| Full name: BRCA1 associated RING domain 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 580 | HGNC ID: HGNC:952 | Ensembl Gene: ENSG00000138376 | OMIM ID: 601593 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of BARD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BARD1 | 580 | 205345_at | -0.1312 | 0.8078 | |
| GSE20347 | BARD1 | 580 | 205345_at | -0.3824 | 0.1085 | |
| GSE23400 | BARD1 | 580 | 205345_at | -0.1138 | 0.2866 | |
| GSE26886 | BARD1 | 580 | 205345_at | -0.9032 | 0.0000 | |
| GSE29001 | BARD1 | 580 | 205345_at | -0.4117 | 0.3266 | |
| GSE38129 | BARD1 | 580 | 205345_at | -0.0879 | 0.7939 | |
| GSE45670 | BARD1 | 580 | 227545_at | -0.3062 | 0.0931 | |
| GSE53622 | BARD1 | 580 | 1655 | -0.2158 | 0.0211 | |
| GSE53624 | BARD1 | 580 | 1655 | -0.3015 | 0.0000 | |
| GSE63941 | BARD1 | 580 | 205345_at | 2.2223 | 0.0002 | |
| GSE77861 | BARD1 | 580 | 205345_at | 0.1999 | 0.4251 | |
| GSE97050 | BARD1 | 580 | A_23_P67771 | -0.0254 | 0.9419 | |
| SRP007169 | BARD1 | 580 | RNAseq | -0.2612 | 0.5457 | |
| SRP008496 | BARD1 | 580 | RNAseq | -0.0831 | 0.7898 | |
| SRP064894 | BARD1 | 580 | RNAseq | -0.7298 | 0.0046 | |
| SRP133303 | BARD1 | 580 | RNAseq | -0.1014 | 0.7054 | |
| SRP159526 | BARD1 | 580 | RNAseq | -0.2885 | 0.5286 | |
| SRP193095 | BARD1 | 580 | RNAseq | -0.4078 | 0.0134 | |
| SRP219564 | BARD1 | 580 | RNAseq | -0.4231 | 0.3573 | |
| TCGA | BARD1 | 580 | RNAseq | 0.2856 | 0.0068 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by BARD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BARD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BARD1 | 580 | 1 | 13 | 16 | |
| GSE20123 | BARD1 | 580 | 1 | 13 | 16 | |
| GSE43470 | BARD1 | 580 | 1 | 6 | 36 | |
| GSE46452 | BARD1 | 580 | 0 | 5 | 54 | |
| GSE47630 | BARD1 | 580 | 4 | 5 | 31 | |
| GSE54993 | BARD1 | 580 | 0 | 3 | 67 | |
| GSE54994 | BARD1 | 580 | 8 | 9 | 36 | |
| GSE60625 | BARD1 | 580 | 0 | 3 | 8 | |
| GSE74703 | BARD1 | 580 | 1 | 5 | 30 | |
| GSE74704 | BARD1 | 580 | 1 | 7 | 12 | |
| TCGA | BARD1 | 580 | 12 | 27 | 57 |
Total number of gains: 29; Total number of losses: 96; Total Number of normals: 363.
Somatic mutations of BARD1:
Generating mutation plots.
Highly correlated genes for BARD1:
Showing top 20/380 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BARD1 | FRMD6 | 0.813829 | 3 | 0 | 3 |
| BARD1 | ANLN | 0.788426 | 3 | 0 | 3 |
| BARD1 | RFC3 | 0.784997 | 3 | 0 | 3 |
| BARD1 | RHBDD1 | 0.767825 | 3 | 0 | 3 |
| BARD1 | PRPF38A | 0.760296 | 4 | 0 | 4 |
| BARD1 | KIF15 | 0.756809 | 3 | 0 | 3 |
| BARD1 | SPIN4 | 0.751162 | 3 | 0 | 3 |
| BARD1 | RPL27A | 0.747509 | 3 | 0 | 3 |
| BARD1 | ECD | 0.742214 | 3 | 0 | 3 |
| BARD1 | TMEM126A | 0.738638 | 3 | 0 | 3 |
| BARD1 | MPP5 | 0.733119 | 4 | 0 | 4 |
| BARD1 | CUL4B | 0.730671 | 3 | 0 | 3 |
| BARD1 | TRAPPC6B | 0.730152 | 4 | 0 | 3 |
| BARD1 | PANK1 | 0.728181 | 3 | 0 | 3 |
| BARD1 | ARID2 | 0.722949 | 3 | 0 | 3 |
| BARD1 | DNAJA2 | 0.71789 | 3 | 0 | 3 |
| BARD1 | PRC1 | 0.715748 | 3 | 0 | 3 |
| BARD1 | ACSL3 | 0.713416 | 4 | 0 | 4 |
| BARD1 | CHD8 | 0.712712 | 3 | 0 | 3 |
| BARD1 | SYNE2 | 0.711777 | 4 | 0 | 4 |
For details and further investigation, click here
