| Full name: gap junction protein alpha 8 | Alias Symbol: CX50 | ||
| Type: protein-coding gene | Cytoband: 1q21.2 | ||
| Entrez ID: 2703 | HGNC ID: HGNC:4281 | Ensembl Gene: ENSG00000121634 | OMIM ID: 600897 |
| Drug and gene relationship at DGIdb | |||
Expression of GJA8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GJA8 | 2703 | 208489_at | -0.0338 | 0.9234 | |
| GSE20347 | GJA8 | 2703 | 208489_at | -0.0210 | 0.8355 | |
| GSE23400 | GJA8 | 2703 | 208489_at | -0.1213 | 0.0030 | |
| GSE26886 | GJA8 | 2703 | 208489_at | 0.1590 | 0.2371 | |
| GSE29001 | GJA8 | 2703 | 208489_at | -0.2591 | 0.0282 | |
| GSE38129 | GJA8 | 2703 | 208489_at | -0.0978 | 0.3909 | |
| GSE45670 | GJA8 | 2703 | 208489_at | -0.0813 | 0.4980 | |
| GSE63941 | GJA8 | 2703 | 208489_at | 0.4293 | 0.0167 | |
| GSE77861 | GJA8 | 2703 | 208489_at | -0.0957 | 0.3582 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GJA8 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GJA8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GJA8 | 2703 | 12 | 0 | 18 | |
| GSE20123 | GJA8 | 2703 | 12 | 0 | 18 | |
| GSE43470 | GJA8 | 2703 | 5 | 1 | 37 | |
| GSE46452 | GJA8 | 2703 | 2 | 1 | 56 | |
| GSE47630 | GJA8 | 2703 | 12 | 2 | 26 | |
| GSE54993 | GJA8 | 2703 | 0 | 2 | 68 | |
| GSE54994 | GJA8 | 2703 | 15 | 0 | 38 | |
| GSE60625 | GJA8 | 2703 | 0 | 0 | 11 | |
| GSE74703 | GJA8 | 2703 | 5 | 1 | 30 | |
| GSE74704 | GJA8 | 2703 | 6 | 0 | 14 | |
| TCGA | GJA8 | 2703 | 33 | 15 | 48 |
Total number of gains: 102; Total number of losses: 22; Total Number of normals: 364.
Somatic mutations of GJA8:
Generating mutation plots.
Highly correlated genes for GJA8:
Showing top 20/1325 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GJA8 | MTTP | 0.713325 | 3 | 0 | 3 |
| GJA8 | RAI1 | 0.71277 | 4 | 0 | 4 |
| GJA8 | GPR182 | 0.709207 | 5 | 0 | 5 |
| GJA8 | KRTAP5-8 | 0.701277 | 5 | 0 | 5 |
| GJA8 | ACRV1 | 0.700083 | 5 | 0 | 5 |
| GJA8 | CHRNA2 | 0.696145 | 6 | 0 | 6 |
| GJA8 | EPOR | 0.68976 | 7 | 0 | 6 |
| GJA8 | NPTXR | 0.689744 | 6 | 0 | 5 |
| GJA8 | TGIF2LY | 0.68837 | 3 | 0 | 3 |
| GJA8 | GLP1R | 0.684068 | 8 | 0 | 7 |
| GJA8 | FAM171A2 | 0.683136 | 5 | 0 | 5 |
| GJA8 | PAPPA2 | 0.682008 | 6 | 0 | 5 |
| GJA8 | EDA2R | 0.681324 | 5 | 0 | 5 |
| GJA8 | OR2H2 | 0.676971 | 7 | 0 | 7 |
| GJA8 | CER1 | 0.676498 | 7 | 0 | 6 |
| GJA8 | SLC22A14 | 0.675918 | 6 | 0 | 6 |
| GJA8 | LINC01015 | 0.674351 | 4 | 0 | 3 |
| GJA8 | CYP4A11 | 0.674097 | 5 | 0 | 5 |
| GJA8 | FAM222A-AS1 | 0.673575 | 3 | 0 | 3 |
| GJA8 | SPINT3 | 0.672793 | 6 | 0 | 6 |
For details and further investigation, click here
