PTK2B

 

Full name: protein tyrosine kinase 2 beta Alias Symbol: CAKB|PYK2|RAFTK|PTK|CADTK
Type: protein-coding gene Cytoband: 8p21.2
Entrez ID: 2185 HGNC ID: HGNC:9612 Ensembl Gene: ENSG00000120899 OMIM ID: 601212
Drug and gene relationship at DGIdb

 

PTK2B involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04670Leukocyte transendothelial migration
hsa04912GnRH signaling pathway
hsa05161Hepatitis B

 

Expression of PTK2B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PTK2B 2185 203110_at 0.5548 0.1694
GSE20347 PTK2B 2185 203110_at 0.2837 0.0153
GSE23400 PTK2B 2185 203110_at 0.2195 0.0019
GSE26886 PTK2B 2185 203110_at -0.2111 0.1833
GSE29001 PTK2B 2185 203110_at 0.1941 0.4911
GSE38129 PTK2B 2185 203110_at 0.1912 0.0849
GSE45670 PTK2B 2185 203110_at 0.2584 0.0148
GSE53622 PTK2B 2185 23266 0.4384 0.0005
GSE53624 PTK2B 2185 53032 0.3435 0.0223
GSE63941 PTK2B 2185 203110_at 0.3274 0.2924
GSE77861 PTK2B 2185 203110_at 0.0547 0.7408
GSE97050 PTK2B 2185 A_33_P3273000 0.3375 0.1752
SRP007169 PTK2B 2185 RNAseq 0.5667 0.2702
SRP008496 PTK2B 2185 RNAseq 0.3797 0.3765
SRP064894 PTK2B 2185 RNAseq 0.0702 0.6406
SRP133303 PTK2B 2185 RNAseq -0.0286 0.8863
SRP159526 PTK2B 2185 RNAseq -0.6150 0.0998
SRP193095 PTK2B 2185 RNAseq -0.1041 0.6050
SRP219564 PTK2B 2185 RNAseq 0.6234 0.1870
TCGA PTK2B 2185 RNAseq 0.0041 0.9601

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PTK2B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PTK2B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PTK2B 2185 4 11 15
GSE20123 PTK2B 2185 4 11 15
GSE43470 PTK2B 2185 4 7 32
GSE46452 PTK2B 2185 13 13 33
GSE47630 PTK2B 2185 10 8 22
GSE54993 PTK2B 2185 2 15 53
GSE54994 PTK2B 2185 10 15 28
GSE60625 PTK2B 2185 3 0 8
GSE74703 PTK2B 2185 4 6 26
GSE74704 PTK2B 2185 3 8 9
TCGA PTK2B 2185 16 43 37

Total number of gains: 73; Total number of losses: 137; Total Number of normals: 278.  

 

Somatic mutations of PTK2B:

 

Generating mutation plots.

 

Highly correlated genes for PTK2B:

 

Showing top 20/197 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PTK2BKIF21B0.804683404
PTK2BGNB30.760633303
PTK2BACAN0.729058404
PTK2BWAS0.711611303
PTK2BCPXM10.702823303
PTK2BTSPAN320.701923303
PTK2BCLDN90.700561303
PTK2BSEC14L40.699172303
PTK2BSHOX20.696666303
PTK2BTHAP30.693759303
PTK2BHRH30.692011303
PTK2BADRA1A0.686795303
PTK2BTAOK20.684989303
PTK2BSEZ6L20.675685303
PTK2BSLC6A30.675309403
PTK2BSPACA10.675081303
PTK2BSLC5A40.670399303
PTK2BNR1H40.669404303
PTK2BS1PR40.666411404
PTK2BZFPM10.665209303

For details and further investigation, click here