| Full name: gamma-aminobutyric acid type A receptor gamma3 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q12 | ||
| Entrez ID: 2567 | HGNC ID: HGNC:4088 | Ensembl Gene: ENSG00000182256 | OMIM ID: 600233 |
| Drug and gene relationship at DGIdb | |||
GABRG3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa05032 | Morphine addiction |
Expression of GABRG3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRG3 | 2567 | 216895_at | 0.0992 | 0.7433 | |
| GSE20347 | GABRG3 | 2567 | 216895_at | -0.0225 | 0.8206 | |
| GSE23400 | GABRG3 | 2567 | 216895_at | -0.0894 | 0.0027 | |
| GSE26886 | GABRG3 | 2567 | 216895_at | 0.5111 | 0.0946 | |
| GSE29001 | GABRG3 | 2567 | 216895_at | -0.1117 | 0.3599 | |
| GSE38129 | GABRG3 | 2567 | 216895_at | -0.0038 | 0.9682 | |
| GSE45670 | GABRG3 | 2567 | 216895_at | 0.2398 | 0.0261 | |
| GSE53622 | GABRG3 | 2567 | 163457 | 0.5846 | 0.0007 | |
| GSE53624 | GABRG3 | 2567 | 163457 | 0.3533 | 0.0049 | |
| GSE63941 | GABRG3 | 2567 | 216895_at | 0.0859 | 0.7943 | |
| GSE77861 | GABRG3 | 2567 | 216895_at | 0.1043 | 0.6002 | |
| GSE97050 | GABRG3 | 2567 | A_33_P3210805 | -0.1309 | 0.6703 | |
| SRP133303 | GABRG3 | 2567 | RNAseq | 0.3807 | 0.0357 | |
| SRP159526 | GABRG3 | 2567 | RNAseq | 5.2850 | 0.0000 | |
| SRP193095 | GABRG3 | 2567 | RNAseq | 0.3745 | 0.1838 | |
| TCGA | GABRG3 | 2567 | RNAseq | 3.0306 | 0.0142 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by GABRG3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GABRG3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRG3 | 2567 | 3 | 8 | 19 | |
| GSE20123 | GABRG3 | 2567 | 3 | 8 | 19 | |
| GSE43470 | GABRG3 | 2567 | 3 | 5 | 35 | |
| GSE46452 | GABRG3 | 2567 | 3 | 7 | 49 | |
| GSE47630 | GABRG3 | 2567 | 8 | 11 | 21 | |
| GSE54993 | GABRG3 | 2567 | 4 | 6 | 60 | |
| GSE54994 | GABRG3 | 2567 | 7 | 6 | 40 | |
| GSE60625 | GABRG3 | 2567 | 4 | 3 | 4 | |
| GSE74703 | GABRG3 | 2567 | 3 | 3 | 30 | |
| GSE74704 | GABRG3 | 2567 | 2 | 5 | 13 | |
| TCGA | GABRG3 | 2567 | 16 | 17 | 63 |
Total number of gains: 56; Total number of losses: 79; Total Number of normals: 353.
Somatic mutations of GABRG3:
Generating mutation plots.
Highly correlated genes for GABRG3:
Showing top 20/151 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRG3 | BMP15 | 0.683808 | 3 | 0 | 3 |
| GABRG3 | SPX | 0.664374 | 3 | 0 | 3 |
| GABRG3 | KRTAP9-9 | 0.660049 | 3 | 0 | 3 |
| GABRG3 | GJA8 | 0.657678 | 3 | 0 | 3 |
| GABRG3 | RHAG | 0.653472 | 3 | 0 | 3 |
| GABRG3 | PLA2G2E | 0.6501 | 3 | 0 | 3 |
| GABRG3 | RAB3B | 0.644296 | 6 | 0 | 4 |
| GABRG3 | FBN2 | 0.637462 | 4 | 0 | 3 |
| GABRG3 | KRTAP19-1 | 0.637445 | 6 | 0 | 5 |
| GABRG3 | IL13 | 0.635316 | 3 | 0 | 3 |
| GABRG3 | MLXIPL | 0.63334 | 3 | 0 | 3 |
| GABRG3 | CRYGB | 0.633128 | 3 | 0 | 3 |
| GABRG3 | FABP7 | 0.631683 | 5 | 0 | 4 |
| GABRG3 | TUBB1 | 0.630792 | 4 | 0 | 4 |
| GABRG3 | PRB1 | 0.628021 | 3 | 0 | 3 |
| GABRG3 | CYP11B2 | 0.626255 | 3 | 0 | 3 |
| GABRG3 | OR10C1 | 0.625086 | 4 | 0 | 4 |
| GABRG3 | OR2J2 | 0.624538 | 4 | 0 | 4 |
| GABRG3 | MYOG | 0.623699 | 3 | 0 | 3 |
| GABRG3 | C11orf16 | 0.623154 | 3 | 0 | 3 |
For details and further investigation, click here
