 5 | 21 | |
| GSE20123 | GPR4 | 2828 | 4 | 4 | 22 | |
| GSE43470 | GPR4 | 2828 | 3 | 11 | 29 | |
| GSE46452 | GPR4 | 2828 | 45 | 1 | 13 | |
| GSE47630 | GPR4 | 2828 | 8 | 7 | 25 | |
| GSE54993 | GPR4 | 2828 | 17 | 4 | 49 | |
| GSE54994 | GPR4 | 2828 | 6 | 12 | 35 | |
| GSE60625 | GPR4 | 2828 | 9 | 0 | 2 | |
| GSE74703 | GPR4 | 2828 | 3 | 7 | 26 | |
| GSE74704 | GPR4 | 2828 | 4 | 2 | 14 | |
| TCGA | GPR4 | 2828 | 15 | 16 | 65 |
Total number of gains: 118; Total number of losses: 69; Total Number of normals: 301.
Somatic mutations of GPR4:
Generating mutation plots.
Highly correlated genes for GPR4:
Showing top 20/551 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR4 | TTR | 0.749808 | 3 | 0 | 3 |
| GPR4 | BCAN | 0.739742 | 4 | 0 | 4 |
| GPR4 | ATN1 | 0.720219 | 4 | 0 | 4 |
| GPR4 | NEUROD4 | 0.714896 | 4 | 0 | 4 |
| GPR4 | C5AR1 | 0.705008 | 5 | 0 | 5 |
| GPR4 | ZMAT4 | 0.704841 | 3 | 0 | 3 |
| GPR4 | FGF23 | 0.701965 | 3 | 0 | 3 |
| GPR4 | LRTM1 | 0.700261 | 4 | 0 | 4 |
| GPR4 | ZNF280B | 0.696056 | 3 | 0 | 3 |
| GPR4 | OR10J1 | 0.694335 | 3 | 0 | 3 |
| GPR4 | UTS2R | 0.689633 | 3 | 0 | 3 |
| GPR4 | SGK2 | 0.681972 | 4 | 0 | 4 |
| GPR4 | ADAMTS4 | 0.678976 | 4 | 0 | 4 |
| GPR4 | CHRNA5 | 0.671273 | 5 | 0 | 4 |
| GPR4 | KHDRBS2 | 0.67088 | 4 | 0 | 4 |
| GPR4 | CD300E | 0.668278 | 3 | 0 | 3 |
| GPR4 | IFT122 | 0.667598 | 4 | 0 | 3 |
| GPR4 | GUCA2B | 0.664822 | 3 | 0 | 3 |
| GPR4 | AMHR2 | 0.664106 | 6 | 0 | 5 |
| GPR4 | ZNF446 | 0.660521 | 4 | 0 | 4 |
For details and further investigation, click here
