| Full name: succinate dehydrogenase complex subunit D | Alias Symbol: cybS | ||
| Type: protein-coding gene | Cytoband: 11q23.1 | ||
| Entrez ID: 6392 | HGNC ID: HGNC:10683 | Ensembl Gene: ENSG00000204370 | OMIM ID: 602690 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SDHD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SDHD | 6392 | 202026_at | -0.5297 | 0.0736 | |
| GSE20347 | SDHD | 6392 | 202026_at | -0.6057 | 0.0004 | |
| GSE23400 | SDHD | 6392 | 202026_at | -0.4021 | 0.0000 | |
| GSE26886 | SDHD | 6392 | 202026_at | -1.1206 | 0.0000 | |
| GSE29001 | SDHD | 6392 | 202026_at | -0.8048 | 0.1318 | |
| GSE38129 | SDHD | 6392 | 202026_at | -0.5842 | 0.0000 | |
| GSE45670 | SDHD | 6392 | 202026_at | -0.3993 | 0.0337 | |
| GSE53622 | SDHD | 6392 | 149934 | -0.4945 | 0.0000 | |
| GSE53624 | SDHD | 6392 | 149934 | -0.6894 | 0.0000 | |
| GSE63941 | SDHD | 6392 | 202026_at | 0.3844 | 0.3065 | |
| GSE77861 | SDHD | 6392 | 202026_at | -0.5583 | 0.2309 | |
| GSE97050 | SDHD | 6392 | A_23_P138967 | -0.3987 | 0.1608 | |
| SRP007169 | SDHD | 6392 | RNAseq | -1.2484 | 0.0001 | |
| SRP008496 | SDHD | 6392 | RNAseq | -1.1887 | 0.0000 | |
| SRP064894 | SDHD | 6392 | RNAseq | -1.0298 | 0.0000 | |
| SRP133303 | SDHD | 6392 | RNAseq | -0.5908 | 0.0001 | |
| SRP159526 | SDHD | 6392 | RNAseq | -0.4904 | 0.2633 | |
| SRP193095 | SDHD | 6392 | RNAseq | -1.3310 | 0.0000 | |
| SRP219564 | SDHD | 6392 | RNAseq | -1.0263 | 0.0001 | |
| TCGA | SDHD | 6392 | RNAseq | -0.1400 | 0.0068 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by SDHD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SDHD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SDHD | 6392 | 0 | 12 | 18 | |
| GSE20123 | SDHD | 6392 | 0 | 12 | 18 | |
| GSE43470 | SDHD | 6392 | 2 | 6 | 35 | |
| GSE46452 | SDHD | 6392 | 3 | 26 | 30 | |
| GSE47630 | SDHD | 6392 | 2 | 19 | 19 | |
| GSE54993 | SDHD | 6392 | 10 | 0 | 60 | |
| GSE54994 | SDHD | 6392 | 5 | 19 | 29 | |
| GSE60625 | SDHD | 6392 | 0 | 3 | 8 | |
| GSE74703 | SDHD | 6392 | 1 | 4 | 31 | |
| GSE74704 | SDHD | 6392 | 0 | 8 | 12 | |
| TCGA | SDHD | 6392 | 7 | 48 | 41 |
Total number of gains: 30; Total number of losses: 157; Total Number of normals: 301.
Somatic mutations of SDHD:
Generating mutation plots.
Highly correlated genes for SDHD:
Showing top 20/1183 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SDHD | COPS2 | 0.794967 | 4 | 0 | 4 |
| SDHD | SLTM | 0.750248 | 3 | 0 | 3 |
| SDHD | CUL1 | 0.749457 | 3 | 0 | 3 |
| SDHD | KIF1B | 0.743694 | 3 | 0 | 3 |
| SDHD | CAPNS2 | 0.732879 | 4 | 0 | 4 |
| SDHD | MTMR9 | 0.731987 | 3 | 0 | 3 |
| SDHD | MAT2B | 0.717208 | 4 | 0 | 4 |
| SDHD | DDX1 | 0.712305 | 5 | 0 | 5 |
| SDHD | SSBP1 | 0.711213 | 4 | 0 | 4 |
| SDHD | ANG | 0.698146 | 3 | 0 | 3 |
| SDHD | REXO2 | 0.691095 | 12 | 0 | 11 |
| SDHD | DCTN4 | 0.686164 | 4 | 0 | 3 |
| SDHD | DOCK8 | 0.686108 | 3 | 0 | 3 |
| SDHD | AZI2 | 0.684927 | 8 | 0 | 6 |
| SDHD | MRPS33 | 0.67994 | 3 | 0 | 3 |
| SDHD | TIFA | 0.679061 | 5 | 0 | 5 |
| SDHD | RWDD2B | 0.677617 | 4 | 0 | 3 |
| SDHD | DLAT | 0.674695 | 13 | 0 | 12 |
| SDHD | CERS3 | 0.673871 | 4 | 0 | 4 |
| SDHD | COBLL1 | 0.66954 | 11 | 0 | 9 |
For details and further investigation, click here
