| Full name: BBX high mobility group box domain containing | Alias Symbol: MDS001|HSPC339|HBP2 | ||
| Type: protein-coding gene | Cytoband: 3q13.12 | ||
| Entrez ID: 56987 | HGNC ID: HGNC:14422 | Ensembl Gene: ENSG00000114439 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of BBX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BBX | 56987 | 223135_s_at | 0.4112 | 0.4025 | |
| GSE20347 | BBX | 56987 | 213016_at | 0.2438 | 0.1179 | |
| GSE23400 | BBX | 56987 | 213016_at | 0.4002 | 0.0010 | |
| GSE26886 | BBX | 56987 | 232008_s_at | 1.2564 | 0.0000 | |
| GSE29001 | BBX | 56987 | 213015_at | 0.5423 | 0.0348 | |
| GSE38129 | BBX | 56987 | 213015_at | 0.3390 | 0.0446 | |
| GSE45670 | BBX | 56987 | 226331_at | -0.1934 | 0.2459 | |
| GSE53622 | BBX | 56987 | 51267 | 0.2652 | 0.0003 | |
| GSE53624 | BBX | 56987 | 51267 | 0.3967 | 0.0000 | |
| GSE63941 | BBX | 56987 | 232008_s_at | 0.3401 | 0.3858 | |
| GSE77861 | BBX | 56987 | 213016_at | 0.2576 | 0.4068 | |
| GSE97050 | BBX | 56987 | A_33_P3369311 | -0.3199 | 0.3467 | |
| SRP007169 | BBX | 56987 | RNAseq | 1.0668 | 0.0171 | |
| SRP008496 | BBX | 56987 | RNAseq | 1.3605 | 0.0000 | |
| SRP064894 | BBX | 56987 | RNAseq | 0.2702 | 0.1158 | |
| SRP133303 | BBX | 56987 | RNAseq | 0.2975 | 0.1340 | |
| SRP159526 | BBX | 56987 | RNAseq | 0.3168 | 0.0819 | |
| SRP193095 | BBX | 56987 | RNAseq | 0.3072 | 0.0006 | |
| SRP219564 | BBX | 56987 | RNAseq | 0.1295 | 0.7091 | |
| TCGA | BBX | 56987 | RNAseq | -0.0324 | 0.5756 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by BBX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BBX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BBX | 56987 | 18 | 1 | 11 | |
| GSE20123 | BBX | 56987 | 17 | 1 | 12 | |
| GSE43470 | BBX | 56987 | 18 | 1 | 24 | |
| GSE46452 | BBX | 56987 | 12 | 6 | 41 | |
| GSE47630 | BBX | 56987 | 16 | 6 | 18 | |
| GSE54993 | BBX | 56987 | 2 | 5 | 63 | |
| GSE54994 | BBX | 56987 | 28 | 5 | 20 | |
| GSE60625 | BBX | 56987 | 0 | 6 | 5 | |
| GSE74703 | BBX | 56987 | 15 | 1 | 20 | |
| GSE74704 | BBX | 56987 | 14 | 1 | 5 | |
| TCGA | BBX | 56987 | 49 | 9 | 38 |
Total number of gains: 189; Total number of losses: 42; Total Number of normals: 257.
Somatic mutations of BBX:
Generating mutation plots.
Highly correlated genes for BBX:
Showing top 20/1091 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BBX | LRP3 | 0.831605 | 3 | 0 | 3 |
| BBX | HIGD2A | 0.768182 | 3 | 0 | 3 |
| BBX | ALKBH6 | 0.75803 | 3 | 0 | 3 |
| BBX | LRRC14 | 0.750698 | 3 | 0 | 3 |
| BBX | SLAIN1 | 0.74858 | 3 | 0 | 3 |
| BBX | ZNF805 | 0.747797 | 3 | 0 | 3 |
| BBX | TRIM47 | 0.745594 | 3 | 0 | 3 |
| BBX | EIF3G | 0.740459 | 5 | 0 | 5 |
| BBX | GGCX | 0.738468 | 3 | 0 | 3 |
| BBX | ZNF766 | 0.737529 | 3 | 0 | 3 |
| BBX | HNRNPUL1 | 0.736401 | 3 | 0 | 3 |
| BBX | CYB5D1 | 0.730944 | 3 | 0 | 3 |
| BBX | CRTC2 | 0.729053 | 3 | 0 | 3 |
| BBX | NCKIPSD | 0.728541 | 3 | 0 | 3 |
| BBX | TBCB | 0.723895 | 3 | 0 | 3 |
| BBX | XAB2 | 0.72045 | 3 | 0 | 3 |
| BBX | DTYMK | 0.720302 | 4 | 0 | 4 |
| BBX | SSBP4 | 0.720182 | 4 | 0 | 3 |
| BBX | COA5 | 0.718814 | 3 | 0 | 3 |
| BBX | TSEN34 | 0.717406 | 3 | 0 | 3 |
For details and further investigation, click here
