| Full name: gamma-glutamyltransferase 1 | Alias Symbol: D22S672|D22S732|CD224 | ||
| Type: protein-coding gene | Cytoband: 22q11.23 | ||
| Entrez ID: 2678 | HGNC ID: HGNC:4250 | Ensembl Gene: ENSG00000100031 | OMIM ID: 612346 |
| Drug and gene relationship at DGIdb | |||
Expression of GGT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GGT1 | 2678 | 233837_at | 0.0656 | 0.7793 | |
| GSE26886 | GGT1 | 2678 | 233837_at | -0.0354 | 0.7721 | |
| GSE45670 | GGT1 | 2678 | 233837_at | 0.0965 | 0.2891 | |
| GSE53622 | GGT1 | 2678 | 79325 | 0.3555 | 0.0012 | |
| GSE53624 | GGT1 | 2678 | 79325 | 0.2450 | 0.0056 | |
| GSE63941 | GGT1 | 2678 | 233837_at | 0.2391 | 0.0729 | |
| GSE77861 | GGT1 | 2678 | 233837_at | -0.1188 | 0.1978 | |
| GSE97050 | GGT1 | 2678 | A_24_P178175 | 0.3731 | 0.2966 | |
| SRP007169 | GGT1 | 2678 | RNAseq | 0.8163 | 0.2682 | |
| SRP064894 | GGT1 | 2678 | RNAseq | 0.8834 | 0.0175 | |
| SRP133303 | GGT1 | 2678 | RNAseq | 0.5491 | 0.1524 | |
| SRP159526 | GGT1 | 2678 | RNAseq | 0.1886 | 0.6643 | |
| SRP193095 | GGT1 | 2678 | RNAseq | 0.4316 | 0.1426 | |
| SRP219564 | GGT1 | 2678 | RNAseq | 0.2559 | 0.6238 | |
| TCGA | GGT1 | 2678 | RNAseq | -0.6050 | 0.0046 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GGT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GGT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GGT1 | 2678 | 5 | 7 | 18 | |
| GSE20123 | GGT1 | 2678 | 5 | 6 | 19 | |
| GSE43470 | GGT1 | 2678 | 3 | 6 | 34 | |
| GSE46452 | GGT1 | 2678 | 32 | 1 | 26 | |
| GSE47630 | GGT1 | 2678 | 8 | 5 | 27 | |
| GSE54993 | GGT1 | 2678 | 3 | 6 | 61 | |
| GSE54994 | GGT1 | 2678 | 11 | 7 | 35 | |
| GSE60625 | GGT1 | 2678 | 5 | 0 | 6 | |
| GSE74703 | GGT1 | 2678 | 3 | 5 | 28 | |
| GSE74704 | GGT1 | 2678 | 2 | 3 | 15 | |
| TCGA | GGT1 | 2678 | 26 | 15 | 55 |
Total number of gains: 103; Total number of losses: 61; Total Number of normals: 324.
Somatic mutations of GGT1:
Generating mutation plots.
Highly correlated genes for GGT1:
Showing top 20/110 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GGT1 | SLC4A1 | 0.761394 | 3 | 0 | 3 |
| GGT1 | CLDN9 | 0.742716 | 3 | 0 | 3 |
| GGT1 | CD300LF | 0.726859 | 3 | 0 | 3 |
| GGT1 | BSND | 0.716865 | 3 | 0 | 3 |
| GGT1 | ALPP | 0.708507 | 3 | 0 | 3 |
| GGT1 | CCDC33 | 0.706366 | 3 | 0 | 3 |
| GGT1 | IQCF3 | 0.698834 | 3 | 0 | 3 |
| GGT1 | TM6SF2 | 0.698284 | 4 | 0 | 4 |
| GGT1 | AVPR1B | 0.696348 | 3 | 0 | 3 |
| GGT1 | GFRA4 | 0.69112 | 3 | 0 | 3 |
| GGT1 | MEPE | 0.682175 | 3 | 0 | 3 |
| GGT1 | CDH22 | 0.671481 | 3 | 0 | 3 |
| GGT1 | PLA2G2F | 0.668471 | 3 | 0 | 3 |
| GGT1 | SLC39A5 | 0.665524 | 4 | 0 | 4 |
| GGT1 | OR10H1 | 0.663451 | 5 | 0 | 4 |
| GGT1 | IL23A | 0.658789 | 3 | 0 | 3 |
| GGT1 | KRTAP13-1 | 0.655174 | 4 | 0 | 3 |
| GGT1 | ZFHX2 | 0.654799 | 3 | 0 | 3 |
| GGT1 | TEKT2 | 0.644622 | 3 | 0 | 3 |
| GGT1 | C2orf81 | 0.641802 | 4 | 0 | 3 |
For details and further investigation, click here
