| Full name: arginine vasopressin receptor 1B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 553 | HGNC ID: HGNC:896 | Ensembl Gene: ENSG00000198049 | OMIM ID: 600264 |
| Drug and gene relationship at DGIdb | |||
AVPR1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04270 | Vascular smooth muscle contraction |
Expression of AVPR1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AVPR1B | 553 | 208260_at | -0.0977 | 0.7302 | |
| GSE20347 | AVPR1B | 553 | 208260_at | -0.2157 | 0.0546 | |
| GSE23400 | AVPR1B | 553 | 208260_at | -0.1033 | 0.0113 | |
| GSE26886 | AVPR1B | 553 | 208260_at | -0.4184 | 0.0231 | |
| GSE29001 | AVPR1B | 553 | 208260_at | -0.2397 | 0.1151 | |
| GSE38129 | AVPR1B | 553 | 208260_at | -0.2913 | 0.0015 | |
| GSE45670 | AVPR1B | 553 | 208260_at | 0.1312 | 0.2123 | |
| GSE53622 | AVPR1B | 553 | 31133 | 0.0648 | 0.2574 | |
| GSE53624 | AVPR1B | 553 | 31133 | 0.0261 | 0.6622 | |
| GSE63941 | AVPR1B | 553 | 208260_at | 0.1593 | 0.2387 | |
| GSE77861 | AVPR1B | 553 | 208260_at | -0.2470 | 0.1067 | |
| GSE97050 | AVPR1B | 553 | A_23_P72340 | -0.1875 | 0.4581 | |
| TCGA | AVPR1B | 553 | RNAseq | -5.0680 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AVPR1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AVPR1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AVPR1B | 553 | 11 | 0 | 19 | |
| GSE20123 | AVPR1B | 553 | 11 | 0 | 19 | |
| GSE43470 | AVPR1B | 553 | 7 | 0 | 36 | |
| GSE46452 | AVPR1B | 553 | 3 | 1 | 55 | |
| GSE47630 | AVPR1B | 553 | 14 | 0 | 26 | |
| GSE54993 | AVPR1B | 553 | 0 | 6 | 64 | |
| GSE54994 | AVPR1B | 553 | 14 | 0 | 39 | |
| GSE60625 | AVPR1B | 553 | 0 | 0 | 11 | |
| GSE74703 | AVPR1B | 553 | 7 | 0 | 29 | |
| GSE74704 | AVPR1B | 553 | 5 | 0 | 15 | |
| TCGA | AVPR1B | 553 | 43 | 5 | 48 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of AVPR1B:
Generating mutation plots.
Highly correlated genes for AVPR1B:
Showing top 20/898 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AVPR1B | ANKRD33B | 0.79357 | 3 | 0 | 3 |
| AVPR1B | PPM1N | 0.744505 | 3 | 0 | 3 |
| AVPR1B | OR2T1 | 0.737693 | 3 | 0 | 3 |
| AVPR1B | VIPR2 | 0.705739 | 6 | 0 | 6 |
| AVPR1B | ERN1 | 0.705633 | 5 | 0 | 5 |
| AVPR1B | RPS6KA2-AS1 | 0.701874 | 3 | 0 | 3 |
| AVPR1B | CTSE | 0.699649 | 4 | 0 | 3 |
| AVPR1B | KCNT1 | 0.699026 | 4 | 0 | 3 |
| AVPR1B | SV2B | 0.697724 | 3 | 0 | 3 |
| AVPR1B | IGSF9B | 0.69696 | 3 | 0 | 3 |
| AVPR1B | GGT1 | 0.696348 | 3 | 0 | 3 |
| AVPR1B | OTOG | 0.695469 | 3 | 0 | 3 |
| AVPR1B | CELA3B | 0.69123 | 5 | 0 | 5 |
| AVPR1B | SV2C | 0.684803 | 5 | 0 | 4 |
| AVPR1B | RNF157 | 0.679618 | 4 | 0 | 3 |
| AVPR1B | HAAO | 0.678754 | 8 | 0 | 7 |
| AVPR1B | PGC | 0.676874 | 5 | 0 | 4 |
| AVPR1B | KSR1 | 0.672513 | 4 | 0 | 3 |
| AVPR1B | A1CF | 0.670745 | 10 | 0 | 8 |
| AVPR1B | KRTAP3-1 | 0.670481 | 3 | 0 | 3 |
For details and further investigation, click here
