| Full name: D-2-hydroxyglutarate dehydrogenase | Alias Symbol: MGC25181|D2HGD|FLJ42195 | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 728294 | HGNC ID: HGNC:28358 | Ensembl Gene: ENSG00000180902 | OMIM ID: 609186 |
| Drug and gene relationship at DGIdb | |||
Expression of D2HGDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | D2HGDH | 728294 | 228738_at | -0.3323 | 0.2500 | |
| GSE26886 | D2HGDH | 728294 | 228738_at | -0.6561 | 0.0353 | |
| GSE45670 | D2HGDH | 728294 | 228738_at | -0.2213 | 0.1892 | |
| GSE53622 | D2HGDH | 728294 | 85279 | 0.3812 | 0.0000 | |
| GSE53624 | D2HGDH | 728294 | 85279 | 0.1884 | 0.0022 | |
| GSE63941 | D2HGDH | 728294 | 228738_at | -0.7344 | 0.0122 | |
| GSE77861 | D2HGDH | 728294 | 228738_at | -0.1370 | 0.4471 | |
| GSE97050 | D2HGDH | 728294 | A_33_P3355296 | 0.1946 | 0.3225 | |
| SRP064894 | D2HGDH | 728294 | RNAseq | -0.1176 | 0.7109 | |
| SRP133303 | D2HGDH | 728294 | RNAseq | -0.5788 | 0.0157 | |
| SRP159526 | D2HGDH | 728294 | RNAseq | -0.6187 | 0.1358 | |
| SRP193095 | D2HGDH | 728294 | RNAseq | -0.1304 | 0.5120 | |
| SRP219564 | D2HGDH | 728294 | RNAseq | -0.3800 | 0.4286 | |
| TCGA | D2HGDH | 728294 | RNAseq | -0.1998 | 0.0027 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by D2HGDH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of D2HGDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | D2HGDH | 728294 | 1 | 12 | 17 | |
| GSE20123 | D2HGDH | 728294 | 1 | 12 | 17 | |
| GSE43470 | D2HGDH | 728294 | 1 | 9 | 33 | |
| GSE46452 | D2HGDH | 728294 | 0 | 5 | 54 | |
| GSE47630 | D2HGDH | 728294 | 4 | 5 | 31 | |
| GSE54993 | D2HGDH | 728294 | 4 | 3 | 63 | |
| GSE54994 | D2HGDH | 728294 | 8 | 9 | 36 | |
| GSE60625 | D2HGDH | 728294 | 0 | 3 | 8 | |
| GSE74703 | D2HGDH | 728294 | 1 | 7 | 28 | |
| GSE74704 | D2HGDH | 728294 | 1 | 5 | 14 | |
| TCGA | D2HGDH | 728294 | 11 | 29 | 56 |
Total number of gains: 32; Total number of losses: 99; Total Number of normals: 357.
Somatic mutations of D2HGDH:
Generating mutation plots.
Highly correlated genes for D2HGDH:
Showing top 20/77 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| D2HGDH | IQCD | 0.760908 | 3 | 0 | 3 |
| D2HGDH | GNB3 | 0.7577 | 3 | 0 | 3 |
| D2HGDH | LRRC10 | 0.720085 | 3 | 0 | 3 |
| D2HGDH | POLM | 0.71625 | 3 | 0 | 3 |
| D2HGDH | FOXB1 | 0.715847 | 3 | 0 | 3 |
| D2HGDH | KCP | 0.703603 | 3 | 0 | 3 |
| D2HGDH | FANK1 | 0.701314 | 4 | 0 | 4 |
| D2HGDH | C2CD4D | 0.699753 | 3 | 0 | 3 |
| D2HGDH | ABCB9 | 0.69414 | 3 | 0 | 3 |
| D2HGDH | KCNK12 | 0.693489 | 4 | 0 | 3 |
| D2HGDH | MOB1B | 0.690294 | 4 | 0 | 3 |
| D2HGDH | FGF18 | 0.68755 | 3 | 0 | 3 |
| D2HGDH | ARFGEF1 | 0.685709 | 3 | 0 | 3 |
| D2HGDH | SPACA3 | 0.683863 | 4 | 0 | 4 |
| D2HGDH | ACAN | 0.682927 | 3 | 0 | 3 |
| D2HGDH | ZNF500 | 0.682835 | 4 | 0 | 4 |
| D2HGDH | FGF22 | 0.681598 | 4 | 0 | 3 |
| D2HGDH | TNNI3K | 0.665873 | 3 | 0 | 3 |
| D2HGDH | COG4 | 0.663434 | 3 | 0 | 3 |
| D2HGDH | PLA2G2C | 0.662098 | 3 | 0 | 3 |
For details and further investigation, click here
