ZFHX3

 

Full name: zinc finger homeobox 3 Alias Symbol: ZNF927|FLJ26184
Type: protein-coding gene Cytoband: 16q22.2-q22.3
Entrez ID: 463 HGNC ID: HGNC:777 Ensembl Gene: ENSG00000140836 OMIM ID: 104155
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ZFHX3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZFHX3 463 226137_at 0.0413 0.9448
GSE20347 ZFHX3 463 208033_s_at 0.3456 0.0504
GSE23400 ZFHX3 463 208033_s_at 0.0640 0.3810
GSE26886 ZFHX3 463 226137_at 1.6058 0.0000
GSE29001 ZFHX3 463 208033_s_at 0.0163 0.9018
GSE38129 ZFHX3 463 208033_s_at 0.1718 0.2478
GSE45670 ZFHX3 463 226137_at -0.2571 0.3406
GSE53622 ZFHX3 463 19210 -0.1322 0.1484
GSE53624 ZFHX3 463 19210 0.2099 0.0026
GSE63941 ZFHX3 463 226137_at -1.3227 0.1199
GSE77861 ZFHX3 463 226137_at 0.8573 0.0003
GSE97050 ZFHX3 463 A_33_P3231542 -0.3483 0.3200
SRP007169 ZFHX3 463 RNAseq 2.0978 0.0000
SRP008496 ZFHX3 463 RNAseq 1.6674 0.0000
SRP064894 ZFHX3 463 RNAseq 0.4972 0.0338
SRP133303 ZFHX3 463 RNAseq 0.3816 0.0511
SRP159526 ZFHX3 463 RNAseq 0.7975 0.0001
SRP193095 ZFHX3 463 RNAseq 0.7144 0.0000
SRP219564 ZFHX3 463 RNAseq 0.2163 0.6251
TCGA ZFHX3 463 RNAseq -0.1299 0.0372

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by ZFHX3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZFHX3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZFHX3 463 4 0 26
GSE20123 ZFHX3 463 4 0 26
GSE43470 ZFHX3 463 2 8 33
GSE46452 ZFHX3 463 38 2 19
GSE47630 ZFHX3 463 11 8 21
GSE54993 ZFHX3 463 2 4 64
GSE54994 ZFHX3 463 8 10 35
GSE60625 ZFHX3 463 4 0 7
GSE74703 ZFHX3 463 2 5 29
GSE74704 ZFHX3 463 2 0 18
TCGA ZFHX3 463 24 20 52

Total number of gains: 101; Total number of losses: 57; Total Number of normals: 330.  

 

Somatic mutations of ZFHX3:

 

Generating mutation plots.

 

Highly correlated genes for ZFHX3:

 

Showing top 20/765 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZFHX3NFIL30.817932303
ZFHX3LRP120.816376303
ZFHX3C17orf750.812848303
ZFHX3SSRP10.812618303
ZFHX3RNF2170.807522303
ZFHX3STARD3NL0.797647303
ZFHX3IRF2BPL0.794681404
ZFHX3SNRPG0.789455303
ZFHX3FAM169A0.787216303
ZFHX3ZSCAN210.78218404
ZFHX3FANCL0.776575303
ZFHX3LPCAT10.772428303
ZFHX3ZBED10.766028303
ZFHX3NTPCR0.764647303
ZFHX3RRP150.756826303
ZFHX3PSMB10.751739303
ZFHX3AKAP80.751128303
ZFHX3KLHL130.745167504
ZFHX3RPA30.743117303
ZFHX3NACC10.742836303

For details and further investigation, click here