| Full name: fibrillin 2 | Alias Symbol: DA9 | ||
| Type: protein-coding gene | Cytoband: 5q23.3 | ||
| Entrez ID: 2201 | HGNC ID: HGNC:3604 | Ensembl Gene: ENSG00000138829 | OMIM ID: 612570 |
| Drug and gene relationship at DGIdb | |||
Expression of FBN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBN2 | 2201 | 203184_at | 1.9057 | 0.3191 | |
| GSE20347 | FBN2 | 2201 | 203184_at | 1.4431 | 0.0147 | |
| GSE23400 | FBN2 | 2201 | 203184_at | 1.0800 | 0.0000 | |
| GSE26886 | FBN2 | 2201 | 203184_at | 3.0895 | 0.0009 | |
| GSE29001 | FBN2 | 2201 | 203184_at | 1.3254 | 0.0665 | |
| GSE38129 | FBN2 | 2201 | 203184_at | 1.4375 | 0.0055 | |
| GSE45670 | FBN2 | 2201 | 203184_at | 2.3832 | 0.0350 | |
| GSE53622 | FBN2 | 2201 | 30923 | 1.7113 | 0.0000 | |
| GSE53624 | FBN2 | 2201 | 30923 | 1.9498 | 0.0000 | |
| GSE63941 | FBN2 | 2201 | 203184_at | -5.6654 | 0.0071 | |
| GSE77861 | FBN2 | 2201 | 203184_at | 2.3882 | 0.0537 | |
| SRP007169 | FBN2 | 2201 | RNAseq | 7.1769 | 0.0001 | |
| SRP133303 | FBN2 | 2201 | RNAseq | 2.5151 | 0.0000 | |
| SRP193095 | FBN2 | 2201 | RNAseq | 1.7200 | 0.0001 | |
| SRP219564 | FBN2 | 2201 | RNAseq | 0.8503 | 0.4712 | |
| TCGA | FBN2 | 2201 | RNAseq | 0.6368 | 0.0364 |
Upregulated datasets: 10; Downregulated datasets: 1.
Survival by FBN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBN2 | 2201 | 1 | 12 | 17 | |
| GSE20123 | FBN2 | 2201 | 1 | 12 | 17 | |
| GSE43470 | FBN2 | 2201 | 3 | 8 | 32 | |
| GSE46452 | FBN2 | 2201 | 0 | 27 | 32 | |
| GSE47630 | FBN2 | 2201 | 0 | 21 | 19 | |
| GSE54993 | FBN2 | 2201 | 9 | 1 | 60 | |
| GSE54994 | FBN2 | 2201 | 2 | 14 | 37 | |
| GSE60625 | FBN2 | 2201 | 0 | 0 | 11 | |
| GSE74703 | FBN2 | 2201 | 2 | 6 | 28 | |
| GSE74704 | FBN2 | 2201 | 1 | 6 | 13 | |
| TCGA | FBN2 | 2201 | 2 | 40 | 54 |
Total number of gains: 21; Total number of losses: 147; Total Number of normals: 320.
Somatic mutations of FBN2:
Generating mutation plots.
Highly correlated genes for FBN2:
Showing top 20/378 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBN2 | PRSS35 | 0.690628 | 3 | 0 | 3 |
| FBN2 | ZIC5 | 0.669888 | 3 | 0 | 3 |
| FBN2 | DGKD | 0.666778 | 3 | 0 | 3 |
| FBN2 | FREM2 | 0.664625 | 6 | 0 | 4 |
| FBN2 | HES6 | 0.658641 | 3 | 0 | 3 |
| FBN2 | GABRG3 | 0.637462 | 4 | 0 | 3 |
| FBN2 | SCN9A | 0.636788 | 11 | 0 | 11 |
| FBN2 | EML1 | 0.631337 | 3 | 0 | 3 |
| FBN2 | C2orf69 | 0.622944 | 3 | 0 | 3 |
| FBN2 | AKAP8 | 0.618697 | 3 | 0 | 3 |
| FBN2 | CABYR | 0.61829 | 8 | 0 | 7 |
| FBN2 | CCDC51 | 0.613275 | 4 | 0 | 3 |
| FBN2 | SOX2-OT | 0.61267 | 6 | 0 | 5 |
| FBN2 | CHST7 | 0.611291 | 10 | 0 | 7 |
| FBN2 | TRPC1 | 0.609427 | 3 | 0 | 3 |
| FBN2 | HEY1 | 0.609091 | 9 | 0 | 7 |
| FBN2 | TRIM35 | 0.608968 | 4 | 0 | 3 |
| FBN2 | ODC1 | 0.604677 | 12 | 0 | 10 |
| FBN2 | PRKRA | 0.603737 | 5 | 0 | 4 |
| FBN2 | FERMT2 | 0.60034 | 3 | 0 | 3 |
For details and further investigation, click here
