| Full name: interleukin 23 subunit alpha | Alias Symbol: SGRF|IL23P19|IL-23|IL-23A|P19 | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 51561 | HGNC ID: HGNC:15488 | Ensembl Gene: ENSG00000110944 | OMIM ID: 605580 |
| Drug and gene relationship at DGIdb | |||
IL23A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05152 | Tuberculosis | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL23A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL23A | 51561 | 220054_at | -0.7383 | 0.4041 | |
| GSE20347 | IL23A | 51561 | 220054_at | -0.1381 | 0.3597 | |
| GSE23400 | IL23A | 51561 | 220054_at | -0.3059 | 0.0000 | |
| GSE26886 | IL23A | 51561 | 220054_at | -0.6941 | 0.1089 | |
| GSE29001 | IL23A | 51561 | 220054_at | -0.3718 | 0.1148 | |
| GSE38129 | IL23A | 51561 | 220054_at | -0.0361 | 0.8311 | |
| GSE45670 | IL23A | 51561 | 220054_at | 0.5413 | 0.0905 | |
| GSE53622 | IL23A | 51561 | 21114 | 0.1843 | 0.3035 | |
| GSE53624 | IL23A | 51561 | 21114 | -0.6185 | 0.0008 | |
| GSE63941 | IL23A | 51561 | 220054_at | 0.6612 | 0.2435 | |
| GSE77861 | IL23A | 51561 | 220054_at | -0.5174 | 0.2415 | |
| GSE97050 | IL23A | 51561 | A_23_P76078 | 0.1484 | 0.5228 | |
| SRP133303 | IL23A | 51561 | RNAseq | -0.1492 | 0.7578 | |
| SRP159526 | IL23A | 51561 | RNAseq | -1.1290 | 0.2144 | |
| SRP219564 | IL23A | 51561 | RNAseq | 0.8865 | 0.2378 | |
| TCGA | IL23A | 51561 | RNAseq | 1.7598 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by IL23A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL23A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL23A | 51561 | 7 | 2 | 21 | |
| GSE20123 | IL23A | 51561 | 7 | 1 | 22 | |
| GSE43470 | IL23A | 51561 | 4 | 0 | 39 | |
| GSE46452 | IL23A | 51561 | 8 | 1 | 50 | |
| GSE47630 | IL23A | 51561 | 10 | 2 | 28 | |
| GSE54993 | IL23A | 51561 | 0 | 5 | 65 | |
| GSE54994 | IL23A | 51561 | 4 | 1 | 48 | |
| GSE60625 | IL23A | 51561 | 0 | 0 | 11 | |
| GSE74703 | IL23A | 51561 | 4 | 0 | 32 | |
| GSE74704 | IL23A | 51561 | 4 | 1 | 15 | |
| TCGA | IL23A | 51561 | 14 | 10 | 72 |
Total number of gains: 62; Total number of losses: 23; Total Number of normals: 403.
Somatic mutations of IL23A:
Generating mutation plots.
Highly correlated genes for IL23A:
Showing top 20/98 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL23A | SLC25A48 | 0.763418 | 3 | 0 | 3 |
| IL23A | CEP135 | 0.733379 | 3 | 0 | 3 |
| IL23A | MYLK2 | 0.728151 | 3 | 0 | 3 |
| IL23A | CCR6 | 0.726157 | 3 | 0 | 3 |
| IL23A | RNF32 | 0.716713 | 3 | 0 | 3 |
| IL23A | TDRD1 | 0.693874 | 3 | 0 | 3 |
| IL23A | BPIFB4 | 0.692092 | 3 | 0 | 3 |
| IL23A | HCRT | 0.685022 | 4 | 0 | 3 |
| IL23A | ZNRF2 | 0.682315 | 3 | 0 | 3 |
| IL23A | PRRG3 | 0.676503 | 3 | 0 | 3 |
| IL23A | FGF22 | 0.675898 | 4 | 0 | 3 |
| IL23A | PLEKHN1 | 0.671622 | 3 | 0 | 3 |
| IL23A | GP9 | 0.664224 | 3 | 0 | 3 |
| IL23A | PHF7 | 0.663284 | 4 | 0 | 3 |
| IL23A | ALX3 | 0.660518 | 3 | 0 | 3 |
| IL23A | RGL4 | 0.659929 | 3 | 0 | 3 |
| IL23A | GGT1 | 0.658789 | 3 | 0 | 3 |
| IL23A | KRT33A | 0.656248 | 3 | 0 | 3 |
| IL23A | RGR | 0.649709 | 4 | 0 | 3 |
| IL23A | DNASE1 | 0.648056 | 5 | 0 | 3 |
For details and further investigation, click here
