| Full name: mitogen-activated protein kinase 4 | Alias Symbol: Erk3-related|Erk4 | ||
| Type: protein-coding gene | Cytoband: 18q21.1-q21.2 | ||
| Entrez ID: 5596 | HGNC ID: HGNC:6878 | Ensembl Gene: ENSG00000141639 | OMIM ID: 176949 |
| Drug and gene relationship at DGIdb | |||
Expression of MAPK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAPK4 | 5596 | 204707_s_at | -0.0857 | 0.7181 | |
| GSE20347 | MAPK4 | 5596 | 204707_s_at | 0.0044 | 0.9480 | |
| GSE23400 | MAPK4 | 5596 | 204708_at | -0.0974 | 0.0064 | |
| GSE26886 | MAPK4 | 5596 | 204707_s_at | 0.5678 | 0.0000 | |
| GSE29001 | MAPK4 | 5596 | 204708_at | -0.0349 | 0.7781 | |
| GSE38129 | MAPK4 | 5596 | 204707_s_at | -0.0636 | 0.2534 | |
| GSE45670 | MAPK4 | 5596 | 204707_s_at | -0.0275 | 0.8032 | |
| GSE53622 | MAPK4 | 5596 | 33800 | 0.0037 | 0.9627 | |
| GSE53624 | MAPK4 | 5596 | 33800 | -0.0438 | 0.6478 | |
| GSE63941 | MAPK4 | 5596 | 204707_s_at | 0.0624 | 0.7248 | |
| GSE77861 | MAPK4 | 5596 | 204707_s_at | 0.0450 | 0.7708 | |
| SRP064894 | MAPK4 | 5596 | RNAseq | -2.2562 | 0.0000 | |
| SRP133303 | MAPK4 | 5596 | RNAseq | -1.4681 | 0.0309 | |
| SRP159526 | MAPK4 | 5596 | RNAseq | -0.0549 | 0.9414 | |
| SRP219564 | MAPK4 | 5596 | RNAseq | -1.1366 | 0.2645 | |
| TCGA | MAPK4 | 5596 | RNAseq | -1.2190 | 0.0185 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by MAPK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAPK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAPK4 | 5596 | 1 | 9 | 20 | |
| GSE20123 | MAPK4 | 5596 | 1 | 9 | 20 | |
| GSE43470 | MAPK4 | 5596 | 0 | 4 | 39 | |
| GSE46452 | MAPK4 | 5596 | 1 | 26 | 32 | |
| GSE47630 | MAPK4 | 5596 | 5 | 20 | 15 | |
| GSE54993 | MAPK4 | 5596 | 9 | 0 | 61 | |
| GSE54994 | MAPK4 | 5596 | 1 | 17 | 35 | |
| GSE60625 | MAPK4 | 5596 | 0 | 4 | 7 | |
| GSE74703 | MAPK4 | 5596 | 0 | 4 | 32 | |
| GSE74704 | MAPK4 | 5596 | 1 | 6 | 13 | |
| TCGA | MAPK4 | 5596 | 9 | 44 | 43 |
Total number of gains: 28; Total number of losses: 143; Total Number of normals: 317.
Somatic mutations of MAPK4:
Generating mutation plots.
Highly correlated genes for MAPK4:
Showing top 20/839 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAPK4 | SLC22A2 | 0.790752 | 3 | 0 | 3 |
| MAPK4 | CCDC30 | 0.748393 | 3 | 0 | 3 |
| MAPK4 | FGF23 | 0.747608 | 4 | 0 | 4 |
| MAPK4 | RHAG | 0.737796 | 4 | 0 | 4 |
| MAPK4 | IFNA5 | 0.723338 | 3 | 0 | 3 |
| MAPK4 | DNAAF1 | 0.703336 | 3 | 0 | 3 |
| MAPK4 | EVX1 | 0.700211 | 6 | 0 | 6 |
| MAPK4 | RBM17 | 0.694956 | 3 | 0 | 3 |
| MAPK4 | KLK14 | 0.69477 | 3 | 0 | 3 |
| MAPK4 | PRAMEF12 | 0.694565 | 4 | 0 | 3 |
| MAPK4 | EDDM3A | 0.692788 | 3 | 0 | 3 |
| MAPK4 | WDR62 | 0.689989 | 3 | 0 | 3 |
| MAPK4 | ASCL3 | 0.689826 | 3 | 0 | 3 |
| MAPK4 | SERPIND1 | 0.68831 | 3 | 0 | 3 |
| MAPK4 | PEX5L | 0.680164 | 3 | 0 | 3 |
| MAPK4 | TAS2R3 | 0.678004 | 3 | 0 | 3 |
| MAPK4 | RSPH9 | 0.677728 | 4 | 0 | 3 |
| MAPK4 | HUNK | 0.677564 | 3 | 0 | 3 |
| MAPK4 | PANX2 | 0.675046 | 4 | 0 | 4 |
| MAPK4 | MGAT5B | 0.671903 | 3 | 0 | 3 |
For details and further investigation, click here
