GNG7

 

Full name: G protein subunit gamma 7 Alias Symbol: FLJ00058
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 2788 HGNC ID: HGNC:4410 Ensembl Gene: ENSG00000176533 OMIM ID: 604430
Drug and gene relationship at DGIdb

 

GNG7 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNG7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNG7 2788 228831_s_at -1.6044 0.1174
GSE20347 GNG7 2788 206896_s_at -0.0134 0.9096
GSE23400 GNG7 2788 206896_s_at -0.2306 0.0000
GSE26886 GNG7 2788 228831_s_at -0.0590 0.8152
GSE38129 GNG7 2788 206896_s_at -0.3825 0.0177
GSE45670 GNG7 2788 228831_s_at -2.5341 0.0000
GSE53622 GNG7 2788 11383 -1.8192 0.0000
GSE53624 GNG7 2788 11383 -1.2723 0.0000
GSE63941 GNG7 2788 206896_s_at 0.4536 0.3435
GSE77861 GNG7 2788 228831_s_at -0.0982 0.4415
GSE97050 GNG7 2788 A_23_P153897 -0.5005 0.1659
SRP064894 GNG7 2788 RNAseq -1.7649 0.0000
SRP133303 GNG7 2788 RNAseq -1.6592 0.0000
SRP159526 GNG7 2788 RNAseq -1.6156 0.0000
SRP193095 GNG7 2788 RNAseq -0.0493 0.8271
SRP219564 GNG7 2788 RNAseq -1.4191 0.0591
TCGA GNG7 2788 RNAseq -1.3899 0.0000

Upregulated datasets: 0; Downregulated datasets: 7.  

 

Survival by GNG7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNG7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNG7 2788 4 4 22
GSE20123 GNG7 2788 4 4 22
GSE43470 GNG7 2788 1 10 32
GSE46452 GNG7 2788 47 1 11
GSE47630 GNG7 2788 5 7 28
GSE54993 GNG7 2788 16 3 51
GSE54994 GNG7 2788 8 16 29
GSE60625 GNG7 2788 9 0 2
GSE74703 GNG7 2788 1 7 28
GSE74704 GNG7 2788 2 3 15
TCGA GNG7 2788 6 24 66

Total number of gains: 103; Total number of losses: 79; Total Number of normals: 306.  

 

Somatic mutations of GNG7:

 

Generating mutation plots.

 

Highly correlated genes for GNG7:

 

Showing top 20/1174 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNG7FIBIN0.824421303
GNG7RAB9B0.809527606
GNG7ZNF33B0.803857303
GNG7MAMDC20.798238505
GNG7ADAMTS9-AS20.786919404
GNG7ANGPTL10.785701605
GNG7FBXL30.785138303
GNG7ITPR10.783862606
GNG7MSRB30.782764505
GNG7C11orf960.778872303
GNG7C16orf860.778732303
GNG7WDR480.777977303
GNG7AOC30.775509706
GNG7CELF20.773838706
GNG7MED70.772183303
GNG7CYP21A20.771325303
GNG7CHRDL10.761968707
GNG7MACROD20.761052404
GNG7TAB10.760629303
GNG7IDH3G0.760225303

For details and further investigation, click here