| Full name: bestrophin 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 266675 | HGNC ID: HGNC:17106 | Ensembl Gene: ENSG00000142959 | OMIM ID: 607336 |
| Drug and gene relationship at DGIdb | |||
Expression of BEST4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BEST4 | 266675 | 1552296_at | -0.0165 | 0.9577 | |
| GSE26886 | BEST4 | 266675 | 1552296_at | -0.3234 | 0.0052 | |
| GSE45670 | BEST4 | 266675 | 1552296_at | 0.0100 | 0.9314 | |
| GSE53622 | BEST4 | 266675 | 108085 | -0.1806 | 0.0307 | |
| GSE53624 | BEST4 | 266675 | 108085 | -0.4421 | 0.0000 | |
| GSE63941 | BEST4 | 266675 | 1552296_at | 0.0316 | 0.8967 | |
| GSE77861 | BEST4 | 266675 | 1552296_at | -0.2521 | 0.0197 | |
| GSE97050 | BEST4 | 266675 | A_33_P3244808 | -0.1124 | 0.5984 | |
| SRP133303 | BEST4 | 266675 | RNAseq | 0.2337 | 0.3522 | |
| SRP159526 | BEST4 | 266675 | RNAseq | 2.0689 | 0.0023 | |
| SRP219564 | BEST4 | 266675 | RNAseq | -0.0277 | 0.9457 | |
| TCGA | BEST4 | 266675 | RNAseq | 0.9771 | 0.0249 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by BEST4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BEST4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BEST4 | 266675 | 4 | 3 | 23 | |
| GSE20123 | BEST4 | 266675 | 4 | 2 | 24 | |
| GSE43470 | BEST4 | 266675 | 7 | 2 | 34 | |
| GSE46452 | BEST4 | 266675 | 2 | 1 | 56 | |
| GSE47630 | BEST4 | 266675 | 9 | 3 | 28 | |
| GSE54993 | BEST4 | 266675 | 0 | 1 | 69 | |
| GSE54994 | BEST4 | 266675 | 13 | 2 | 38 | |
| GSE60625 | BEST4 | 266675 | 0 | 0 | 11 | |
| GSE74703 | BEST4 | 266675 | 6 | 1 | 29 | |
| GSE74704 | BEST4 | 266675 | 2 | 0 | 18 | |
| TCGA | BEST4 | 266675 | 13 | 16 | 67 |
Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.
Somatic mutations of BEST4:
Generating mutation plots.
Highly correlated genes for BEST4:
Showing top 20/299 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BEST4 | FOXA3 | 0.796158 | 3 | 0 | 3 |
| BEST4 | TDGF1 | 0.782133 | 3 | 0 | 3 |
| BEST4 | SAMD4A | 0.781789 | 3 | 0 | 3 |
| BEST4 | GAB2 | 0.779313 | 3 | 0 | 3 |
| BEST4 | LRIT1 | 0.779176 | 3 | 0 | 3 |
| BEST4 | YY2 | 0.773782 | 3 | 0 | 3 |
| BEST4 | GDF7 | 0.773372 | 3 | 0 | 3 |
| BEST4 | PHF7 | 0.770465 | 3 | 0 | 3 |
| BEST4 | PRSS38 | 0.765608 | 3 | 0 | 3 |
| BEST4 | SALL3 | 0.757224 | 3 | 0 | 3 |
| BEST4 | OTOG | 0.752322 | 3 | 0 | 3 |
| BEST4 | GRIK4 | 0.743256 | 3 | 0 | 3 |
| BEST4 | OR2T27 | 0.741053 | 3 | 0 | 3 |
| BEST4 | DCDC1 | 0.736636 | 3 | 0 | 3 |
| BEST4 | RASL10B | 0.736063 | 3 | 0 | 3 |
| BEST4 | PABPN1L | 0.734658 | 3 | 0 | 3 |
| BEST4 | ADM2 | 0.73339 | 3 | 0 | 3 |
| BEST4 | PAX6 | 0.730738 | 3 | 0 | 3 |
| BEST4 | SCARA5 | 0.726498 | 4 | 0 | 3 |
| BEST4 | BSX | 0.725433 | 3 | 0 | 3 |
For details and further investigation, click here
