| Full name: protein phosphatase 6 regulatory subunit 3 | Alias Symbol: SAPLa|DKFZp781E2374|DKFZp781O2362|DKFZp781E17107|SAP190|SAPL|PP6R3|FLJ11058|FLJ43065|KIAA1558|MGC125711|MGC125712 | ||
| Type: protein-coding gene | Cytoband: 11q13 | ||
| Entrez ID: 55291 | HGNC ID: HGNC:1173 | Ensembl Gene: ENSG00000110075 | OMIM ID: 610879 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PPP6R3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP6R3 | 55291 | 222467_s_at | 0.1692 | 0.6986 | |
| GSE20347 | PPP6R3 | 55291 | 217928_s_at | 0.4237 | 0.0009 | |
| GSE23400 | PPP6R3 | 55291 | 217928_s_at | 0.0986 | 0.1394 | |
| GSE26886 | PPP6R3 | 55291 | 222467_s_at | 0.6715 | 0.0050 | |
| GSE29001 | PPP6R3 | 55291 | 217928_s_at | 0.0929 | 0.5901 | |
| GSE38129 | PPP6R3 | 55291 | 217928_s_at | 0.2372 | 0.0266 | |
| GSE45670 | PPP6R3 | 55291 | 222467_s_at | -0.0331 | 0.8629 | |
| GSE53622 | PPP6R3 | 55291 | 58947 | 0.0935 | 0.2504 | |
| GSE53624 | PPP6R3 | 55291 | 58947 | 0.1843 | 0.0052 | |
| GSE63941 | PPP6R3 | 55291 | 222467_s_at | 1.3214 | 0.0145 | |
| GSE77861 | PPP6R3 | 55291 | 222467_s_at | 0.2336 | 0.2904 | |
| GSE97050 | PPP6R3 | 55291 | A_33_P3445805 | 0.1954 | 0.6563 | |
| SRP007169 | PPP6R3 | 55291 | RNAseq | -0.2097 | 0.4709 | |
| SRP008496 | PPP6R3 | 55291 | RNAseq | -0.0225 | 0.8833 | |
| SRP064894 | PPP6R3 | 55291 | RNAseq | -0.3172 | 0.0179 | |
| SRP133303 | PPP6R3 | 55291 | RNAseq | 0.2841 | 0.0806 | |
| SRP159526 | PPP6R3 | 55291 | RNAseq | 1.5244 | 0.0264 | |
| SRP193095 | PPP6R3 | 55291 | RNAseq | 0.1478 | 0.3103 | |
| SRP219564 | PPP6R3 | 55291 | RNAseq | -0.3469 | 0.0923 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PPP6R3 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of PPP6R3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP6R3 | 55291 | 11 | 3 | 16 | |
| GSE20123 | PPP6R3 | 55291 | 11 | 3 | 16 | |
| GSE43470 | PPP6R3 | 55291 | 7 | 3 | 33 | |
| GSE46452 | PPP6R3 | 55291 | 22 | 2 | 35 | |
| GSE47630 | PPP6R3 | 55291 | 13 | 3 | 24 | |
| GSE54993 | PPP6R3 | 55291 | 1 | 9 | 60 | |
| GSE54994 | PPP6R3 | 55291 | 18 | 4 | 31 | |
| GSE60625 | PPP6R3 | 55291 | 0 | 3 | 8 | |
| GSE74703 | PPP6R3 | 55291 | 6 | 2 | 28 | |
| GSE74704 | PPP6R3 | 55291 | 8 | 1 | 11 | |
| TCGA | PPP6R3 | 55291 | 40 | 8 | 48 |
Total number of gains: 137; Total number of losses: 41; Total Number of normals: 310.
Somatic mutations of PPP6R3:
Generating mutation plots.
Highly correlated genes for PPP6R3:
Showing top 20/558 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP6R3 | ANKRD50 | 0.833494 | 3 | 0 | 3 |
| PPP6R3 | CYP27C1 | 0.808239 | 3 | 0 | 3 |
| PPP6R3 | STK17A | 0.796487 | 3 | 0 | 3 |
| PPP6R3 | PON2 | 0.790044 | 3 | 0 | 3 |
| PPP6R3 | PXMP2 | 0.774155 | 3 | 0 | 3 |
| PPP6R3 | GGCX | 0.772832 | 3 | 0 | 3 |
| PPP6R3 | MB21D2 | 0.772004 | 3 | 0 | 3 |
| PPP6R3 | MRPL19 | 0.771386 | 3 | 0 | 3 |
| PPP6R3 | SLC4A1AP | 0.766172 | 3 | 0 | 3 |
| PPP6R3 | CARD10 | 0.759119 | 3 | 0 | 3 |
| PPP6R3 | FAF2 | 0.75694 | 4 | 0 | 4 |
| PPP6R3 | ARL5B | 0.755357 | 3 | 0 | 3 |
| PPP6R3 | HERPUD2 | 0.754764 | 3 | 0 | 3 |
| PPP6R3 | ADAM10 | 0.745006 | 4 | 0 | 4 |
| PPP6R3 | CTDSPL2 | 0.740826 | 4 | 0 | 4 |
| PPP6R3 | SERPINF2 | 0.740291 | 3 | 0 | 3 |
| PPP6R3 | UBA6 | 0.739819 | 4 | 0 | 4 |
| PPP6R3 | SPIRE1 | 0.736325 | 3 | 0 | 3 |
| PPP6R3 | KANSL2 | 0.73409 | 3 | 0 | 3 |
| PPP6R3 | MASTL | 0.732475 | 4 | 0 | 3 |
For details and further investigation, click here
