| Full name: NADH:ubiquinone oxidoreductase core subunit S1 | Alias Symbol: CI-75k | ||
| Type: protein-coding gene | Cytoband: 2q33.3 | ||
| Entrez ID: 4719 | HGNC ID: HGNC:7707 | Ensembl Gene: ENSG00000023228 | OMIM ID: 157655 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NDUFS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NDUFS1 | 4719 | 203039_s_at | -0.4622 | 0.4425 | |
| GSE20347 | NDUFS1 | 4719 | 203039_s_at | -0.3488 | 0.0328 | |
| GSE23400 | NDUFS1 | 4719 | 203039_s_at | -0.1585 | 0.0870 | |
| GSE26886 | NDUFS1 | 4719 | 203039_s_at | -0.1633 | 0.4617 | |
| GSE29001 | NDUFS1 | 4719 | 203039_s_at | -0.4992 | 0.1795 | |
| GSE38129 | NDUFS1 | 4719 | 203039_s_at | -0.3048 | 0.0117 | |
| GSE45670 | NDUFS1 | 4719 | 203039_s_at | -0.1260 | 0.5073 | |
| GSE53622 | NDUFS1 | 4719 | 77063 | -0.6054 | 0.0000 | |
| GSE53624 | NDUFS1 | 4719 | 77063 | -0.4508 | 0.0000 | |
| GSE63941 | NDUFS1 | 4719 | 203039_s_at | -0.1030 | 0.7553 | |
| GSE77861 | NDUFS1 | 4719 | 203039_s_at | -0.1398 | 0.4450 | |
| GSE97050 | NDUFS1 | 4719 | A_23_P131365 | -0.3326 | 0.3408 | |
| SRP007169 | NDUFS1 | 4719 | RNAseq | 0.1443 | 0.7760 | |
| SRP008496 | NDUFS1 | 4719 | RNAseq | 0.0858 | 0.7689 | |
| SRP064894 | NDUFS1 | 4719 | RNAseq | -0.5450 | 0.0090 | |
| SRP133303 | NDUFS1 | 4719 | RNAseq | -0.3123 | 0.0010 | |
| SRP159526 | NDUFS1 | 4719 | RNAseq | -0.2610 | 0.3940 | |
| SRP193095 | NDUFS1 | 4719 | RNAseq | -0.5886 | 0.0000 | |
| SRP219564 | NDUFS1 | 4719 | RNAseq | -0.6231 | 0.0375 | |
| TCGA | NDUFS1 | 4719 | RNAseq | -0.2600 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NDUFS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NDUFS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NDUFS1 | 4719 | 3 | 6 | 21 | |
| GSE20123 | NDUFS1 | 4719 | 3 | 6 | 21 | |
| GSE43470 | NDUFS1 | 4719 | 1 | 4 | 38 | |
| GSE46452 | NDUFS1 | 4719 | 1 | 4 | 54 | |
| GSE47630 | NDUFS1 | 4719 | 4 | 5 | 31 | |
| GSE54993 | NDUFS1 | 4719 | 0 | 3 | 67 | |
| GSE54994 | NDUFS1 | 4719 | 8 | 9 | 36 | |
| GSE60625 | NDUFS1 | 4719 | 0 | 3 | 8 | |
| GSE74703 | NDUFS1 | 4719 | 1 | 3 | 32 | |
| GSE74704 | NDUFS1 | 4719 | 2 | 2 | 16 | |
| TCGA | NDUFS1 | 4719 | 14 | 21 | 61 |
Total number of gains: 37; Total number of losses: 66; Total Number of normals: 385.
Somatic mutations of NDUFS1:
Generating mutation plots.
Highly correlated genes for NDUFS1:
Showing top 20/834 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NDUFS1 | CMTM6 | 0.817315 | 3 | 0 | 3 |
| NDUFS1 | EIF3I | 0.805088 | 3 | 0 | 3 |
| NDUFS1 | TAF7 | 0.773737 | 3 | 0 | 3 |
| NDUFS1 | RSRC2 | 0.750948 | 3 | 0 | 3 |
| NDUFS1 | VDAC3 | 0.749255 | 3 | 0 | 3 |
| NDUFS1 | BDP1 | 0.747262 | 3 | 0 | 3 |
| NDUFS1 | PPP1R3B | 0.74042 | 3 | 0 | 3 |
| NDUFS1 | PSMD1 | 0.740234 | 3 | 0 | 3 |
| NDUFS1 | THUMPD3 | 0.740192 | 3 | 0 | 3 |
| NDUFS1 | KIAA1191 | 0.739599 | 3 | 0 | 3 |
| NDUFS1 | HDAC3 | 0.738337 | 3 | 0 | 3 |
| NDUFS1 | SUGT1 | 0.728818 | 3 | 0 | 3 |
| NDUFS1 | DCP1A | 0.728509 | 3 | 0 | 3 |
| NDUFS1 | PIK3C3 | 0.727606 | 5 | 0 | 5 |
| NDUFS1 | TMEM186 | 0.723639 | 3 | 0 | 3 |
| NDUFS1 | MAPK9 | 0.71817 | 3 | 0 | 3 |
| NDUFS1 | SRXN1 | 0.71642 | 3 | 0 | 3 |
| NDUFS1 | PSMD7 | 0.716238 | 4 | 0 | 4 |
| NDUFS1 | LARP7 | 0.715511 | 3 | 0 | 3 |
| NDUFS1 | RSL24D1 | 0.715476 | 3 | 0 | 3 |
For details and further investigation, click here
