| Full name: gamma-glutamyl carboxylase | Alias Symbol: VKCFD1 | ||
| Type: protein-coding gene | Cytoband: 2p11.2 | ||
| Entrez ID: 2677 | HGNC ID: HGNC:4247 | Ensembl Gene: ENSG00000115486 | OMIM ID: 137167 |
| Drug and gene relationship at DGIdb | |||
Expression of GGCX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GGCX | 2677 | 214005_at | 0.4360 | 0.2216 | |
| GSE20347 | GGCX | 2677 | 214005_at | 0.5666 | 0.0135 | |
| GSE23400 | GGCX | 2677 | 214006_s_at | 0.0923 | 0.0355 | |
| GSE26886 | GGCX | 2677 | 214005_at | 1.2419 | 0.0000 | |
| GSE29001 | GGCX | 2677 | 214005_at | 0.3047 | 0.2076 | |
| GSE38129 | GGCX | 2677 | 214005_at | 0.8639 | 0.0000 | |
| GSE45670 | GGCX | 2677 | 235413_at | 0.6575 | 0.0002 | |
| GSE53622 | GGCX | 2677 | 67564 | 0.3773 | 0.0000 | |
| GSE53624 | GGCX | 2677 | 67564 | 0.3770 | 0.0000 | |
| GSE63941 | GGCX | 2677 | 214005_at | 0.0970 | 0.8793 | |
| GSE77861 | GGCX | 2677 | 214006_s_at | 0.1955 | 0.1118 | |
| GSE97050 | GGCX | 2677 | A_32_P181103 | 0.5199 | 0.1836 | |
| SRP007169 | GGCX | 2677 | RNAseq | -0.0651 | 0.8723 | |
| SRP008496 | GGCX | 2677 | RNAseq | -0.5049 | 0.0220 | |
| SRP064894 | GGCX | 2677 | RNAseq | 0.4516 | 0.0236 | |
| SRP133303 | GGCX | 2677 | RNAseq | 0.5258 | 0.0000 | |
| SRP159526 | GGCX | 2677 | RNAseq | 0.6883 | 0.0235 | |
| SRP193095 | GGCX | 2677 | RNAseq | 0.1200 | 0.2268 | |
| SRP219564 | GGCX | 2677 | RNAseq | 0.2503 | 0.5430 | |
| TCGA | GGCX | 2677 | RNAseq | 0.0729 | 0.1783 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GGCX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GGCX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GGCX | 2677 | 9 | 2 | 19 | |
| GSE20123 | GGCX | 2677 | 9 | 2 | 19 | |
| GSE43470 | GGCX | 2677 | 6 | 2 | 35 | |
| GSE46452 | GGCX | 2677 | 2 | 3 | 54 | |
| GSE47630 | GGCX | 2677 | 7 | 0 | 33 | |
| GSE54993 | GGCX | 2677 | 0 | 6 | 64 | |
| GSE54994 | GGCX | 2677 | 10 | 0 | 43 | |
| GSE60625 | GGCX | 2677 | 0 | 3 | 8 | |
| GSE74703 | GGCX | 2677 | 5 | 1 | 30 | |
| GSE74704 | GGCX | 2677 | 7 | 0 | 13 | |
| TCGA | GGCX | 2677 | 35 | 3 | 58 |
Total number of gains: 90; Total number of losses: 22; Total Number of normals: 376.
Somatic mutations of GGCX:
Generating mutation plots.
Highly correlated genes for GGCX:
Showing top 20/1488 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GGCX | PPP6R3 | 0.772832 | 3 | 0 | 3 |
| GGCX | FAM168A | 0.764104 | 3 | 0 | 3 |
| GGCX | SOD2 | 0.749117 | 3 | 0 | 3 |
| GGCX | ALG10 | 0.749116 | 3 | 0 | 3 |
| GGCX | SAFB2 | 0.749116 | 3 | 0 | 3 |
| GGCX | ZFHX3 | 0.738855 | 3 | 0 | 3 |
| GGCX | BBX | 0.738468 | 3 | 0 | 3 |
| GGCX | IMMP1L | 0.737014 | 3 | 0 | 3 |
| GGCX | PRDX3 | 0.734235 | 3 | 0 | 3 |
| GGCX | MSTO1 | 0.722765 | 5 | 0 | 4 |
| GGCX | SFR1 | 0.718994 | 4 | 0 | 4 |
| GGCX | XXYLT1 | 0.718651 | 5 | 0 | 5 |
| GGCX | CD47 | 0.718051 | 4 | 0 | 4 |
| GGCX | SLC25A29 | 0.717743 | 3 | 0 | 3 |
| GGCX | TMEM138 | 0.716474 | 6 | 0 | 6 |
| GGCX | AP3D1 | 0.715459 | 3 | 0 | 3 |
| GGCX | FAM32A | 0.712908 | 4 | 0 | 4 |
| GGCX | SLC38A10 | 0.709475 | 4 | 0 | 3 |
| GGCX | RNF26 | 0.704958 | 3 | 0 | 3 |
| GGCX | MIER2 | 0.70188 | 3 | 0 | 3 |
For details and further investigation, click here
