FXYD2

 

Full name: FXYD domain containing ion transport regulator 2 Alias Symbol: MGC12372
Type: protein-coding gene Cytoband: 11q23.3
Entrez ID: 486 HGNC ID: HGNC:4026 Ensembl Gene: ENSG00000137731 OMIM ID: 601814
Drug and gene relationship at DGIdb

 

FXYD2 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04919Thyroid hormone signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa04961Endocrine and other factor-regulated calcium reabsorption

 

Expression of FXYD2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FXYD2 486 205674_x_at -0.1730 0.3436
GSE20347 FXYD2 486 205674_x_at -0.1063 0.2107
GSE23400 FXYD2 486 205674_x_at -0.1045 0.0133
GSE26886 FXYD2 486 205674_x_at 0.4456 0.0004
GSE29001 FXYD2 486 205674_x_at -0.1046 0.5924
GSE38129 FXYD2 486 205674_x_at -0.2933 0.0076
GSE45670 FXYD2 486 205674_x_at -0.0816 0.4869
GSE53622 FXYD2 486 108896 -0.2622 0.0024
GSE53624 FXYD2 486 108896 -0.6982 0.0000
GSE63941 FXYD2 486 205674_x_at 0.2182 0.1237
GSE77861 FXYD2 486 205674_x_at 0.0184 0.9006
GSE97050 FXYD2 486 A_33_P3228445 -0.3225 0.1702
TCGA FXYD2 486 RNAseq 0.4352 0.4888

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by FXYD2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FXYD2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FXYD2 486 1 11 18
GSE20123 FXYD2 486 1 11 18
GSE43470 FXYD2 486 2 9 32
GSE46452 FXYD2 486 3 26 30
GSE47630 FXYD2 486 2 19 19
GSE54993 FXYD2 486 10 0 60
GSE54994 FXYD2 486 5 19 29
GSE60625 FXYD2 486 0 3 8
GSE74703 FXYD2 486 1 6 29
GSE74704 FXYD2 486 0 7 13
TCGA FXYD2 486 5 50 41

Total number of gains: 30; Total number of losses: 161; Total Number of normals: 297.  

 

Somatic mutations of FXYD2:

 

Generating mutation plots.

 

Highly correlated genes for FXYD2:

 

Showing top 20/673 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FXYD2ESPNL0.847607303
FXYD2KRTAP6-10.83841303
FXYD2GDF70.814865303
FXYD2TTC7A0.81398404
FXYD2SLC22A310.808928303
FXYD2SPN0.808751303
FXYD2YY20.808413303
FXYD2PRSS380.807442303
FXYD2BARHL20.80061303
FXYD2BTBD90.782994303
FXYD2MRGPRE0.779284303
FXYD2OR13G10.776911303
FXYD2BSND0.776377303
FXYD2TPRX10.773837303
FXYD2PRDM160.772667303
FXYD2CLEC18C0.769433303
FXYD2MFSD2B0.767826303
FXYD2ANKRD330.763296404
FXYD2SALL30.762854303
FXYD2OR2B110.755845303

For details and further investigation, click here