| Full name: GRB2 associated binding protein family member 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q11.1 | ||
| Entrez ID: 128954 | HGNC ID: HGNC:18325 | Ensembl Gene: ENSG00000215568 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of GAB4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GAB4 | 128954 | 1563816_at | 0.0164 | 0.9676 | |
| GSE26886 | GAB4 | 128954 | 1563816_at | -0.2450 | 0.1352 | |
| GSE45670 | GAB4 | 128954 | 1563816_at | -0.0198 | 0.8615 | |
| GSE63941 | GAB4 | 128954 | 1563816_at | 0.4626 | 0.0039 | |
| GSE77861 | GAB4 | 128954 | 1563816_at | -0.2066 | 0.0842 | |
| TCGA | GAB4 | 128954 | RNAseq | 1.0842 | 0.6347 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GAB4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GAB4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GAB4 | 128954 | 4 | 7 | 19 | |
| GSE20123 | GAB4 | 128954 | 4 | 7 | 19 | |
| GSE43470 | GAB4 | 128954 | 4 | 8 | 31 | |
| GSE46452 | GAB4 | 128954 | 32 | 2 | 25 | |
| GSE47630 | GAB4 | 128954 | 8 | 5 | 27 | |
| GSE54993 | GAB4 | 128954 | 2 | 7 | 61 | |
| GSE54994 | GAB4 | 128954 | 11 | 7 | 35 | |
| GSE60625 | GAB4 | 128954 | 5 | 0 | 6 | |
| GSE74703 | GAB4 | 128954 | 4 | 6 | 26 | |
| GSE74704 | GAB4 | 128954 | 2 | 4 | 14 | |
| TCGA | GAB4 | 128954 | 25 | 17 | 54 |
Total number of gains: 101; Total number of losses: 70; Total Number of normals: 317.
Somatic mutations of GAB4:
Generating mutation plots.
Highly correlated genes for GAB4:
Showing top 20/81 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GAB4 | SPRR4 | 0.707677 | 3 | 0 | 3 |
| GAB4 | PRB1 | 0.695671 | 3 | 0 | 3 |
| GAB4 | EPOR | 0.681969 | 3 | 0 | 3 |
| GAB4 | SPEF2 | 0.67902 | 3 | 0 | 3 |
| GAB4 | PCGEM1 | 0.677946 | 3 | 0 | 3 |
| GAB4 | E2F4 | 0.670799 | 4 | 0 | 3 |
| GAB4 | SPATA24 | 0.664553 | 4 | 0 | 4 |
| GAB4 | ART1 | 0.659481 | 3 | 0 | 3 |
| GAB4 | MESP1 | 0.649548 | 3 | 0 | 3 |
| GAB4 | LYPD8 | 0.648485 | 4 | 0 | 3 |
| GAB4 | TAAR8 | 0.639672 | 3 | 0 | 3 |
| GAB4 | AWAT1 | 0.639242 | 3 | 0 | 3 |
| GAB4 | CACNA1G | 0.636277 | 4 | 0 | 3 |
| GAB4 | C20orf203 | 0.632382 | 3 | 0 | 3 |
| GAB4 | C2orf72 | 0.627502 | 4 | 0 | 4 |
| GAB4 | LINC01270 | 0.619131 | 3 | 0 | 3 |
| GAB4 | PTPRG | 0.617676 | 3 | 0 | 3 |
| GAB4 | NFIA-AS2 | 0.617111 | 3 | 0 | 3 |
| GAB4 | KRT2 | 0.61523 | 3 | 0 | 3 |
| GAB4 | SLC22A14 | 0.606522 | 3 | 0 | 3 |
For details and further investigation, click here
