| Full name: MLX interacting protein like | Alias Symbol: WS-bHLH|MIO|CHREBP|MONDOB|bHLHd14 | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 51085 | HGNC ID: HGNC:12744 | Ensembl Gene: ENSG00000009950 | OMIM ID: 605678 |
| Drug and gene relationship at DGIdb | |||
MLXIPL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04931 | Insulin resistance | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) |
Expression of MLXIPL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MLXIPL | 51085 | 221163_s_at | 0.0204 | 0.9522 | |
| GSE20347 | MLXIPL | 51085 | 221163_s_at | -0.0407 | 0.7203 | |
| GSE23400 | MLXIPL | 51085 | 221163_s_at | -0.1669 | 0.0011 | |
| GSE26886 | MLXIPL | 51085 | 221163_s_at | 0.3583 | 0.0084 | |
| GSE29001 | MLXIPL | 51085 | 221163_s_at | -0.1735 | 0.4127 | |
| GSE38129 | MLXIPL | 51085 | 221163_s_at | -0.1454 | 0.2327 | |
| GSE45670 | MLXIPL | 51085 | 221163_s_at | -0.1183 | 0.3272 | |
| GSE53622 | MLXIPL | 51085 | 8589 | 0.3040 | 0.0000 | |
| GSE53624 | MLXIPL | 51085 | 8589 | 0.3572 | 0.0001 | |
| GSE63941 | MLXIPL | 51085 | 221163_s_at | 0.5723 | 0.0100 | |
| GSE77861 | MLXIPL | 51085 | 221163_s_at | -0.0946 | 0.7178 | |
| SRP064894 | MLXIPL | 51085 | RNAseq | 0.2266 | 0.6356 | |
| SRP133303 | MLXIPL | 51085 | RNAseq | 0.9126 | 0.0717 | |
| SRP159526 | MLXIPL | 51085 | RNAseq | 2.1184 | 0.0013 | |
| SRP219564 | MLXIPL | 51085 | RNAseq | 2.2428 | 0.0003 | |
| TCGA | MLXIPL | 51085 | RNAseq | -0.1348 | 0.7262 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by MLXIPL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MLXIPL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MLXIPL | 51085 | 14 | 1 | 15 | |
| GSE20123 | MLXIPL | 51085 | 14 | 1 | 15 | |
| GSE43470 | MLXIPL | 51085 | 3 | 2 | 38 | |
| GSE46452 | MLXIPL | 51085 | 12 | 0 | 47 | |
| GSE47630 | MLXIPL | 51085 | 7 | 2 | 31 | |
| GSE54993 | MLXIPL | 51085 | 2 | 7 | 61 | |
| GSE54994 | MLXIPL | 51085 | 14 | 3 | 36 | |
| GSE60625 | MLXIPL | 51085 | 0 | 0 | 11 | |
| GSE74703 | MLXIPL | 51085 | 3 | 1 | 32 | |
| GSE74704 | MLXIPL | 51085 | 8 | 1 | 11 | |
| TCGA | MLXIPL | 51085 | 45 | 7 | 44 |
Total number of gains: 122; Total number of losses: 25; Total Number of normals: 341.
Somatic mutations of MLXIPL:
Generating mutation plots.
Highly correlated genes for MLXIPL:
Showing top 20/928 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MLXIPL | TTC9B | 0.812277 | 3 | 0 | 3 |
| MLXIPL | NAT2 | 0.7651 | 3 | 0 | 3 |
| MLXIPL | SHANK1 | 0.735218 | 3 | 0 | 3 |
| MLXIPL | TMEM151A | 0.720204 | 5 | 0 | 5 |
| MLXIPL | PERM1 | 0.718827 | 4 | 0 | 4 |
| MLXIPL | GRIN1 | 0.714152 | 6 | 0 | 6 |
| MLXIPL | CDK20 | 0.71259 | 3 | 0 | 3 |
| MLXIPL | RHAG | 0.707285 | 7 | 0 | 6 |
| MLXIPL | OR10H1 | 0.706589 | 3 | 0 | 3 |
| MLXIPL | CNIH2 | 0.705637 | 4 | 0 | 4 |
| MLXIPL | EDA2R | 0.700013 | 4 | 0 | 4 |
| MLXIPL | SLC4A1 | 0.697288 | 5 | 0 | 5 |
| MLXIPL | OR51E2 | 0.697162 | 3 | 0 | 3 |
| MLXIPL | HRH2 | 0.696 | 4 | 0 | 4 |
| MLXIPL | NRG1 | 0.693339 | 3 | 0 | 3 |
| MLXIPL | MGAT5B | 0.687249 | 3 | 0 | 3 |
| MLXIPL | KIR2DS3 | 0.686344 | 5 | 0 | 5 |
| MLXIPL | CNTN2 | 0.686007 | 4 | 0 | 4 |
| MLXIPL | AMN | 0.685461 | 7 | 0 | 6 |
| MLXIPL | ATF7 | 0.684799 | 4 | 0 | 4 |
For details and further investigation, click here
