| Full name: peroxiredoxin 3 | Alias Symbol: MER5|AOP-1|SP-22 | ||
| Type: protein-coding gene | Cytoband: 10q26.11 | ||
| Entrez ID: 10935 | HGNC ID: HGNC:9354 | Ensembl Gene: ENSG00000165672 | OMIM ID: 604769 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PRDX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRDX3 | 10935 | 201619_at | 0.2068 | 0.6209 | |
| GSE20347 | PRDX3 | 10935 | 201619_at | 0.5356 | 0.0021 | |
| GSE23400 | PRDX3 | 10935 | 201619_at | 0.5081 | 0.0000 | |
| GSE26886 | PRDX3 | 10935 | 201619_at | -0.6604 | 0.0240 | |
| GSE29001 | PRDX3 | 10935 | 201619_at | 0.3396 | 0.3503 | |
| GSE38129 | PRDX3 | 10935 | 201619_at | 0.3962 | 0.0267 | |
| GSE45670 | PRDX3 | 10935 | 201619_at | -0.0104 | 0.9576 | |
| GSE53622 | PRDX3 | 10935 | 19028 | 0.1156 | 0.0991 | |
| GSE53624 | PRDX3 | 10935 | 19028 | 0.1875 | 0.1139 | |
| GSE63941 | PRDX3 | 10935 | 201619_at | 0.0604 | 0.8854 | |
| GSE77861 | PRDX3 | 10935 | 201619_at | -0.0190 | 0.9741 | |
| GSE97050 | PRDX3 | 10935 | A_23_P63751 | 0.2066 | 0.5701 | |
| SRP007169 | PRDX3 | 10935 | RNAseq | 0.7098 | 0.0369 | |
| SRP008496 | PRDX3 | 10935 | RNAseq | 0.7043 | 0.0031 | |
| SRP064894 | PRDX3 | 10935 | RNAseq | 0.0254 | 0.8551 | |
| SRP133303 | PRDX3 | 10935 | RNAseq | 0.3032 | 0.0081 | |
| SRP159526 | PRDX3 | 10935 | RNAseq | 0.0317 | 0.9359 | |
| SRP193095 | PRDX3 | 10935 | RNAseq | 0.0037 | 0.9780 | |
| SRP219564 | PRDX3 | 10935 | RNAseq | -0.0374 | 0.9317 | |
| TCGA | PRDX3 | 10935 | RNAseq | -0.0725 | 0.0912 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRDX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRDX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRDX3 | 10935 | 2 | 8 | 20 | |
| GSE20123 | PRDX3 | 10935 | 2 | 8 | 20 | |
| GSE43470 | PRDX3 | 10935 | 0 | 9 | 34 | |
| GSE46452 | PRDX3 | 10935 | 0 | 11 | 48 | |
| GSE47630 | PRDX3 | 10935 | 2 | 14 | 24 | |
| GSE54993 | PRDX3 | 10935 | 8 | 0 | 62 | |
| GSE54994 | PRDX3 | 10935 | 1 | 9 | 43 | |
| GSE60625 | PRDX3 | 10935 | 0 | 0 | 11 | |
| GSE74703 | PRDX3 | 10935 | 0 | 6 | 30 | |
| GSE74704 | PRDX3 | 10935 | 1 | 3 | 16 | |
| TCGA | PRDX3 | 10935 | 4 | 28 | 64 |
Total number of gains: 20; Total number of losses: 96; Total Number of normals: 372.
Somatic mutations of PRDX3:
Generating mutation plots.
Highly correlated genes for PRDX3:
Showing top 20/1167 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRDX3 | TMEM218 | 0.790907 | 3 | 0 | 3 |
| PRDX3 | ZNF644 | 0.770442 | 3 | 0 | 3 |
| PRDX3 | EMB | 0.770235 | 3 | 0 | 3 |
| PRDX3 | FYTTD1 | 0.745789 | 3 | 0 | 3 |
| PRDX3 | INTS10 | 0.740996 | 3 | 0 | 3 |
| PRDX3 | RWDD4 | 0.736075 | 3 | 0 | 3 |
| PRDX3 | TM4SF18 | 0.735491 | 4 | 0 | 3 |
| PRDX3 | ANAPC16 | 0.73519 | 3 | 0 | 3 |
| PRDX3 | USP37 | 0.735044 | 3 | 0 | 3 |
| PRDX3 | GGCX | 0.734235 | 3 | 0 | 3 |
| PRDX3 | TATDN1 | 0.720784 | 4 | 0 | 3 |
| PRDX3 | NFKB1 | 0.717976 | 6 | 0 | 5 |
| PRDX3 | MB21D2 | 0.715856 | 3 | 0 | 3 |
| PRDX3 | PSME1 | 0.713645 | 4 | 0 | 3 |
| PRDX3 | LETMD1 | 0.712833 | 4 | 0 | 3 |
| PRDX3 | ZNHIT6 | 0.710488 | 3 | 0 | 3 |
| PRDX3 | RCN2 | 0.707979 | 8 | 0 | 8 |
| PRDX3 | C5orf51 | 0.707462 | 3 | 0 | 3 |
| PRDX3 | C12orf66 | 0.707322 | 3 | 0 | 3 |
| PRDX3 | ATG4C | 0.706838 | 4 | 0 | 3 |
For details and further investigation, click here
