| Full name: superoxide dismutase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q25.3 | ||
| Entrez ID: 6648 | HGNC ID: HGNC:11180 | Ensembl Gene: ENSG00000112096 | OMIM ID: 147460 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SOD2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway | |
| hsa04211 | Longevity regulating pathway - mammal | |
| hsa04213 | Longevity regulating pathway - multiple species |
Expression of SOD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOD2 | 6648 | 1566342_at | 0.2571 | 0.7739 | |
| GSE26886 | SOD2 | 6648 | 1566342_at | 0.5301 | 0.2283 | |
| GSE45670 | SOD2 | 6648 | 1566342_at | 0.7015 | 0.0006 | |
| GSE53622 | SOD2 | 6648 | 141103 | 0.2751 | 0.0094 | |
| GSE53624 | SOD2 | 6648 | 86838 | 0.5137 | 0.0000 | |
| GSE63941 | SOD2 | 6648 | 1566342_at | 0.0630 | 0.9475 | |
| GSE77861 | SOD2 | 6648 | 1566342_at | 0.1365 | 0.6553 | |
| GSE97050 | SOD2 | 6648 | A_23_P134176 | 1.2337 | 0.0772 | |
| SRP007169 | SOD2 | 6648 | RNAseq | -0.2526 | 0.5374 | |
| SRP008496 | SOD2 | 6648 | RNAseq | -0.4812 | 0.1361 | |
| SRP064894 | SOD2 | 6648 | RNAseq | 1.1118 | 0.0005 | |
| SRP133303 | SOD2 | 6648 | RNAseq | 1.1428 | 0.0003 | |
| SRP159526 | SOD2 | 6648 | RNAseq | 0.5417 | 0.2615 | |
| SRP193095 | SOD2 | 6648 | RNAseq | 1.1787 | 0.0000 | |
| SRP219564 | SOD2 | 6648 | RNAseq | 1.1101 | 0.0168 | |
| TCGA | SOD2 | 6648 | RNAseq | 0.1676 | 0.0126 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by SOD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOD2 | 6648 | 1 | 5 | 24 | |
| GSE20123 | SOD2 | 6648 | 1 | 4 | 25 | |
| GSE43470 | SOD2 | 6648 | 4 | 0 | 39 | |
| GSE46452 | SOD2 | 6648 | 3 | 10 | 46 | |
| GSE47630 | SOD2 | 6648 | 9 | 4 | 27 | |
| GSE54993 | SOD2 | 6648 | 3 | 2 | 65 | |
| GSE54994 | SOD2 | 6648 | 8 | 8 | 37 | |
| GSE60625 | SOD2 | 6648 | 0 | 1 | 10 | |
| GSE74703 | SOD2 | 6648 | 4 | 0 | 32 | |
| GSE74704 | SOD2 | 6648 | 0 | 2 | 18 | |
| TCGA | SOD2 | 6648 | 13 | 22 | 61 |
Total number of gains: 46; Total number of losses: 58; Total Number of normals: 384.
Somatic mutations of SOD2:
Generating mutation plots.
Highly correlated genes for SOD2:
Showing top 20/155 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOD2 | GGCX | 0.749117 | 3 | 0 | 3 |
| SOD2 | ANAPC4 | 0.74255 | 3 | 0 | 3 |
| SOD2 | TM9SF1 | 0.730588 | 3 | 0 | 3 |
| SOD2 | OSBPL3 | 0.711845 | 3 | 0 | 3 |
| SOD2 | HSD17B7 | 0.705307 | 3 | 0 | 3 |
| SOD2 | ENTPD4 | 0.692642 | 3 | 0 | 3 |
| SOD2 | STAT2 | 0.682262 | 4 | 0 | 3 |
| SOD2 | ARF1 | 0.681558 | 3 | 0 | 3 |
| SOD2 | MZT2B | 0.679605 | 4 | 0 | 3 |
| SOD2 | LARP1 | 0.676211 | 3 | 0 | 3 |
| SOD2 | CCNK | 0.674572 | 4 | 0 | 3 |
| SOD2 | SLC35E1 | 0.67281 | 4 | 0 | 4 |
| SOD2 | BIRC2 | 0.672807 | 3 | 0 | 3 |
| SOD2 | CDC42SE1 | 0.670247 | 3 | 0 | 3 |
| SOD2 | C9orf64 | 0.664361 | 4 | 0 | 3 |
| SOD2 | IGSF6 | 0.66403 | 3 | 0 | 3 |
| SOD2 | CD47 | 0.66289 | 4 | 0 | 3 |
| SOD2 | PDZK1IP1 | 0.657745 | 4 | 0 | 4 |
| SOD2 | PPIL1 | 0.653806 | 3 | 0 | 3 |
| SOD2 | DCLRE1C | 0.652849 | 3 | 0 | 3 |
For details and further investigation, click here
