FZD5

 

Full name: frizzled class receptor 5 Alias Symbol: HFZ5|DKFZP434E2135
Type: protein-coding gene Cytoband: 2q33.3
Entrez ID: 7855 HGNC ID: HGNC:4043 Ensembl Gene: ENSG00000163251 OMIM ID: 601723
Drug and gene relationship at DGIdb
Screen Evidence:

 

FZD5 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05217Basal cell carcinoma

 

Expression of FZD5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FZD5 7855 221245_s_at -0.6422 0.4813
GSE20347 FZD5 7855 221245_s_at -0.1573 0.6037
GSE23400 FZD5 7855 206136_at -0.0167 0.6586
GSE26886 FZD5 7855 221245_s_at -0.4629 0.2337
GSE29001 FZD5 7855 221245_s_at -0.0942 0.8184
GSE38129 FZD5 7855 221245_s_at -0.3271 0.1350
GSE45670 FZD5 7855 221245_s_at 0.4522 0.0287
GSE53622 FZD5 7855 21605 -0.5447 0.0000
GSE53624 FZD5 7855 21605 -0.4495 0.0000
GSE63941 FZD5 7855 221245_s_at 2.7040 0.0005
GSE77861 FZD5 7855 221245_s_at 0.2729 0.0792
GSE97050 FZD5 7855 A_23_P108437 -0.2254 0.3403
SRP007169 FZD5 7855 RNAseq 1.3854 0.0485
SRP008496 FZD5 7855 RNAseq 0.7192 0.1535
SRP064894 FZD5 7855 RNAseq 0.2611 0.1145
SRP133303 FZD5 7855 RNAseq 0.2995 0.1911
SRP159526 FZD5 7855 RNAseq 0.0342 0.9271
SRP193095 FZD5 7855 RNAseq -0.3500 0.3401
SRP219564 FZD5 7855 RNAseq -0.3803 0.4477
TCGA FZD5 7855 RNAseq -0.5300 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by FZD5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FZD5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FZD5 7855 3 8 19
GSE20123 FZD5 7855 3 8 19
GSE43470 FZD5 7855 2 4 37
GSE46452 FZD5 7855 1 4 54
GSE47630 FZD5 7855 4 5 31
GSE54993 FZD5 7855 0 3 67
GSE54994 FZD5 7855 8 9 36
GSE60625 FZD5 7855 0 3 8
GSE74703 FZD5 7855 2 3 31
GSE74704 FZD5 7855 2 4 14
TCGA FZD5 7855 15 21 60

Total number of gains: 40; Total number of losses: 72; Total Number of normals: 376.  

 

Somatic mutations of FZD5:

 

Generating mutation plots.

 

Highly correlated genes for FZD5:

 

Showing all 13 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FZD5NET10.651629404
FZD5TRIM70.580425403
FZD5FAM199X0.577834303
FZD5SDHD0.561241403
FZD5COQ90.549794503
FZD5NDUFA100.535955504
FZD5BARD10.533975503
FZD5NDUFS10.533502604
FZD5PAFAH20.53265603
FZD5MRPL460.516057503
FZD5DLG50.509861403
FZD5SLC12A20.509604403
FZD5AAMP0.508249403

For details and further investigation, click here