| Full name: serine peptidase inhibitor, Kunitz type 3 | Alias Symbol: HKIB9 | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 10816 | HGNC ID: HGNC:11248 | Ensembl Gene: ENSG00000101446 | OMIM ID: 613941 |
| Drug and gene relationship at DGIdb | |||
Expression of SPINT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPINT3 | 10816 | 215503_at | -0.0451 | 0.8269 | |
| GSE20347 | SPINT3 | 10816 | 215503_at | -0.0218 | 0.7740 | |
| GSE23400 | SPINT3 | 10816 | 215503_at | -0.1424 | 0.0008 | |
| GSE26886 | SPINT3 | 10816 | 215503_at | 0.0653 | 0.6378 | |
| GSE29001 | SPINT3 | 10816 | 215503_at | -0.3235 | 0.0442 | |
| GSE38129 | SPINT3 | 10816 | 215503_at | -0.0574 | 0.3561 | |
| GSE45670 | SPINT3 | 10816 | 215503_at | 0.0600 | 0.4574 | |
| GSE53622 | SPINT3 | 10816 | 13010 | 0.2780 | 0.1385 | |
| GSE53624 | SPINT3 | 10816 | 13010 | 0.1284 | 0.2083 | |
| GSE63941 | SPINT3 | 10816 | 215503_at | 0.0478 | 0.7666 | |
| GSE77861 | SPINT3 | 10816 | 215503_at | -0.0909 | 0.2779 | |
| GSE97050 | SPINT3 | 10816 | A_33_P3239620 | -0.0562 | 0.8074 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPINT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPINT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPINT3 | 10816 | 14 | 1 | 15 | |
| GSE20123 | SPINT3 | 10816 | 14 | 1 | 15 | |
| GSE43470 | SPINT3 | 10816 | 12 | 1 | 30 | |
| GSE46452 | SPINT3 | 10816 | 29 | 0 | 30 | |
| GSE47630 | SPINT3 | 10816 | 24 | 1 | 15 | |
| GSE54993 | SPINT3 | 10816 | 0 | 17 | 53 | |
| GSE54994 | SPINT3 | 10816 | 25 | 0 | 28 | |
| GSE60625 | SPINT3 | 10816 | 0 | 0 | 11 | |
| GSE74703 | SPINT3 | 10816 | 10 | 1 | 25 | |
| GSE74704 | SPINT3 | 10816 | 10 | 0 | 10 | |
| TCGA | SPINT3 | 10816 | 45 | 3 | 48 |
Total number of gains: 183; Total number of losses: 25; Total Number of normals: 280.
Somatic mutations of SPINT3:
Generating mutation plots.
Highly correlated genes for SPINT3:
Showing top 20/982 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPINT3 | TRAPPC9 | 0.802512 | 3 | 0 | 3 |
| SPINT3 | CCDC157 | 0.798839 | 3 | 0 | 3 |
| SPINT3 | C10orf90 | 0.792751 | 3 | 0 | 3 |
| SPINT3 | ENHO | 0.760854 | 4 | 0 | 4 |
| SPINT3 | IPO13 | 0.75231 | 3 | 0 | 3 |
| SPINT3 | SCGB1D2 | 0.746859 | 3 | 0 | 3 |
| SPINT3 | MACROD2-AS1 | 0.737272 | 3 | 0 | 3 |
| SPINT3 | RAB3IL1 | 0.733052 | 5 | 0 | 5 |
| SPINT3 | MOS | 0.727157 | 5 | 0 | 5 |
| SPINT3 | TBX10 | 0.726802 | 5 | 0 | 5 |
| SPINT3 | SIGLEC7 | 0.714159 | 5 | 0 | 5 |
| SPINT3 | SYT2 | 0.713993 | 7 | 0 | 6 |
| SPINT3 | ZNF852 | 0.712769 | 3 | 0 | 3 |
| SPINT3 | DEFB121 | 0.708027 | 4 | 0 | 3 |
| SPINT3 | UGT3A1 | 0.707549 | 3 | 0 | 3 |
| SPINT3 | PRAMEF5 | 0.702752 | 4 | 0 | 3 |
| SPINT3 | CHRNA2 | 0.700212 | 9 | 0 | 9 |
| SPINT3 | C11orf86 | 0.698759 | 3 | 0 | 3 |
| SPINT3 | IFNA4 | 0.698649 | 5 | 0 | 5 |
| SPINT3 | FSCN3 | 0.695366 | 8 | 0 | 7 |
For details and further investigation, click here
