| Full name: forkhead box A3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 3171 | HGNC ID: HGNC:5023 | Ensembl Gene: ENSG00000170608 | OMIM ID: 602295 |
| Drug and gene relationship at DGIdb | |||
FOXA3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of FOXA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FOXA3 | 3171 | 228463_at | -0.0257 | 0.9385 | |
| GSE26886 | FOXA3 | 3171 | 228463_at | 0.9136 | 0.0012 | |
| GSE45670 | FOXA3 | 3171 | 228463_at | 0.1078 | 0.5539 | |
| GSE53622 | FOXA3 | 3171 | 105086 | 0.0987 | 0.3722 | |
| GSE53624 | FOXA3 | 3171 | 105086 | -0.3839 | 0.0003 | |
| GSE63941 | FOXA3 | 3171 | 228463_at | 0.0917 | 0.7172 | |
| GSE77861 | FOXA3 | 3171 | 228463_at | -0.0295 | 0.8094 | |
| GSE97050 | FOXA3 | 3171 | A_23_P142174 | -0.0209 | 0.9376 | |
| TCGA | FOXA3 | 3171 | RNAseq | -2.8839 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FOXA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FOXA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FOXA3 | 3171 | 4 | 5 | 21 | |
| GSE20123 | FOXA3 | 3171 | 4 | 4 | 22 | |
| GSE43470 | FOXA3 | 3171 | 3 | 11 | 29 | |
| GSE46452 | FOXA3 | 3171 | 45 | 1 | 13 | |
| GSE47630 | FOXA3 | 3171 | 8 | 7 | 25 | |
| GSE54993 | FOXA3 | 3171 | 17 | 4 | 49 | |
| GSE54994 | FOXA3 | 3171 | 5 | 13 | 35 | |
| GSE60625 | FOXA3 | 3171 | 9 | 0 | 2 | |
| GSE74703 | FOXA3 | 3171 | 3 | 7 | 26 | |
| GSE74704 | FOXA3 | 3171 | 4 | 2 | 14 | |
| TCGA | FOXA3 | 3171 | 16 | 15 | 65 |
Total number of gains: 118; Total number of losses: 69; Total Number of normals: 301.
Somatic mutations of FOXA3:
Generating mutation plots.
Highly correlated genes for FOXA3:
Showing top 20/321 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FOXA3 | LRIT1 | 0.874979 | 3 | 0 | 3 |
| FOXA3 | YY2 | 0.857423 | 3 | 0 | 3 |
| FOXA3 | OR2T27 | 0.839577 | 3 | 0 | 3 |
| FOXA3 | TXNDC2 | 0.834316 | 3 | 0 | 3 |
| FOXA3 | WDR87 | 0.828264 | 3 | 0 | 3 |
| FOXA3 | GRIK4 | 0.826399 | 3 | 0 | 3 |
| FOXA3 | MYOZ3 | 0.819179 | 3 | 0 | 3 |
| FOXA3 | STRC | 0.81756 | 3 | 0 | 3 |
| FOXA3 | TMEM229A | 0.814129 | 3 | 0 | 3 |
| FOXA3 | PRSS38 | 0.813916 | 3 | 0 | 3 |
| FOXA3 | TNFAIP8L1 | 0.812109 | 4 | 0 | 4 |
| FOXA3 | DOK7 | 0.801039 | 3 | 0 | 3 |
| FOXA3 | TMEM105 | 0.800092 | 3 | 0 | 3 |
| FOXA3 | BEST4 | 0.796158 | 3 | 0 | 3 |
| FOXA3 | C20orf85 | 0.794539 | 3 | 0 | 3 |
| FOXA3 | SCARA5 | 0.793702 | 3 | 0 | 3 |
| FOXA3 | BSX | 0.79349 | 3 | 0 | 3 |
| FOXA3 | FBRSL1 | 0.793235 | 4 | 0 | 4 |
| FOXA3 | ST8SIA1 | 0.792187 | 4 | 0 | 4 |
| FOXA3 | PLA2G2C | 0.79036 | 3 | 0 | 3 |
For details and further investigation, click here
