| Full name: sperm flagellar 2 | Alias Symbol: KPL2|FLJ23577|CT122 | ||
| Type: protein-coding gene | Cytoband: 5p13.2 | ||
| Entrez ID: 79925 | HGNC ID: HGNC:26293 | Ensembl Gene: ENSG00000152582 | OMIM ID: 610172 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SPEF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPEF2 | 79925 | 233429_at | -0.1196 | 0.5945 | |
| GSE26886 | SPEF2 | 79925 | 233429_at | -0.3037 | 0.0123 | |
| GSE45670 | SPEF2 | 79925 | 1552716_at | -0.1086 | 0.6229 | |
| GSE53622 | SPEF2 | 79925 | 40270 | -0.1581 | 0.3927 | |
| GSE53624 | SPEF2 | 79925 | 40270 | -0.3102 | 0.0529 | |
| GSE63941 | SPEF2 | 79925 | 1552716_at | 0.2995 | 0.7323 | |
| GSE77861 | SPEF2 | 79925 | 232745_x_at | -0.0967 | 0.2626 | |
| GSE97050 | SPEF2 | 79925 | A_23_P252388 | -0.1248 | 0.8948 | |
| SRP007169 | SPEF2 | 79925 | RNAseq | 1.8008 | 0.0742 | |
| SRP064894 | SPEF2 | 79925 | RNAseq | -0.2412 | 0.4847 | |
| SRP133303 | SPEF2 | 79925 | RNAseq | -0.2980 | 0.0524 | |
| SRP159526 | SPEF2 | 79925 | RNAseq | 1.0937 | 0.0173 | |
| SRP193095 | SPEF2 | 79925 | RNAseq | -0.0733 | 0.7816 | |
| SRP219564 | SPEF2 | 79925 | RNAseq | -0.4398 | 0.3455 | |
| TCGA | SPEF2 | 79925 | RNAseq | -0.5929 | 0.0335 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SPEF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPEF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPEF2 | 79925 | 10 | 0 | 20 | |
| GSE20123 | SPEF2 | 79925 | 10 | 0 | 20 | |
| GSE43470 | SPEF2 | 79925 | 17 | 0 | 26 | |
| GSE46452 | SPEF2 | 79925 | 6 | 21 | 32 | |
| GSE47630 | SPEF2 | 79925 | 6 | 12 | 22 | |
| GSE54993 | SPEF2 | 79925 | 5 | 4 | 61 | |
| GSE54994 | SPEF2 | 79925 | 26 | 2 | 25 | |
| GSE60625 | SPEF2 | 79925 | 0 | 0 | 11 | |
| GSE74703 | SPEF2 | 79925 | 13 | 0 | 23 | |
| GSE74704 | SPEF2 | 79925 | 9 | 0 | 11 | |
| TCGA | SPEF2 | 79925 | 52 | 6 | 38 |
Total number of gains: 154; Total number of losses: 45; Total Number of normals: 289.
Somatic mutations of SPEF2:
Generating mutation plots.
Highly correlated genes for SPEF2:
Showing top 20/105 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPEF2 | OR4D2 | 0.781911 | 3 | 0 | 3 |
| SPEF2 | CHRNA2 | 0.764831 | 3 | 0 | 3 |
| SPEF2 | CD300LG | 0.759885 | 3 | 0 | 3 |
| SPEF2 | OR12D3 | 0.757731 | 3 | 0 | 3 |
| SPEF2 | CDH22 | 0.753779 | 3 | 0 | 3 |
| SPEF2 | SLC22A8 | 0.745814 | 3 | 0 | 3 |
| SPEF2 | MYOZ3 | 0.723484 | 3 | 0 | 3 |
| SPEF2 | DNAI1 | 0.714831 | 3 | 0 | 3 |
| SPEF2 | KRT2 | 0.714151 | 3 | 0 | 3 |
| SPEF2 | CD300LB | 0.711622 | 3 | 0 | 3 |
| SPEF2 | XIRP1 | 0.708256 | 3 | 0 | 3 |
| SPEF2 | CCL25 | 0.69795 | 3 | 0 | 3 |
| SPEF2 | PRAMEF12 | 0.694006 | 3 | 0 | 3 |
| SPEF2 | C11orf21 | 0.693995 | 3 | 0 | 3 |
| SPEF2 | LACRT | 0.693242 | 3 | 0 | 3 |
| SPEF2 | C2orf72 | 0.692254 | 3 | 0 | 3 |
| SPEF2 | SRCIN1 | 0.691894 | 3 | 0 | 3 |
| SPEF2 | SP7 | 0.688681 | 3 | 0 | 3 |
| SPEF2 | KRTAP4-8 | 0.679182 | 3 | 0 | 3 |
| SPEF2 | INSL3 | 0.679154 | 3 | 0 | 3 |
For details and further investigation, click here
