| Full name: gonadotropin releasing hormone receptor | Alias Symbol: LHRHR | ||
| Type: protein-coding gene | Cytoband: 4q13.2 | ||
| Entrez ID: 2798 | HGNC ID: HGNC:4421 | Ensembl Gene: ENSG00000109163 | OMIM ID: 138850 |
| Drug and gene relationship at DGIdb | |||
GNRHR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04912 | GnRH signaling pathway |
Expression of GNRHR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNRHR | 2798 | 216341_s_at | -0.0174 | 0.9798 | |
| GSE20347 | GNRHR | 2798 | 216341_s_at | -0.1279 | 0.1591 | |
| GSE23400 | GNRHR | 2798 | 216341_s_at | -0.1865 | 0.0004 | |
| GSE26886 | GNRHR | 2798 | 216341_s_at | -0.1305 | 0.3033 | |
| GSE29001 | GNRHR | 2798 | 216341_s_at | -0.2821 | 0.3708 | |
| GSE38129 | GNRHR | 2798 | 216341_s_at | -0.2138 | 0.0089 | |
| GSE45670 | GNRHR | 2798 | 216341_s_at | 0.1834 | 0.0918 | |
| GSE63941 | GNRHR | 2798 | 216341_s_at | 0.1710 | 0.2674 | |
| GSE77861 | GNRHR | 2798 | 211523_at | -0.1013 | 0.3079 | |
| SRP007169 | GNRHR | 2798 | RNAseq | -2.1177 | 0.0002 | |
| SRP133303 | GNRHR | 2798 | RNAseq | -0.1761 | 0.5507 | |
| SRP159526 | GNRHR | 2798 | RNAseq | -2.9720 | 0.0003 | |
| SRP193095 | GNRHR | 2798 | RNAseq | -0.2303 | 0.2953 | |
| TCGA | GNRHR | 2798 | RNAseq | 0.1201 | 0.6881 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GNRHR expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GNRHR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNRHR | 2798 | 2 | 11 | 17 | |
| GSE20123 | GNRHR | 2798 | 2 | 12 | 16 | |
| GSE43470 | GNRHR | 2798 | 0 | 13 | 30 | |
| GSE46452 | GNRHR | 2798 | 2 | 35 | 22 | |
| GSE47630 | GNRHR | 2798 | 0 | 19 | 21 | |
| GSE54993 | GNRHR | 2798 | 7 | 0 | 63 | |
| GSE54994 | GNRHR | 2798 | 1 | 9 | 43 | |
| GSE60625 | GNRHR | 2798 | 0 | 0 | 11 | |
| GSE74703 | GNRHR | 2798 | 0 | 11 | 25 | |
| GSE74704 | GNRHR | 2798 | 1 | 8 | 11 | |
| TCGA | GNRHR | 2798 | 18 | 26 | 52 |
Total number of gains: 33; Total number of losses: 144; Total Number of normals: 311.
Somatic mutations of GNRHR:
Generating mutation plots.
Highly correlated genes for GNRHR:
Showing top 20/668 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNRHR | STXBP6 | 0.738602 | 3 | 0 | 3 |
| GNRHR | KRT76 | 0.731274 | 4 | 0 | 4 |
| GNRHR | SPTA1 | 0.716484 | 3 | 0 | 3 |
| GNRHR | PIWIL2 | 0.711499 | 5 | 0 | 5 |
| GNRHR | ADCYAP1 | 0.710935 | 4 | 0 | 4 |
| GNRHR | SLC6A5 | 0.70299 | 3 | 0 | 3 |
| GNRHR | SCGB1D1 | 0.698687 | 3 | 0 | 3 |
| GNRHR | IL9R | 0.693156 | 5 | 0 | 5 |
| GNRHR | CCDC7 | 0.691517 | 4 | 0 | 4 |
| GNRHR | FGF23 | 0.690729 | 4 | 0 | 4 |
| GNRHR | STXBP5L | 0.685853 | 3 | 0 | 3 |
| GNRHR | IFNA7 | 0.685054 | 4 | 0 | 3 |
| GNRHR | IFNA21 | 0.683511 | 4 | 0 | 4 |
| GNRHR | OR10J1 | 0.682101 | 4 | 0 | 4 |
| GNRHR | TAS2R16 | 0.676879 | 4 | 0 | 4 |
| GNRHR | UGT2A3 | 0.674065 | 3 | 0 | 3 |
| GNRHR | MYH8 | 0.670249 | 3 | 0 | 3 |
| GNRHR | LINC00563 | 0.668236 | 5 | 0 | 5 |
| GNRHR | GALNT8 | 0.667312 | 4 | 0 | 4 |
| GNRHR | F5 | 0.665869 | 3 | 0 | 3 |
For details and further investigation, click here
