| Full name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p12.1 | ||
| Entrez ID: 6489 | HGNC ID: HGNC:10869 | Ensembl Gene: ENSG00000111728 | OMIM ID: 601123 |
| Drug and gene relationship at DGIdb | |||
Expression of ST8SIA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ST8SIA1 | 6489 | 210073_at | 0.1494 | 0.6623 | |
| GSE20347 | ST8SIA1 | 6489 | 210073_at | 0.3874 | 0.0915 | |
| GSE23400 | ST8SIA1 | 6489 | 210073_at | 0.0583 | 0.2002 | |
| GSE26886 | ST8SIA1 | 6489 | 210073_at | 1.5176 | 0.0001 | |
| GSE29001 | ST8SIA1 | 6489 | 210073_at | 0.8173 | 0.0181 | |
| GSE38129 | ST8SIA1 | 6489 | 210073_at | 0.2581 | 0.3583 | |
| GSE45670 | ST8SIA1 | 6489 | 210073_at | -0.2372 | 0.5372 | |
| GSE53622 | ST8SIA1 | 6489 | 40779 | 0.1990 | 0.0066 | |
| GSE53624 | ST8SIA1 | 6489 | 40779 | 0.0593 | 0.5840 | |
| GSE63941 | ST8SIA1 | 6489 | 210073_at | -3.7507 | 0.0000 | |
| GSE77861 | ST8SIA1 | 6489 | 210073_at | 0.1171 | 0.4874 | |
| GSE97050 | ST8SIA1 | 6489 | A_33_P3380751 | -0.1601 | 0.4710 | |
| SRP007169 | ST8SIA1 | 6489 | RNAseq | 0.4518 | 0.5981 | |
| SRP008496 | ST8SIA1 | 6489 | RNAseq | 0.1390 | 0.8897 | |
| SRP064894 | ST8SIA1 | 6489 | RNAseq | 0.0167 | 0.9480 | |
| SRP133303 | ST8SIA1 | 6489 | RNAseq | 0.0056 | 0.9797 | |
| SRP159526 | ST8SIA1 | 6489 | RNAseq | 0.7565 | 0.1252 | |
| SRP193095 | ST8SIA1 | 6489 | RNAseq | 0.5752 | 0.0012 | |
| SRP219564 | ST8SIA1 | 6489 | RNAseq | -0.1075 | 0.8722 | |
| TCGA | ST8SIA1 | 6489 | RNAseq | -0.0604 | 0.7809 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by ST8SIA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ST8SIA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ST8SIA1 | 6489 | 10 | 1 | 19 | |
| GSE20123 | ST8SIA1 | 6489 | 10 | 1 | 19 | |
| GSE43470 | ST8SIA1 | 6489 | 9 | 4 | 30 | |
| GSE46452 | ST8SIA1 | 6489 | 10 | 1 | 48 | |
| GSE47630 | ST8SIA1 | 6489 | 14 | 1 | 25 | |
| GSE54993 | ST8SIA1 | 6489 | 1 | 9 | 60 | |
| GSE54994 | ST8SIA1 | 6489 | 11 | 2 | 40 | |
| GSE60625 | ST8SIA1 | 6489 | 0 | 1 | 10 | |
| GSE74703 | ST8SIA1 | 6489 | 9 | 3 | 24 | |
| GSE74704 | ST8SIA1 | 6489 | 6 | 1 | 13 | |
| TCGA | ST8SIA1 | 6489 | 43 | 6 | 47 |
Total number of gains: 123; Total number of losses: 30; Total Number of normals: 335.
Somatic mutations of ST8SIA1:
Generating mutation plots.
Highly correlated genes for ST8SIA1:
Showing top 20/251 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ST8SIA1 | YY2 | 0.886501 | 3 | 0 | 3 |
| ST8SIA1 | OR2T27 | 0.863471 | 3 | 0 | 3 |
| ST8SIA1 | DCDC1 | 0.849175 | 3 | 0 | 3 |
| ST8SIA1 | RNF180 | 0.843408 | 3 | 0 | 3 |
| ST8SIA1 | OR2T1 | 0.832435 | 3 | 0 | 3 |
| ST8SIA1 | ZAN | 0.828306 | 3 | 0 | 3 |
| ST8SIA1 | MRGPRG | 0.827869 | 3 | 0 | 3 |
| ST8SIA1 | PSMB11 | 0.82134 | 3 | 0 | 3 |
| ST8SIA1 | FOXE3 | 0.815382 | 3 | 0 | 3 |
| ST8SIA1 | SLC22A12 | 0.814884 | 3 | 0 | 3 |
| ST8SIA1 | PRSS38 | 0.813086 | 3 | 0 | 3 |
| ST8SIA1 | PLA2G2C | 0.812606 | 3 | 0 | 3 |
| ST8SIA1 | BBC3 | 0.811575 | 3 | 0 | 3 |
| ST8SIA1 | FBRSL1 | 0.804334 | 4 | 0 | 4 |
| ST8SIA1 | TSSK3 | 0.804126 | 3 | 0 | 3 |
| ST8SIA1 | SHROOM4 | 0.802742 | 3 | 0 | 3 |
| ST8SIA1 | LBX2 | 0.799767 | 3 | 0 | 3 |
| ST8SIA1 | OR10AD1 | 0.79606 | 3 | 0 | 3 |
| ST8SIA1 | OTOG | 0.792715 | 3 | 0 | 3 |
| ST8SIA1 | FOXA3 | 0.792187 | 4 | 0 | 4 |
For details and further investigation, click here
